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Questions and Answers
Match the following apoptosis mechanisms with their descriptions:
Match the following apoptosis mechanisms with their descriptions:
Intrinsic pathway = Triggered by extracellular signals Extrinsic pathway = Mediated by mitochondria, involves the release of cytochrome c Permeabilization of the mitochondrial outer membrane = Allows cytochrome c to be released into the cytosol, leading to caspase activation Caspase cascade = A series of proteolytic reactions that ultimately lead to the execution of apoptosis
Match the following cell death pathways with their characteristics:
Match the following cell death pathways with their characteristics:
Apoptosis = Characterized by cell swelling, lysis, and inflammation Necrosis = A regulated process of cell death, characterized by cell shrinkage, nuclear condensation, and DNA fragmentation Autophagic cell death = A type of cell death that involves the digestion of cellular components by autophagosomes Ferroptosis = A type of cell death characterized by the accumulation of lipid peroxides and the inhibition of glutathione synthesis
Match the following Bcl-2 family proteins with their functions:
Match the following Bcl-2 family proteins with their functions:
Bax = Regulates apoptosis by controlling mitochondrial permeabilization Bak = Inhibits apoptosis by blocking mitochondrial permeabilization Bcl-2 = Induces apoptosis by activating caspase-9 Bcl-xL = Regulates apoptosis by controlling the release of cytochrome c
Match the following nuclear morphology in cell death with their descriptions:
Match the following nuclear morphology in cell death with their descriptions:
Match the following cell death pathways with their mechanisms:
Match the following cell death pathways with their mechanisms:
Match the following apoptosis mechanisms with their effects:
Match the following apoptosis mechanisms with their effects:
Match the following cell death pathways with their characteristics:
Match the following cell death pathways with their characteristics:
Match the following nuclear morphology in cell death with their characteristics:
Match the following nuclear morphology in cell death with their characteristics:
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Study Notes
Apoptosis Mechanisms
- Intrinsic pathway: mediated by mitochondria, involves the release of cytochrome c and activation of caspase-9
- Extrinsic pathway: triggered by extracellular signals, such as Fas ligand, and activates caspase-8
- Permeabilization of the mitochondrial outer membrane: allows cytochrome c to be released into the cytosol, leading to caspase activation
- Caspase cascade: a series of proteolytic reactions that ultimately lead to the execution of apoptosis
- Bcl-2 family proteins: regulate apoptosis by controlling mitochondrial permeabilization (e.g., Bax, Bak, Bcl-2, Bcl-xL)
Cell Death Pathways
- Apoptosis: a regulated process of cell death, characterized by cell shrinkage, nuclear condensation, and DNA fragmentation
- Necrosis: an unregulated process of cell death, characterized by cell swelling, lysis, and inflammation
- Autophagic cell death: a type of cell death that involves the digestion of cellular components by autophagosomes
- Ferroptosis: a type of cell death characterized by the accumulation of lipid peroxides and the inhibition of glutathione synthesis
- Pyroptosis: a type of cell death that involves the activation of caspase-1 and the release of pro-inflammatory cytokines
Nuclear Morphology in Cell Death
- Chromatin condensation: a hallmark of apoptosis, characterized by the compaction of chromatin into distinct, densely staining structures
- Nuclear fragmentation: the breakdown of the nucleus into smaller, membrane-bound fragments
- Nuclear shrinkage: a reduction in nuclear size, often accompanied by chromatin condensation
- Pyknosis: a type of nuclear morphology characterized by intense chromatin condensation and nuclear shrinkage
Apoptosis Mechanisms
- Intrinsic pathway is mediated by mitochondria, involving the release of cytochrome c and activation of caspase-9, leading to apoptosis.
- Extrinsic pathway is triggered by extracellular signals, such as Fas ligand, and activates caspase-8, initiating the apoptotic process.
- Mitochondrial outer membrane permeabilization allows cytochrome c to be released into the cytosol, leading to caspase activation and subsequent apoptosis.
- Caspase cascade is a series of proteolytic reactions that ultimately lead to the execution of apoptosis.
- Bcl-2 family proteins (Bax, Bak, Bcl-2, Bcl-xL) regulate apoptosis by controlling mitochondrial permeabilization.
Cell Death Pathways
- Apoptosis is a regulated process of cell death, characterized by cell shrinkage, nuclear condensation, and DNA fragmentation.
- Necrosis is an unregulated process of cell death, characterized by cell swelling, lysis, and inflammation.
- Autophagic cell death is a type of cell death that involves the digestion of cellular components by autophagosomes.
- Ferroptosis is a type of cell death characterized by the accumulation of lipid peroxides and the inhibition of glutathione synthesis.
- Pyroptosis is a type of cell death that involves the activation of caspase-1 and the release of pro-inflammatory cytokines.
Nuclear Morphology in Cell Death
- Chromatin condensation is a hallmark of apoptosis, characterized by the compaction of chromatin into distinct, densely staining structures.
- Nuclear fragmentation is the breakdown of the nucleus into smaller, membrane-bound fragments.
- Nuclear shrinkage is a reduction in nuclear size, often accompanied by chromatin condensation.
- Pyknosis is a type of nuclear morphology characterized by intense chromatin condensation and nuclear shrinkage.
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