Apoptosis Pathway and Mechanisms Quiz
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Questions and Answers

Apoptosis leads to cell shrinkage and increased density of cytoplasm.

True

Tumors are resistant to apoptosis during their active growth phase.

False

ER stress is the basis of degenerative diseases in the cardiovascular system.

False

Viral infections like HIV and Hepatitis can lead to cell death through apoptosis.

<p>True</p> Signup and view all the answers

Apoptotic bodies are usually phagocytosed by neutrophils.

<p>False</p> Signup and view all the answers

Radiation and cytotoxic drugs can cause DNA damage leading to apoptosis.

<p>True</p> Signup and view all the answers

Apoptosis is a pathway of cell death that is induced by a tightly regulated suicide program.

<p>True</p> Signup and view all the answers

Necrosis and apoptosis have similar features.

<p>False</p> Signup and view all the answers

Apoptotic cells always elicit an inflammatory reaction.

<p>False</p> Signup and view all the answers

Apoptosis occurs only in pathologic conditions.

<p>False</p> Signup and view all the answers

Hormone-dependent involution is an example of a physiologic cause of apoptosis.

<p>True</p> Signup and view all the answers

Apoptosis is a random process that occurs without any regulation.

<p>False</p> Signup and view all the answers

Necrosis is characterized by reduced cell size and intact plasma membrane.

<p>False</p> Signup and view all the answers

In apoptosis, cellular contents undergo enzymatic digestion and may leak out of the cell.

<p>False</p> Signup and view all the answers

Apoptosis involves a reduction in cell size, brightly eosinophilic cytoplasm, and a condensed nucleus.

<p>True</p> Signup and view all the answers

Necrosis is invariably a physiologic process.

<p>False</p> Signup and view all the answers

Protein cleavage in apoptosis is carried out by protease 'caspases'.

<p>True</p> Signup and view all the answers

Apoptosis is a means of eliminating unwanted cells.

<p>True</p> Signup and view all the answers

Apoptotic bodies are formed when cytoplasmic proteins swell and expand.

<p>False</p> Signup and view all the answers

Signals from plasma membrane receptors in the death receptor pathway lead to the activation of executioner caspases.

<p>True</p> Signup and view all the answers

Apoptosis is also known as necrosis.

<p>False</p> Signup and view all the answers

DNA breakdown in apoptosis is mainly mediated by exo-nucleases.

<p>False</p> Signup and view all the answers

The two main pathways of apoptosis are the Death receptor Pathway and the Endoplasmic Reticulum Pathway.

<p>False</p> Signup and view all the answers

Imbalance in the BCL2 family of proteins can lead to leakage of pro-apoptotic substances from the nucleus.

<p>False</p> Signup and view all the answers

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