10 Questions
Which receptor do anxiolytic drugs predominantly act on?
GABA receptors
What is the main disadvantage of diazepam as a sedative and anxiolytic?
Long elimination half-life
Which benzodiazepine is recommended for oral premedication due to its rapid absorption and anxiolytic action similar to that of morphine?
Diazepam
Why is intramuscular injection of diazepam not recommended?
It is painful
What is the pharmacokinetic property that differs among benzodiazepines?
Duration of action
What makes midazolam a suitable agent for producing conscious sedation?
Its negligible soporific effects
Why are opioids usually the agents of choice in the presence of acute severe pain?
They are usually the most potent analgesic drugs
What is the primary reason for using NSAIDs in day surgery?
To reduce the required dose of anesthetic agent
What is the reason for preferring pethidine over morphine in some cases?
It causes less histamine release
What is the primary effect of clonidine given as a premedication?
To reduce postoperative pain in children
Study Notes
Anxiolytic Drugs and Sedatives
- Anxiolytic drugs predominantly act on the GABA receptor.
- The main disadvantage of diazepam as a sedative and anxiolytic is its long duration of action, leading to prolonged sedation.
Benzodiazepines
- Midazolam is recommended for oral premedication due to its rapid absorption and anxiolytic action similar to that of morphine.
- Diazepam is not recommended for intramuscular injection due to its slow and irregular absorption from the muscle.
- The pharmacokinetic property that differs among benzodiazepines is their half-life.
Conscious Sedation and Pain Management
- Midazolam is a suitable agent for producing conscious sedation due to its short half-life, rapid onset, and offset of action.
- Opioids are usually the agents of choice in the presence of acute severe pain due to their potent analgesic action.
- The primary reason for using NSAIDs in day surgery is to provide postoperative pain relief.
- Pethidine is preferred over morphine in some cases due to its shorter duration of action and less histamine release.
Premedication
- The primary effect of clonidine given as a premedication is to produce sedation and anxiolysis.
Test your knowledge about anxiolytic drugs and their effects on patients. Explore the use of benzodiazepines in decreasing anxiety, inducing sedation, and causing amnesia. Learn about their impact on GABA receptors and potential effects on neonates.
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