Arbovirus Quiz
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Questions and Answers

Which family does Yellow Fever Virus belong to?

  • Retroviridae
  • Flaviviridae (correct)
  • Bunyaviridae
  • Togaviridae
  • What is the primary vector for transmission of Chikungunya virus?

  • Culex mosquito
  • Anopheles mosquito
  • Aedes aegypti mosquito (correct)
  • Tick
  • Which virus is associated with Rift Valley Fever?

  • Coronaviridae
  • Flaviviridae
  • Togaviridae
  • Bunyaviridae (correct)
  • What is the main method for diagnosis of Dengue virus infection?

    <p>PCR (Polymerase Chain Reaction)</p> Signup and view all the answers

    What is the timeframe for the gradual reabsorption of extravascular compartment fluid in the recovery phase of dengue?

    <p>48-72 hours</p> Signup and view all the answers

    What may happen if excessive IV fluids have been administered during dengue recovery?

    <p>Respiratory distress from massive pleural effusion and ascites</p> Signup and view all the answers

    What is a potential consequence of lack of IV fluids administered during dengue recovery?

    <p>Dengue shock syndrome</p> Signup and view all the answers

    What is almost always associated with profound shock and is in combination with thrombocytopenia, hypoxia, and acidosis in severe dengue cases?

    <p>Major bleeding</p> Signup and view all the answers

    When should severe dengue be considered in a patient?

    <p>If the patient is a resident of high-risk area and has 2-7 days fever plus evidence of plasma leakage, significant bleeding, or altered level of consciousness</p> Signup and view all the answers

    What are some unusual manifestations of dengue mentioned in the text?

    <p>Acute liver failure, encephalopathy, cardiomyopathy, encephalitis</p> Signup and view all the answers

    What is a potential outcome of excessive fluid therapy during dengue recovery?

    <p>Pulmonary edema or congestive heart failure</p> Signup and view all the answers

    What is the most common cause of death in dengue patients?

    <p>Profound shock, especially in cases with fluid overload</p> Signup and view all the answers

    What is the main approach for Chikungunya treatment?

    <p>Supportive treatment as no specific antiviral therapy exists</p> Signup and view all the answers

    How is Wolbachia utilized to control Ae. aegypti mosquito population?

    <p>Wolbachia-infected male mosquitoes render wild female mosquitoes' eggs unhatchable</p> Signup and view all the answers

    What is the incubation period for Chikungunya fever?

    <p>1-12 days</p> Signup and view all the answers

    What is the family of arboviruses including Chikungunya called?

    <p>Togaviridae</p> Signup and view all the answers

    Which virus causes Rift Valley Fever?

    <p>Bunyaviridae</p> Signup and view all the answers

    Where is Chikungunya primarily found?

    <p>Africa, India, and Southeast Asia</p> Signup and view all the answers

    What type of tests are used for lab findings of Chikungunya?

    <p>Virus isolation, serological tests, and RT-PCR</p> Signup and view all the answers

    How is Rift Valley Fever transmitted?

    <p>By mosquitoes and biting flies</p> Signup and view all the answers

    What is the approach for prevention and control of Chikungunya?

    <p>Surveillance, early outbreak identification, and vector control</p> Signup and view all the answers

    Which bacteria is utilized to control Ae. aegypti mosquito population?

    <p>Wolbachia</p> Signup and view all the answers

    What are the clinical features of Chikungunya fever?

    <p>Joint pain and various symptoms</p> Signup and view all the answers

    What is the common approach for treatment of Chikungunya fever?

    <p>Supportive treatment as no specific antiviral therapy exists</p> Signup and view all the answers

    What are the natural reservoirs of arboviruses?

    <p>Animals, birds, and reptiles</p> Signup and view all the answers

    How do arboviruses perpetuate in the environment?

    <p>Through transovarian transmission in arthropods</p> Signup and view all the answers

    What is the primary mode of transmission for arboviruses?

    <p>Through the saliva of arthropods during biting</p> Signup and view all the answers

    How do arboviruses maintain themselves in nature?

    <p>By cycling between a host and an arthropod vector</p> Signup and view all the answers

    Where does viral multiplication occur in the body?

    <p>Myeloid and lymphoid cells or vascular endothelium</p> Signup and view all the answers

    What are some common symptoms of arboviral diseases?

    <p>Diarrhea, vomiting, body aches, fever, and rashes</p> Signup and view all the answers

    Which of the following are arthropod vectors for arboviruses?

    <p>Mosquitoes, sandflies, and ticks</p> Signup and view all the answers

    What are used for diagnosing arbovirus infections?

    <p>Serology, direct detection tests, and culture</p> Signup and view all the answers

    Which of the following arboviral infections has a vaccine available?

    <p>Yellow fever</p> Signup and view all the answers

    What influences the constant distribution of arthropod vectors?

    <p>Socioeconomic, medical, and climatic factors</p> Signup and view all the answers

    What is important in addressing arboviral infections?

