Are You an Expert on RIG-Like Receptors?

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Questions and Answers

Which cytosolic proteins recognize microbial RNA or DNA and induce the production of inflammatory and antiviral cytokines?

  • RLRs (correct)
  • MAVS
  • STING
  • CDSs

What is the role of mitochondrial antiviral-signaling (MAVS) in the innate immune system?

  • It activates transcription factors that induce the production of type I IFNs.
  • It is required to initiate signaling events that activate transcription factors that induce the production of type I IFNs. (correct)
  • It stimulates autophagy, a mechanism by which cells degrade their own organelles in lysosomes.
  • It recognizes microbial DNA and responds by generating signals that lead to the production of inflammatory and antiviral cytokines.

What distinguishes viral RNAs from mammalian RNAs, allowing RLRs to recognize them?

  • They have dsRNA that is longer than dsRNA that may be formed transiently in normal cells.
  • They have RNA with a 5′ triphosphate moiety not present in mammalian host cell cytosolic RNA. (correct)
  • They have RNA with a 5’ 7methyl-guanosine “cap.”
  • They have RNA that is more stable than mammalian RNA.

Which pathway do most innate cytosolic DNA sensors engage to induce type 1 IFN production?

<p>STING pathway (A)</p> Signup and view all the answers

What is the role of autophagy in innate immunity?

<p>To deliver cytosolic microbes to the lysosome, where they are killed by proteolytic enzymes. (A)</p> Signup and view all the answers

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