5 Questions
Which cytosolic proteins recognize microbial RNA or DNA and induce the production of inflammatory and antiviral cytokines?
RLRs
What is the role of mitochondrial antiviral-signaling (MAVS) in the innate immune system?
It is required to initiate signaling events that activate transcription factors that induce the production of type I IFNs.
What distinguishes viral RNAs from mammalian RNAs, allowing RLRs to recognize them?
They have RNA with a 5′ triphosphate moiety not present in mammalian host cell cytosolic RNA.
Which pathway do most innate cytosolic DNA sensors engage to induce type 1 IFN production?
STING pathway
What is the role of autophagy in innate immunity?
To deliver cytosolic microbes to the lysosome, where they are killed by proteolytic enzymes.
Test your knowledge on the innate immune system's RIG-like receptors (RLRs) and their role in detecting viral RNA. Learn about the cytosolic proteins that activate the production of antiviral cytokines and type I IFNs. Challenge yourself with this quiz on the RLRs' recognition of viral RNAs and their contribution to the body's defense against infections.
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