24 Questions
Apoptosis leads to cell shrinkage and increased density of cytoplasm.
True
Tumors are resistant to apoptosis during their active growth phase.
False
ER stress is the basis of degenerative diseases in the cardiovascular system.
False
Viral infections like HIV and Hepatitis can lead to cell death through apoptosis.
True
Apoptotic bodies are usually phagocytosed by neutrophils.
False
Radiation and cytotoxic drugs can cause DNA damage leading to apoptosis.
True
Apoptosis is a pathway of cell death that is induced by a tightly regulated suicide program.
True
Necrosis and apoptosis have similar features.
False
Apoptotic cells always elicit an inflammatory reaction.
False
Apoptosis occurs only in pathologic conditions.
False
Hormone-dependent involution is an example of a physiologic cause of apoptosis.
True
Apoptosis is a random process that occurs without any regulation.
False
Necrosis is characterized by reduced cell size and intact plasma membrane.
False
In apoptosis, cellular contents undergo enzymatic digestion and may leak out of the cell.
False
Apoptosis involves a reduction in cell size, brightly eosinophilic cytoplasm, and a condensed nucleus.
True
Necrosis is invariably a physiologic process.
False
Protein cleavage in apoptosis is carried out by protease 'caspases'.
True
Apoptosis is a means of eliminating unwanted cells.
True
Apoptotic bodies are formed when cytoplasmic proteins swell and expand.
False
Signals from plasma membrane receptors in the death receptor pathway lead to the activation of executioner caspases.
True
Apoptosis is also known as necrosis.
False
DNA breakdown in apoptosis is mainly mediated by exo-nucleases.
False
The two main pathways of apoptosis are the Death receptor Pathway and the Endoplasmic Reticulum Pathway.
False
Imbalance in the BCL2 family of proteins can lead to leakage of pro-apoptotic substances from the nucleus.
False
Test your understanding of apoptosis, including the definition, causes, mechanisms, and differences with necrosis. This quiz is based on learning outcomes from the Manipal University College Malaysia Block 1 curriculum.
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