Aplastic Anemia
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Questions and Answers

Which of the following is a distinguishing feature of acquired aplastic anemia?

  • Onset in early childhood
  • Presence of typical physical anomalies
  • Abrupt onset of low blood counts in a previously well young adult (correct)
  • Marrow hypocellularity after intensive cytotoxic chemotherapy for cancer

    • Which genetic disease usually presents in early childhood and has typical physical anomalies?

  • RUNX1 mutation
  • Dyskeratosis congenita
  • Fanconi anemia (correct)
  • GATA2 mutation

    • What can cause marrow hypocellularity in aplastic anemia?

  • Iatrogenic aplasia
  • Radiation poisoning
  • Chemotherapy for cancer (correct)
  • Genetic diseases

    • Which of the following can present as marrow failure in normal-appearing adults?

    <p>Telomere diseases</p> Signup and view all the answers

    What is a common manifestation of acquired aplastic anemia?

    <p>Seronegative hepatitis</p> Signup and view all the answers

    Which of the following is a distinguishing feature of acquired aplastic anemia?

    <p>Abrupt onset of low blood counts in a previously well young adult</p> Signup and view all the answers

    What is a common manifestation of acquired aplastic anemia?

    <p>Seronegative hepatitis</p> Signup and view all the answers

    What can cause marrow hypocellularity in aplastic anemia?

    <p>Accidental physical and chemical injury</p> Signup and view all the answers

    Which genetic disease usually presents in early childhood and has typical physical anomalies?

    <p>Fanconi anemia</p> Signup and view all the answers

    Which of the following can present as marrow failure in normal-appearing adults?

    <p>Genetic mutations in GATA2, RUNX1, and MPL genes</p> Signup and view all the answers

    Which of the following is a distinguishing feature of acquired aplastic anemia?

    <p>Onset of low blood counts in a previously well young adult</p> Signup and view all the answers

    Which genetic disease usually presents in early childhood and has typical physical anomalies?

    <p>Fanconi anemia</p> Signup and view all the answers

    What can cause marrow hypocellularity in aplastic anemia?

    <p>Accidental physical and chemical injury</p> Signup and view all the answers

    Which of the following can present as marrow failure in normal-appearing adults?

    <p>Telomere diseases</p> Signup and view all the answers

    What is a common manifestation of acquired aplastic anemia?

    <p>Moderate or incomplete blood count depression</p> Signup and view all the answers

    What are the distinguishing features of acquired aplastic anemia?

    <p>Abrupt onset of low blood counts in a previously well young adult, seronegative hepatitis or a course of an incriminated medical drug may precede the onset.</p> Signup and view all the answers

    What are some genetic diseases that can present as marrow failure in normal-appearing adults?

    <p>Telomere diseases and hematologic manifestations of mutations in genes such as GATA2, RUNX1, and MPL.</p> Signup and view all the answers

    What are some genetic diseases that usually present in early childhood and have typical physical anomalies?

    <p>Fanconi anemia and dyskeratosis congenita.</p> Signup and view all the answers

    What is pancytopenia?

    <p>Low blood counts of red blood cells, white blood cells, and platelets.</p> Signup and view all the answers

    What can cause bone marrow hypocellularity in aplastic anemia?

    <p>Acquired aplastic anemia can be caused by iatrogenic aplasia, physical and chemical injury, as in radiation poisoning, or it can be constitutional.</p> Signup and view all the answers

    Study Notes

    Acquired Aplastic Anemia

    • Distinguishing feature: marrow hypocellularity, which can be caused by radiation, chemotherapy, and toxins
    • Common manifestation: pancytopenia, a condition characterized by a decrease in all three types of blood cells (red, white, and platelets)

    Genetic Diseases

    • Fanconi anemia: usually presents in early childhood, has typical physical anomalies, and can present as marrow failure in normal-appearing adults
    • Dyskeratosis congenita: usually presents in early childhood, has typical physical anomalies, and can present as marrow failure in normal-appearing adults

    Marrow Failure

    • Can be caused by acquired aplastic anemia, which is a condition where the bone marrow fails to produce enough blood cells
    • Can be caused by genetic diseases, such as Fanconi anemia and Dyskeratosis congenita, which usually present in early childhood and have typical physical anomalies

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    Description

    Test your knowledge on Aplastic Anemia and its various forms, including acquired and constitutional types. Learn about the causes, symptoms, and genetic diseases associated with this condition.

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