    <p>One Health and Eco-Health approaches</p> Signup and view all the answers

    What are the blood-sucking arthropods that can transmit arboviral diseases?

    <p>Mosquitoes, ticks, and sandflies</p> Signup and view all the answers

    What is the primary vector for dengue?

    <p>Aedes Aegypti mosquito</p> Signup and view all the answers

    What is the size range of the dengue virus?

    <p>40-60 nm</p> Signup and view all the answers

    How does transmission of the dengue virus to humans occur?

    <p>Through mosquito saliva</p> Signup and view all the answers

    What are the clinical manifestations of dengue?

    <p>High fever and severe headache</p> Signup and view all the answers

    What is characteristic of the febrile phase of dengue?

    <p>Sudden high-grade fever, myalgia, headache</p> Signup and view all the answers

    What does the critical phase of dengue involve?

    <p>Severe hemorrhage and organ impairment</p> Signup and view all the answers

    How can severe dengue be detected?

    <p>Blood tests or CBC</p> Signup and view all the answers

    What is crucial in increasing the survival rate of dengue patients?

    <p>Early clinical diagnosis and careful management</p> Signup and view all the answers

    Who does dengue virus infection affect?

    <p>Infants, young children, and adults</p> Signup and view all the answers

    What is the life cycle of the dengue virus?

    <p>Egg production, larval development, pupa emergence, mating of adult mosquitoes</p> Signup and view all the answers

    What is the characteristic of Aedes Aegypti's feeding behavior?

    <p>Daytime feeder and indoor biter</p> Signup and view all the answers

    Where does Aedes Aegypti lay its eggs?

    <p>Indoor artificial containers with water</p> Signup and view all the answers

    Which arthropod vector is associated with the Rift Valley Fever virus?

    <p>Aedes</p> Signup and view all the answers

    Which method is used for diagnosing Rift Valley Fever virus?

    <p>RT-PCR, ELISA, and culture from blood and tissues samples</p> Signup and view all the answers

    Where is Yellow Fever virus mainly found?

    <p>West Africa and South America</p> Signup and view all the answers

    What is the primary transmission vector for Japanese Encephalitis?

    <p>Culex mosquitoes</p> Signup and view all the answers

    What is the primary method for preventing Rift Valley Fever?

    <p>Avoiding contact with infected animals and protecting against mosquitoes</p> Signup and view all the answers

    Which virus causes a wide range of clinical symptoms, including hemorrhagic fever and encephalitis?

    <p>Flaviviridae</p> Signup and view all the answers

    What is the history of dengue's pandemic spread?

    <p>Beginning in Southeast Asia after World War II and currently present in Africa, the Americas, Asia, the Caribbean, and the Pacific</p> Signup and view all the answers

    What is the primary symptom of dengue infection with another serotype, especially serotype 2?

    <p>Dengue hemorrhagic fever causing hemorrhage or shock</p> Signup and view all the answers

    What is the primary method for diagnosing dengue?

    <p>Serology tests</p> Signup and view all the answers

    What was the significant event in 2020 related to dengue?

    <p>France and Italy reported autochthonous dengue cases</p> Signup and view all the answers

    What is the primary characteristic of most human infections of Japanese Encephalitis?

    <p>Subclinical</p> Signup and view all the answers

    What are the two major forms of Yellow Fever virus?

    <p>Urban and Jungle (sylvatic) yellow fever</p> Signup and view all the answers

    Which virus is a member of the genus Morbillivirus?

    <p>Measles virus</p> Signup and view all the answers

    What is the primary characteristic of rubella infection?

    <p>Congenital rubella syndrome</p> Signup and view all the answers

    Which virus primarily causes parotitis and orchitis in males?

    <p>Mumps virus</p> Signup and view all the answers

    What is the primary route of transmission for measles?

    <p>Respiratory transmission</p> Signup and view all the answers

    When does the secondary viremia occur after exposure to measles virus?

    <p>5 to 7 days after exposure</p> Signup and view all the answers

    What is the characteristic feature of Koplik's spots in measles?

    <p>They resemble grain of salt beneath the buccal mucous membrane</p> Signup and view all the answers

    What is the cause of the maculopapular rash in measles?

    <p>Interaction of immune T cells with virus-infected cells</p> Signup and view all the answers

    What is the most common cause of measles-related deaths?

    <p>Pneumonia</p> Signup and view all the answers

    What is the rare but life-threatening complication characterized by behavioral and intellectual deterioration and seizures years after acute measles infection?

    <p>Subacute sclerosing panencephalitis (SSPE)</p> Signup and view all the answers

    Which of the following is a characteristic of atypical/modified measles?

    <p>Shows mild signs and symptoms</p> Signup and view all the answers

    What is the primary method for preventing measles?

    <p>Vaccination</p> Signup and view all the answers

    What is the characteristic feature of the measles rash?

