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Questions and Answers
Which cytosolic proteins recognize microbial RNA or DNA and induce the production of inflammatory and antiviral cytokines?
Which cytosolic proteins recognize microbial RNA or DNA and induce the production of inflammatory and antiviral cytokines?
- RLRs (correct)
- MAVS
- STING
- CDSs
What is the role of mitochondrial antiviral-signaling (MAVS) in the innate immune system?
What is the role of mitochondrial antiviral-signaling (MAVS) in the innate immune system?
- It activates transcription factors that induce the production of type I IFNs.
- It is required to initiate signaling events that activate transcription factors that induce the production of type I IFNs. (correct)
- It stimulates autophagy, a mechanism by which cells degrade their own organelles in lysosomes.
- It recognizes microbial DNA and responds by generating signals that lead to the production of inflammatory and antiviral cytokines.
What distinguishes viral RNAs from mammalian RNAs, allowing RLRs to recognize them?
What distinguishes viral RNAs from mammalian RNAs, allowing RLRs to recognize them?
- They have dsRNA that is longer than dsRNA that may be formed transiently in normal cells.
- They have RNA with a 5′ triphosphate moiety not present in mammalian host cell cytosolic RNA. (correct)
- They have RNA with a 5’ 7methyl-guanosine “cap.”
- They have RNA that is more stable than mammalian RNA.
Which pathway do most innate cytosolic DNA sensors engage to induce type 1 IFN production?
Which pathway do most innate cytosolic DNA sensors engage to induce type 1 IFN production?
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What is the role of autophagy in innate immunity?
What is the role of autophagy in innate immunity?
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