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Questions and Answers
What characterizes first-generation antipsychotic drugs?
What characterizes first-generation antipsychotic drugs?
What is a notable difference between first-generation and second-generation antipsychotic drugs?
What is a notable difference between first-generation and second-generation antipsychotic drugs?
What serious side effect is associated with clozapine?
What serious side effect is associated with clozapine?
Which statement about second-generation antipsychotic drugs is true?
Which statement about second-generation antipsychotic drugs is true?
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What aspect of first-generation antipsychotic drugs primarily influences their adverse effect profile?
What aspect of first-generation antipsychotic drugs primarily influences their adverse effect profile?
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Study Notes
Antipsychotic Drugs
- Antipsychotic drugs are categorized into first- and second-generation agents.
- First-generation drugs are further classified as "low-potency" or "high-potency" based on their affinity for the dopamine D2 receptor, not clinical effectiveness.
- First-generation antipsychotics are competitive inhibitors at various receptors, but their antipsychotic action is linked to blocking D2 dopamine receptors.
First-Generation Antipsychotics
- Also called conventional, typical, or traditional antipsychotics.
- Exhibit competitive inhibition at various receptors.
- Antipsychotic effects result from blocking dopamine D2 receptors.
Second-Generation Antipsychotics
- Also known as atypical antipsychotics.
- Associated with fewer extrapyramidal symptoms (EPS) compared to first-generation drugs.
- Have a higher risk of metabolic side effects, including diabetes, hypercholesterolemia, and weight gain.
- Appear to act by blocking both serotonin and dopamine receptors (and possibly others).
- Clozapine is an effective antipsychotic with minimal EPS risk.
- Use is limited to refractory patients due to serious side effects, such as bone marrow suppression, seizures, and cardiovascular issues.
- Clozapine necessitates frequent white blood cell count monitoring due to the risk of severe agranulocytosis.
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Description
This quiz covers the classifications and mechanisms of action of antipsychotic drugs, including first- and second-generation agents. Learn about the specific effects linked to dopamine receptor blocking and the differing side effect profiles of these medications.