    <p>No scarring</p> Signup and view all the answers

    What is the primary symptom of measles infection during the prodromal period?

    <p>Fever</p> Signup and view all the answers

    What is the characteristic of the exanthem period in measles?

    <p>Rash is a sign of satisfactory immune response</p> Signup and view all the answers

    What is the mean incubation period for measles?

    <p>10 days</p> Signup and view all the answers

    Which of the following is a characteristic of the measles virus in the context of the described disease?

    <p>It can cause progressive mental deterioration and involuntary movements</p> Signup and view all the answers

    What is the primary method for diagnosing atypical measles?

    <p>Serology (ELISA)</p> Signup and view all the answers

    What is the distribution of measles worldwide?

    <p>Highly infectious and distributed worldwide</p> Signup and view all the answers

    What is the primary habitat of the measles virus?

    <p>Human</p> Signup and view all the answers

    What is the primary approach for preventing measles outbreaks?

    <p>Vaccination campaigns to achieve herd immunity</p> Signup and view all the answers

    What is the incubation period for measles?

    <p>1-2 weeks</p> Signup and view all the answers

    What is the primary mode of transmission for measles?

    <p>Respiratory droplets</p> Signup and view all the answers

    What is the characteristic of the humoral immune response to measles infection?

    <p>Production of IgM, IgA, and IgG antibodies</p> Signup and view all the answers

    What is the significance of atypical measles in the context of diagnosis?

    <p>It requires specific laboratory techniques like ELISA</p> Signup and view all the answers

    What is the primary characteristic of measles infection in individuals with defective cell-mediated immunity?

    <p>Lack of rash development</p> Signup and view all the answers

    What is the primary cause of immune suppression following measles infection?

    <p>Replication of virus within monocytes and other white blood cells</p> Signup and view all the answers

    What is the primary characteristic of measles outbreaks before widespread vaccination campaigns?

    <p>Endemic infections punctuating every two to three years</p> Signup and view all the answers

    What is the protective antibody percentage after the 1st dose of the measles-rubella vaccine?

    <p>95%</p> Signup and view all the answers

    Which trimester of pregnancy has the highest risk for structural abnormalities in congenital rubella syndrome?

    <p>1st trimester</p> Signup and view all the answers

    What is the main method for diagnosis of rubella?

    <p>Isolation from clinical specimens</p> Signup and view all the answers

    What is the primary treatment approach for congenital rubella syndrome?

    <p>Supportive care</p> Signup and view all the answers

    What is the recommended prophylaxis for rubella in certain cases?

    <p>Human immunoglobulin</p> Signup and view all the answers

    Which diagnostic marker can be specific to congenital rubella syndrome?

    <p>Specific IgM and IgG observation</p> Signup and view all the answers

    What is the primary method for preventing congenital rubella?

    <p>Active immunization</p> Signup and view all the answers

    In which trimester does measles affect 85% of infants in third world countries?

    <p>1st trimester</p> Signup and view all the answers

    Which trimester has the lowest risk of structural abnormalities in congenital rubella syndrome?

    <p>3rd trimester</p> Signup and view all the answers

    What is the primary method for laboratory diagnosis of rubella?

    <p>Isolation from clinical specimens</p> Signup and view all the answers

    What is the main approach for preventing rubella in certain groups?

    <p>Active immunization</p> Signup and view all the answers

    What is the most common manifestation of congenital rubella syndrome?

    <p>Deafness</p> Signup and view all the answers

    Which of the following is NOT a structural protein of the measles virus?

    <p>Neuraminidase (N)</p> Signup and view all the answers

    What is the incubation period of measles?

    <p>10 to 12 days</p> Signup and view all the answers

    Which cellular receptor does the measles virus attach to?

    <p>CD-46 receptor</p> Signup and view all the answers

    What is a characteristic sign of measles infection?

    <p>Koplik's spots</p> Signup and view all the answers

    What is the primary mode of transmission for the measles virus?

    <p>Respiratory secretions</p> Signup and view all the answers

    Which of the following is a consequence of measles virus infection?

    <p>Generalized immunosuppression</p> Signup and view all the answers

    What is a major cause of measles-related mortality among young children?

    <p>Bronchopneumonia</p> Signup and view all the answers

    How many serotypes of the measles virus are recognized?

    <p>1</p> Signup and view all the answers

    Which of the following animals can be affected by the measles virus?

    <p>Seals</p> Signup and view all the answers

    What is the characteristic cellular response to measles virus replication?

    <p>Syncytium formation</p> Signup and view all the answers

    What is essential for tracking outbreaks and identifying significant antigenic variations in measles virus strains?

    <p>Molecular surveillance</p> Signup and view all the answers

    Which of the following is a symptom of measles infection?

    <p>Conjunctivitis</p> Signup and view all the answers

    Which of the following is NOT true regarding Rubella?

    <p>Also known as measles</p> Signup and view all the answers

    During primary viremia, the virus spreads and replicates in the blood. In secondary viremia, infected persons begin to shed the virus from the nasopharynx 6-14 days after exposure for 3-8 days after rash onset.

