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Questions and Answers
What did Paul Ehrlich first describe in 1888?
What did Paul Ehrlich first describe in 1888?
- Iron deficiency anemia
- Hemolytic anemia
- Sickle cell anemia
- Aplastic anemia (correct)
What characterizes hypoproliferative disorders?
What characterizes hypoproliferative disorders?
- Reduced growth or production of blood cells (correct)
- Abnormal shape of blood cells
- Increased growth of blood cells
- Excessive destruction of blood cells
What is the most common cause of acquired aplastic anemia?
What is the most common cause of acquired aplastic anemia?
- Immune-mediated destruction of hematopoiesis (correct)
- Viral infection
- Genetic predisposition
- Chemical exposure
What is the term for a congenital or genetic predisposition to bone marrow failure?
What is the term for a congenital or genetic predisposition to bone marrow failure?
Which agents are considered to cause iatrogenic aplastic anemia?
Which agents are considered to cause iatrogenic aplastic anemia?
Which of the following is a characteristic of hypoproliferative disorders?
Which of the following is a characteristic of hypoproliferative disorders?
What is the most common cause of acquired aplastic anemia?
What is the most common cause of acquired aplastic anemia?
What distinguishes idiopathic aplastic anemia?
What distinguishes idiopathic aplastic anemia?
Which deficiency is not included in the anemias characterized by reduced growth or production of blood cells?
Which deficiency is not included in the anemias characterized by reduced growth or production of blood cells?
What are the etiologic agents considered to cause iatrogenic aplastic anemia?
What are the etiologic agents considered to cause iatrogenic aplastic anemia?
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Study Notes
Historical Background
- Paul Ehrlich first described aplastic anemia in 1888.
Hypoproliferative Disorders
- Hypoproliferative disorders are characterized by a normal or decreased reticulocyte count.
- Hypoproliferative disorders are accompanied by erythropoietic insufficiency.
Aplastic Anemia
- The most common cause of acquired aplastic anemia is radiation and chemotherapy.
- Idiopathic aplastic anemia is distinguished by the absence of a known cause.
- Inherited bone marrow failure syndromes are a congenital or genetic predisposition to bone marrow failure, also known as Fanconi anemia.
Iatrogenic Aplastic Anemia
- Chemotherapeutic agents, ionizing radiation, and benzene are considered to cause iatrogenic aplastic anemia.
Anemias
- Vitamin B12 and folate deficiencies are included in the anemias characterized by reduced growth or production of blood cells.
- Iron deficiency is not included in the anemias characterized by reduced growth or production of blood cells.
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