Questions and Answers
Describe the bicarbonate buffer system and explain its importance in regulating pH changes.
The bicarbonate buffer system is a solution containing carbonic acid and sodium bicarbonate. When sodium bicarbonate comes in contact with a strong acid, carbonic acid and NaCl are formed. This process removes hydrogen ions, causing the pH to rise and become more basic.
Explain the renin-angiotensin-aldosterone mechanism.
Renin is released, activating angiotensinogen to angiotensin 1, then ACE converts it to angiotensin 2, resulting in constriction of blood vessels and a higher blood pressure.
Identify the four ways in which angiotensin II is able to increase blood pressure.
- Adrenal cortex releases aldosterone. 2. Angiotensin activates thirst response. 3. Vasoconstriction. 4. Increased sodium reabsorption by the renal tubules.
Explain how aldosterone influences water balance in the body.
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Briefly explain how urine is concentrated.
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Name two causes of metabolic acidosis and two causes of metabolic alkalosis.
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Explain the three ways PTH increases Ca2+ levels in the blood.
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Explain the three types of buffering systems in the body and rank them from fastest to slowest.
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What is the hydrostatic pressure in the glomerular capsule?
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What does hydrostatic pressure in the capsular space refer to?
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What is osmotic pressure in the glomerular capsule?
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Define net filtration pressure.
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Study Notes
Bicarbonate Buffer System
- Comprises carbonic acid and sodium bicarbonate.
- Neutralizes strong acids by forming carbonic acid and NaCl, thereby raising pH and promoting basicity.
Renin-Angiotensin-Aldosterone Mechanism
- Renin release activates angiotensinogen to produce angiotensin I.
- Angiotensin I converts to angiotensin II via ACE, leading to blood vessel constriction and raised blood pressure.
Angiotensin II and Blood Pressure
- Stimulates adrenal cortex to release aldosterone.
- Activates thirst response to encourage fluid intake.
- Causes vasoconstriction to increase vascular resistance.
- Promotes renal tubules' sodium reabsorption, enhancing fluid retention.
Aldosterone and Water Balance
- Stimulates sodium reabsorption in distal convoluted tubule (DCT).
- Water follows absorbed sodium, conserving body water when hydration is low.
Urine Concentration and Survival Without Water
- Antidiuretic hormone (ADH) elevates water uptake and reduces urine output.
- ADH increases permeability of collecting duct membranes for water via osmosis.
- Concentration occurs in the nephron loop and involves the medullary gradient.
Metabolic Acidosis and Alkalosis Causes
- Metabolic Acidosis: Excess alcohol consumption, lactic acid buildup from exercise or shock.
- Metabolic Alkalosis: Loss of stomach acid through vomiting, excessive antacid intake.
Parathyroid Hormone (PTH) and Calcium Levels
- Promotes bone breakdown, releasing calcium and hydrogen phosphate.
- Enhances calcium reabsorption in renal tubules while limiting phosphate reabsorption.
- Stimulates kidney to convert vitamin D into its active form for better intestinal calcium absorption.
Buffering Systems in the Body
- Chemical Buffering: Immediate response to pH changes; quickest line of defense.
- Respiratory Buffering: Modulates breath rate and depth within 1-3 minutes to adjust blood pH.
- Renal Buffering: Kidneys regulate pH changes; slower response, takes days for effects.
Hydrostatic Pressure in Glomerular Capsule
- Primary force pushing water and solutes from blood across filtration membrane.
Hydrostatic Pressure in Capsular Space
- Refers to fluid pressure exerted upward against the capillaries.
Osmotic Pressure in Glomerular Capsule
- Minimum pressure necessary to prevent pure solvent from entering across a semipermeable membrane.
Net Filtration Pressure
- Calculated by subtracting net osmotic pressure and hydrostatic pressure from net hydrostatic pressure.
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Test your understanding of key concepts in Anatomy and Physiology with these flashcards focused on Unit 3. These include important topics like the bicarbonate buffer system and the renin-angiotensin system, essential for maintaining pH balance and blood pressure regulation.