    <p>Both statements are incorrect.</p> Signup and view all the answers

    The presence of this component differentiates mumps from measles virus.

    <p>Neuraminidase</p> Signup and view all the answers

    Which heart-related disease in congenital rubella syndrome is due to the abnormal development of the fetal heart during the first 8 weeks of pregnancy?

    <p>Pulmonary Atresia</p> Signup and view all the answers

    The following are complications associated with mumps EXCEPT:

    <p>Blindness</p> Signup and view all the answers

    Which of the following does not belong to the classical triad of Rubella in infected neonates?

    <p>Congenital defects</p> Signup and view all the answers

    Which of the following is NOT true regarding Mumps?

    <p>Active immunization for Mumps gives lifelong immunity to an individual.</p> Signup and view all the answers

    Which of the following is NOT true regarding Measles vaccine?

    <p>It is a type of inactivated vaccine.</p> Signup and view all the answers

    T/F Active immunization for Rubella gives lifelong immunity to an individual.

    <p>True</p> Signup and view all the answers

    Organogenesis period happens in what stage of pregnancy?

    <p>First 8 weeks of pregnancy</p> Signup and view all the answers

    This method of laboratory diagnosis can be used to detect viral mumps RNA and fosters a rapid confirmation for the diagnosis

    <p>PCR</p> Signup and view all the answers

    Which of the following is correct regarding measles?

    <p>It is caused by a negative ssRNA virus.</p> Signup and view all the answers

    Which of the following is a characteristic feature of the measles rash?

    <p>Maculopapular rash starting from the face and spreading downwards</p> Signup and view all the answers

    What is the primary method for preventing congenital rubella?

    <p>Vaccination of susceptible individuals</p> Signup and view all the answers

    What are the natural reservoirs of arboviruses?

    <p>Rodents and birds</p> Signup and view all the answers

    What is the primary cause of a persistent measles infection leading to a Progressive degenerative CNS disease?

    <p>Defective form of measles virus in the brain cell</p> Signup and view all the answers

    What is the significance of the presence of humoral antibodies in measles immunity?

    <p>Indicates immunity for a lifetime</p> Signup and view all the answers

    What is the primary method for diagnosing measles through laboratory diagnosis?

    <p>Serology (ELISA)</p> Signup and view all the answers

    What is the primary mode of transmission for measles?

    <p>Respiratory droplets</p> Signup and view all the answers

    What is the distribution of measles worldwide?

    <p>Worldwide</p> Signup and view all the answers

    What is the incubation period for measles?

    <p>2-3 weeks</p> Signup and view all the answers

    What is the primary method for preventing measles?

    <p>Vaccination</p> Signup and view all the answers

    What is the primary habitat of the measles virus?

    <p>Human</p> Signup and view all the answers

    What is the primary characteristic of atypical measles?

    <p>Lack of rash</p> Signup and view all the answers

    What is the primary method for diagnosing atypical measles in hospitals?

    <p>Serology (ELISA)</p> Signup and view all the answers

    What is the primary characteristic of measles infection in individuals with defective cell-mediated immunity?

    <p>Lack of rash</p> Signup and view all the answers

    What is the primary method for detecting severe dengue?

    <p>Detection of plasma leakage</p> Signup and view all the answers

    What is the primary cause of immune suppression following measles infection?

    <p>Cytokine storm</p> Signup and view all the answers

    What is the mean incubation period for measles?

    <p>14-21 days</p> Signup and view all the answers

    What is the characteristic feature of the measles rash?

    <p>Maculopapular rash</p> Signup and view all the answers

    Which trimester has the lowest risk of structural abnormalities in congenital rubella syndrome?

    <p>3rd trimester</p> Signup and view all the answers

    What is the primary method for diagnosing atypical measles?

    <p>PCR testing</p> Signup and view all the answers

    Which of the following is NOT true regarding Mumps?

    <p>It can cause deafness</p> Signup and view all the answers

    What is the primary method for preventing congenital rubella?

    <p>Routine immunization</p> Signup and view all the answers

    What is the characteristic of Aedes Aegypti's feeding behavior?

    <p>Diurnal feeding</p> Signup and view all the answers

    What is the primary symptom of measles infection during the prodromal period?

    <p>Fever</p> Signup and view all the answers

    What are some common symptoms of arboviral diseases?

    <p>Arthralgia, myalgia, rash</p> Signup and view all the answers

    What is the distribution of measles worldwide?

    <p>Endemic</p> Signup and view all the answers

    What is the primary vector for dengue?

    <p>Aedes Aegypti</p> Signup and view all the answers

    What is the primary site of initial measles virus replication?

    <p>Tracheal and bronchial epithelial cells</p> Signup and view all the answers

    When does the secondary viremia occur after exposure to measles virus?

