20 Questions
Which of the following is a distinguishing feature of acquired aplastic anemia?
Abrupt onset of low blood counts in a previously well young adult
Which genetic disease usually presents in early childhood and has typical physical anomalies?
Fanconi anemia
What can cause marrow hypocellularity in aplastic anemia?
Chemotherapy for cancer
Which of the following can present as marrow failure in normal-appearing adults?
Telomere diseases
What is a common manifestation of acquired aplastic anemia?
Seronegative hepatitis
Which of the following is a distinguishing feature of acquired aplastic anemia?
Abrupt onset of low blood counts in a previously well young adult
What is a common manifestation of acquired aplastic anemia?
Seronegative hepatitis
What can cause marrow hypocellularity in aplastic anemia?
Accidental physical and chemical injury
Which genetic disease usually presents in early childhood and has typical physical anomalies?
Fanconi anemia
Which of the following can present as marrow failure in normal-appearing adults?
Genetic mutations in GATA2, RUNX1, and MPL genes
Which of the following is a distinguishing feature of acquired aplastic anemia?
Onset of low blood counts in a previously well young adult
Which genetic disease usually presents in early childhood and has typical physical anomalies?
Fanconi anemia
What can cause marrow hypocellularity in aplastic anemia?
Accidental physical and chemical injury
Which of the following can present as marrow failure in normal-appearing adults?
Telomere diseases
What is a common manifestation of acquired aplastic anemia?
Moderate or incomplete blood count depression
What are the distinguishing features of acquired aplastic anemia?
Abrupt onset of low blood counts in a previously well young adult, seronegative hepatitis or a course of an incriminated medical drug may precede the onset.
What are some genetic diseases that can present as marrow failure in normal-appearing adults?
Telomere diseases and hematologic manifestations of mutations in genes such as GATA2, RUNX1, and MPL.
What are some genetic diseases that usually present in early childhood and have typical physical anomalies?
Fanconi anemia and dyskeratosis congenita.
What is pancytopenia?
Low blood counts of red blood cells, white blood cells, and platelets.
What can cause bone marrow hypocellularity in aplastic anemia?
Acquired aplastic anemia can be caused by iatrogenic aplasia, physical and chemical injury, as in radiation poisoning, or it can be constitutional.
Study Notes
Acquired Aplastic Anemia
- Distinguishing feature: marrow hypocellularity, which can be caused by radiation, chemotherapy, and toxins
- Common manifestation: pancytopenia, a condition characterized by a decrease in all three types of blood cells (red, white, and platelets)
Genetic Diseases
- Fanconi anemia: usually presents in early childhood, has typical physical anomalies, and can present as marrow failure in normal-appearing adults
- Dyskeratosis congenita: usually presents in early childhood, has typical physical anomalies, and can present as marrow failure in normal-appearing adults
Marrow Failure
- Can be caused by acquired aplastic anemia, which is a condition where the bone marrow fails to produce enough blood cells
- Can be caused by genetic diseases, such as Fanconi anemia and Dyskeratosis congenita, which usually present in early childhood and have typical physical anomalies
Test your knowledge on Aplastic Anemia and its various forms, including acquired and constitutional types. Learn about the causes, symptoms, and genetic diseases associated with this condition.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