    <p>4 to 6 days</p> Signup and view all the answers

    What is the characteristic appearance of Koplik's spots in measles?

    <p>Resembles grain of salt just beneath the mucosa</p> Signup and view all the answers

    What causes the maculopapular rash in measles?

    <p>Interaction of immune T cells with virus-infected cells in the small blood vessels</p> Signup and view all the answers

    What is the significance of the absence of rash in measles infection?

    <p>Indicates a severe form of the disease</p> Signup and view all the answers

    What is the most common cause of measles-related deaths?

    <p>Pneumonia</p> Signup and view all the answers

    In which condition does giant cell pneumonia occur as a complication of measles?

    <p>Immunodeficient children</p> Signup and view all the answers

    What is the rare complication characterized by progressive mental deterioration and seizures years after an acute measles infection?

    <p>SSPE (subacute sclerosing panencephalitis)</p> Signup and view all the answers

    What is the mean incubation period for measles?

    <p>10 days</p> Signup and view all the answers

    What is the most common complication of measles in partially immune persons?

    <p>Atypical rash</p> Signup and view all the answers

    What is the primary cause of most measles-related deaths in developing countries?

    <p>Malnutrition</p> Signup and view all the answers

    What is the primary characteristic of the exanthem period in measles?

    <p>Maculopapular rash</p> Signup and view all the answers

    Which of the following is NOT true regarding Mumps vaccine?

    <p>The vaccine primarily consists of the H protein</p> Signup and view all the answers

    Which of the following is NOT a complication associated with Mumps?

    <p>Blindness</p> Signup and view all the answers

    During primary viremia, the virus spreads and replicates in the blood. In secondary viremia, infected persons begin to shed the virus from the nasopharynx 6-14 days after exposure for 3-8 days after rash onset.

    <p>Both statements are incorrect.</p> Signup and view all the answers

    The presence of this component differentiates mumps from measles virus.

    <p>Neuraminidase</p> Signup and view all the answers

    Which heart-related disease in congenital rubella syndrome is due to the abnormal development of the fetal heart during the first 8 weeks of pregnancy?

    <p>Pulmonary Atresia</p> Signup and view all the answers

    Which of the following does not belong to the classical triad of Rubella in infected neonates?

    <p>Congenital defects</p> Signup and view all the answers

    Which of the following is NOT true regarding Rubella?

    <p>Also known as measles</p> Signup and view all the answers

    Which of the following is NOT true regarding Active immunization for Rubella?

    <p>It primarily consists of the L protein</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the measles virus in the context of the described disease?

    <p>Primarily consists of the L protein</p> Signup and view all the answers

    Which of the following is NOT true regarding Measles vaccine?

    <p>The vaccine primarily consists of the H protein</p> Signup and view all the answers

    Which of the following is NOT true regarding Rubella vaccine?

    <p>The vaccine primarily consists of the H protein</p> Signup and view all the answers

    What is the incubation period of measles?

    <p>10 to 12 days</p> Signup and view all the answers

    How many virion structural proteins does the measles virus encode?

    <p>6</p> Signup and view all the answers

    What is the primary cause of immune suppression following measles infection?

    <p>Decrease in delayed type hypersensitivity</p> Signup and view all the answers

    Which cellular receptor does the measles virus attach to?

    <p>CD-46</p> Signup and view all the answers

    What are the characteristic signs of measles infection?

    <p>All of the above</p> Signup and view all the answers

    What is the primary mode of transmission for the measles virus?

    <p>Respiratory secretions</p> Signup and view all the answers

    What is the primary vector for transmission of Chikungunya virus?

    <p>Aedes aegypti</p> Signup and view all the answers

    What is the primary habitat of the measles virus?

    <p>Humans</p> Signup and view all the answers

    What is the mean incubation period for measles?

    <p>14 days</p> Signup and view all the answers

    What is the primary method for preventing congenital rubella?

    <p>Vaccination</p> Signup and view all the answers

    What is the primary characteristic of measles infection in individuals with defective cell-mediated immunity?

    <p>Giant multinucleated cell formation</p> Signup and view all the answers

    What is the primary method for diagnosis of rubella?

    <p>Serological testing</p> Signup and view all the answers

    What is the primary site of initial measles virus replication?

    <p>Respiratory epithelium</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the rubella virus in the context of the described disease?

    <p>Causes gastroenteritis</p> Signup and view all the answers

    What is the primary mode of transmission for mumps?

    <p>Respiratory droplets</p> Signup and view all the answers

    What is the primary method for diagnosing congenital rubella syndrome?

    <p>Isolation from clinical specimens</p> Signup and view all the answers

    What is the primary characteristic of the measles-rubella vaccine?

    <p>It has no complications</p> Signup and view all the answers

    What is the primary mode of passive prophylaxis for rubella?

    <p>Human immunoglobulin</p> Signup and view all the answers

    What is the primary risk factor for structural abnormalities in congenital rubella syndrome?

    <p>Gestational age</p> Signup and view all the answers

    When was the measles-rubella vaccine first available for routine immunization?

    <p>1969</p> Signup and view all the answers

    What is the primary method for laboratory diagnosis of rubella?

    <p>Serology</p> Signup and view all the answers

    What is the primary manifestation of congenital rubella syndrome in infants?

    <p>Hearing loss</p> Signup and view all the answers

    What is the primary characteristic of treatment for congenital rubella syndrome?

    <p>Mainly supportive</p> Signup and view all the answers

    What is the primary method for active immunization against rubella?

    <p>Subcutaneous injection</p> Signup and view all the answers

    What is the primary risk factor for measles in infants in third world countries?

    <p>Gestational age</p> Signup and view all the answers

    What is the primary characteristic of the measles-rubella vaccine's contraindications?

    <p>Contraindicated in pregnancy</p> Signup and view all the answers

    What is the primary characteristic of the accidental vaccinations in susceptible pregnant women?

    <p>No clinical adverse effects on the mother</p> Signup and view all the answers

    What is the primary cellular receptor to which the measles virus attaches?

    <p>CD-46</p> Signup and view all the answers

    Which of the following is a characteristic sign of measles infection?

    <p>Koplik’s spots</p> Signup and view all the answers

    What is the incubation period for measles?

    <p>10-12 days</p> Signup and view all the answers

    What is the primary cause of generalized immunosuppression following measles infection?

    <p>Decreased interleukin production</p> Signup and view all the answers

    Which family does the measles virus belong to?

    <p>Paramyxoviridae</p> Signup and view all the answers

    What is the primary mode of transmission for the measles virus?

    <p>Respiratory secretions</p> Signup and view all the answers

    What is the major cause of measles-related mortality among young children?

    <p>Opportunistic infections</p> Signup and view all the answers

    What is the characteristic feature of measles virus replication?

    <p>Giant multinucleated cells and syncytium formation</p> Signup and view all the answers

    What is the only known natural species recognized to be infected by the measles virus?

    <p>Humans</p> Signup and view all the answers

    What is the primary cause of measles-related death in immunocompromised individuals?

    <p>Secondary bacterial infections</p> Signup and view all the answers

    What is the primary method for tracking outbreaks and identifying significant antigenic drifts in measles virus strains?

    <p>Molecular surveillance</p> Signup and view all the answers

    What is the primary method for preventing measles?

    <p>Vaccination</p> Signup and view all the answers

    What is the mean incubation period for measles?

    <p>7-14 days</p> Signup and view all the answers

    What is the primary site of initial measles virus replication?

    <p>Tracheal and bronchial epithelial cells</p> Signup and view all the answers

    What is the characteristic appearance of Koplik’s spots in measles?

    <p>Resembles grain of salt just beneath the mucosa</p> Signup and view all the answers

    What is the primary cause of most measles-related deaths?

    <p>Complications such as pneumonia and encephalitis</p> Signup and view all the answers

    What is the significance of the presence of humoral antibodies in measles immunity?

    <p>Suggests a satisfactory immune response</p> Signup and view all the answers

    What is the characteristic of the exanthem period in measles?

    <p>Clear sign of immune response and recovery</p> Signup and view all the answers

    What is the primary method for preventing measles?

    <p>Vaccination with MMR (Measles, Mumps, Rubella) vaccine</p> Signup and view all the answers

    What is the primary mode of transmission for measles?

    <p>Respiratory droplets</p> Signup and view all the answers

    What is the primary cause of immune suppression following measles infection?

    <p>Viral invasion of lymphocytes</p> Signup and view all the answers

    What is the primary characteristic of atypical measles?

    <p>Occurs in partially immune persons</p> Signup and view all the answers

    What is the distribution of measles worldwide?

    <p>Endemic in many developing countries</p> Signup and view all the answers

    What are some common complications of measles?

    <p>Pneumonia, encephalitis, and giant cell pneumonia</p> Signup and view all the answers

    Which of the following is a characteristic of subacute sclerosing panencephalitis (SSPE)?

    <p>Onset of behavioral and intellectual deterioration occurs years after an acute measles infection</p> Signup and view all the answers

    What is the primary method for diagnosing measles?

    <p>Serology (ELISA)</p> Signup and view all the answers

    What is the primary mode of transmission for measles virus?

    <p>Respiratory droplets</p> Signup and view all the answers

    What is the characteristic of humoral immune response to measles infection?

    <p>Production of IgM, IgA, and IgG antibodies</p> Signup and view all the answers

    What is the mean incubation period for measles?

    <p>1-3 weeks</p> Signup and view all the answers

    What is the primary habitat of the measles virus?

    <p>Human</p> Signup and view all the answers

    What is the most common cause of measles-related deaths?

    <p>Secondary infections due to immune suppression</p> Signup and view all the answers

    What is the distribution of measles worldwide?

    <p>Endemic in countries with large populations of susceptible children</p> Signup and view all the answers

    What is the characteristic of the exanthem period in measles?

    <p>Appearance of maculopapular rash</p> Signup and view all the answers

    What is the primary symptom of measles infection during the prodromal period?

    <p>Cough, coryza, and conjunctivitis</p> Signup and view all the answers

    What is essential for tracking outbreaks and identifying significant antigenic variations in measles virus strains?

    <p>Genetic determination of the virus</p> Signup and view all the answers

    What is the cause of serious secondary infections in measles?

    <p>Immune suppression</p> Signup and view all the answers

    Which of the following statements about measles vaccine is correct?

    <p>Measles vaccine is a type of live attenuated vaccine that starts at 6 to 9 months of age.</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Mumps V antigen and S antigen?

    <p>Mumps V antigen and S antigen both consist predominantly of nucleoprotein (NP).</p> Signup and view all the answers

    Which of the following is NOT true regarding Rubella?

    <p>Also known as measles.</p> Signup and view all the answers

    During which stage of pregnancy does organogenesis period happen?

    <p>First 8 weeks of pregnancy.</p> Signup and view all the answers

    Which of the following are complications associated with mumps?

    <p>Blindness.</p> Signup and view all the answers

    Which method of laboratory diagnosis can be used to detect viral mumps RNA and fosters a rapid confirmation for the diagnosis?

    <p>PCR.</p> Signup and view all the answers

    Which of the following does not belong to the classical triad of Rubella in infected neonates?

    <p>Congenital defects.</p> Signup and view all the answers

    Which heart-related disease in congenital rubella syndrome is due to the abnormal development of the fetal heart during the first 8 weeks of pregnancy?

    <p>Pulmonary Atresia.</p> Signup and view all the answers

    Which of the following statements about primary and secondary viremia is correct?

    <p>Both statements are incorrect.</p> Signup and view all the answers

    The presence of this component differentiates mumps from measles virus.

    <p>Neuraminidase.</p> Signup and view all the answers

    Study Notes

    Arboviruses and Their Characteristics

    • Aedes is an arthropod vector of the Rift Valley Fever virus, diagnosed using RT-PCR, ELISA, and culture from blood and tissues samples.
    • There is no FDA-approved treatment for Rift Valley Fever, and prevention methods include avoiding contact with infected animals and protecting against mosquitoes.
    • Flaviviridae causes a wide range of clinical symptoms, including hemorrhagic fever and encephalitis, and is spread by a mosquito vector affecting humans and birds.
    • Japanese Encephalitis, a flavivirus transmitted by Culex mosquitoes, was first discovered in Japan and large-scale epidemics occur in China, India, and other parts of Asia.
    • Yellow Fever virus, also a flavivirus, is mainly found in West Africa and South America, with two major forms: Urban and Jungle (sylvatic) yellow fever.
    • Most human infections of Japanese Encephalitis are subclinical, but in clinical cases, life-threatening encephalitis occurs.
    • Dengue, known as "break-bone fever," is a mosquito-borne febrile illness primarily occurring in tropical and subtropical regions, with four main serotypes.
    • Dengue infection with another serotype, especially serotype 2, predisposes individuals to dengue hemorrhagic fever, causing hemorrhage or shock, especially in children.
    • There is no specific therapy for Japanese Encephalitis, but a vaccine is available, while dengue diagnosis involves serology tests and no specific therapy is available, but a vaccine is available.
    • Dengue has a history dating back to 1779-1780, with a pandemic beginning in Southeast Asia after World War II, and it is currently present in Africa, the Americas, Asia, the Caribbean, and the Pacific.
    • The two cycles of dengue are the Jungle Cycle (Sylvatic/Enzootic) and the Urban Cycle (Epidemic), and in the Philippines, 893 new dengue cases were reported in epidemiologic week 2023, with a total of 111,813 cases reported as of August 26, 2023.
    • In 2020, France and Italy reported autochthonous dengue cases, and the five countries reporting the most cases were Brazil, Paraguay, Mexico, Vietnam, and Malaysia.

    Measles Virus: Structure, Replication, and Clinical Presentation

    • Measles remains a leading cause of death among young children, causing 6 million deaths annually, with 164,000 deaths in 2008, mostly in children under 5.
    • Measles is caused by the Paramyxovirus, belonging to the family Paramyxoviridae, and primarily affects humans through respiratory secretions.
    • The virus encodes at least 6 virion structural proteins, including Nucleoprotein (N), Viral Polymerase Protein (P and L), Hemagglutinin (H), Fusion (F), and Matrix (M) proteins.
    • Measles virus attaches to the CD-46 cellular receptor and undergoes a process of attachment, penetration, uncoating, transcription, translation, and RNA replication during viral replication.
    • The clinical presentation of measles includes an incubation period of 10 to 12 days, followed by a prodromal period with symptoms such as high fever, cough, coryza, and conjunctivitis.
    • The appearance of Koplik’s spots, a maculopapular rash, and subsequent desquamation of the skin are characteristic signs of measles infection.
    • Measles virus infection causes generalized immunosuppression, leading to a decrease in delayed type hypersensitivity, interleukin production, and antigen-specific lymphoproliferative responses.
    • Immunocompromised individuals are predisposed to secondary opportunistic infections, such as bronchopneumonia, a major cause of measles-related mortality among young children.
    • The measles virus is only known to infect humans and is recognized by a single serotype, with subtle antigenic and genetic variations among wild-type strains.
    • The virus is transmitted through respiratory secretions, mainly via coughing and sneezing, and can cause serious disease in natural species such as seals, dolphins, and horses.
    • Measles virus replication leads to the formation of giant multinucleated cells and syncytium formation, characterized by intranuclear inclusions and viral protein synthesis.
    • Ongoing molecular surveillance is essential for tracking outbreaks and identifying significant antigenic drifts in measles virus strains.

    Measles Virus: Structure, Replication, and Clinical Presentation

    • Measles remains a leading cause of death among young children, causing 6 million deaths annually, with 164,000 deaths in 2008, mostly in children under 5.
    • Measles is caused by the Paramyxovirus, belonging to the family Paramyxoviridae, and primarily affects humans through respiratory secretions.
    • The virus encodes at least 6 virion structural proteins, including Nucleoprotein (N), Viral Polymerase Protein (P and L), Hemagglutinin (H), Fusion (F), and Matrix (M) proteins.
    • Measles virus attaches to the CD-46 cellular receptor and undergoes a process of attachment, penetration, uncoating, transcription, translation, and RNA replication during viral replication.
    • The clinical presentation of measles includes an incubation period of 10 to 12 days, followed by a prodromal period with symptoms such as high fever, cough, coryza, and conjunctivitis.
    • The appearance of Koplik’s spots, a maculopapular rash, and subsequent desquamation of the skin are characteristic signs of measles infection.
    • Measles virus infection causes generalized immunosuppression, leading to a decrease in delayed type hypersensitivity, interleukin production, and antigen-specific lymphoproliferative responses.
    • Immunocompromised individuals are predisposed to secondary opportunistic infections, such as bronchopneumonia, a major cause of measles-related mortality among young children.
    • The measles virus is only known to infect humans and is recognized by a single serotype, with subtle antigenic and genetic variations among wild-type strains.
    • The virus is transmitted through respiratory secretions, mainly via coughing and sneezing, and can cause serious disease in natural species such as seals, dolphins, and horses.
    • Measles virus replication leads to the formation of giant multinucleated cells and syncytium formation, characterized by intranuclear inclusions and viral protein synthesis.
    • Ongoing molecular surveillance is essential for tracking outbreaks and identifying significant antigenic drifts in measles virus strains.

    Measles Virus: Structure, Replication, and Clinical Presentation

    • Measles remains a leading cause of death among young children, causing 6 million deaths annually, with 164,000 deaths in 2008, mostly in children under 5.
    • Measles is caused by the Paramyxovirus, belonging to the family Paramyxoviridae, and primarily affects humans through respiratory secretions.
    • The virus encodes at least 6 virion structural proteins, including Nucleoprotein (N), Viral Polymerase Protein (P and L), Hemagglutinin (H), Fusion (F), and Matrix (M) proteins.
    • Measles virus attaches to the CD-46 cellular receptor and undergoes a process of attachment, penetration, uncoating, transcription, translation, and RNA replication during viral replication.
    • The clinical presentation of measles includes an incubation period of 10 to 12 days, followed by a prodromal period with symptoms such as high fever, cough, coryza, and conjunctivitis.
    • The appearance of Koplik’s spots, a maculopapular rash, and subsequent desquamation of the skin are characteristic signs of measles infection.
    • Measles virus infection causes generalized immunosuppression, leading to a decrease in delayed type hypersensitivity, interleukin production, and antigen-specific lymphoproliferative responses.
    • Immunocompromised individuals are predisposed to secondary opportunistic infections, such as bronchopneumonia, a major cause of measles-related mortality among young children.
    • The measles virus is only known to infect humans and is recognized by a single serotype, with subtle antigenic and genetic variations among wild-type strains.
    • The virus is transmitted through respiratory secretions, mainly via coughing and sneezing, and can cause serious disease in natural species such as seals, dolphins, and horses.
    • Measles virus replication leads to the formation of giant multinucleated cells and syncytium formation, characterized by intranuclear inclusions and viral protein synthesis.
    • Ongoing molecular surveillance is essential for tracking outbreaks and identifying significant antigenic drifts in measles virus strains.

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    Arbovirus Lesson 24B PDF

    Description

    Test your knowledge of arboviruses and their characteristics with this quiz. Explore topics such as transmission vectors, geographic distribution, clinical symptoms, and diagnostic methods for arboviral diseases such as Rift Valley Fever, Japanese Encephalitis, Yellow Fever, and Dengue.

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