Podcast
Questions and Answers
What structural feature allows antipsychotic agents to form highly hydrophobic esters?
What structural feature allows antipsychotic agents to form highly hydrophobic esters?
- Variety of oils
- Long-chain aliphatic esters
- Free hydroxyl (OH) moiety
- Terminal alcohol group (correct)
Which type of antipsychotic drugs have longer duration of action when prepared as long-chain fatty acid esters?
Which type of antipsychotic drugs have longer duration of action when prepared as long-chain fatty acid esters?
- Neuroleptics with a free hydroxyl (OH) moiety (correct)
- Antipsychotic agents with a terminal alcohol group
- Long-chain aliphatic esters
- Typical antipsychotics – Phenothiazen SAR
What distinguishes fluphenazine enanthate and fluphenazine decanoate from their unesterified precursors in clinical use?
What distinguishes fluphenazine enanthate and fluphenazine decanoate from their unesterified precursors in clinical use?
- Low hydrophobicity
- Longer acting with fewer side effects (correct)
- Less patient compliance needed
- Shorter acting with more side effects
Why are patients treated with fluphenazine enanthate and fluphenazine decanoate less frequently than with their unesterified precursors?
Why are patients treated with fluphenazine enanthate and fluphenazine decanoate less frequently than with their unesterified precursors?
What is the main advantage of treating patients with long-acting antipsychotics like fluphenazine enanthate and fluphenazine decanoate?
What is the main advantage of treating patients with long-acting antipsychotics like fluphenazine enanthate and fluphenazine decanoate?
What is dissolved in a variety of oils to enhance the characteristics of typical antipsychotics like decanoate and palmitate?
What is dissolved in a variety of oils to enhance the characteristics of typical antipsychotics like decanoate and palmitate?
Which antipsychotic agent has a longer duration of action than butyrophenone analogues?
Which antipsychotic agent has a longer duration of action than butyrophenone analogues?
Which typical antipsychotic agent is specifically noted for its usefulness in treating acute exacerbation of schizophrenia and reducing the rate of relapse in chronic schizophrenia patients?
Which typical antipsychotic agent is specifically noted for its usefulness in treating acute exacerbation of schizophrenia and reducing the rate of relapse in chronic schizophrenia patients?
Which benzamide derivative displays relatively low incidence of extrapyramidal side effects (EPS)?
Which benzamide derivative displays relatively low incidence of extrapyramidal side effects (EPS)?
Which second-generation antipsychotic has a more typical neuroleptic biochemical profile with mainly antidopaminergic activity at D2-type receptors?
Which second-generation antipsychotic has a more typical neuroleptic biochemical profile with mainly antidopaminergic activity at D2-type receptors?
Which antipsychotic has a relatively low affinity for brain dopamine D1 and D2 receptors but moderate affinity for D4 receptors?
Which antipsychotic has a relatively low affinity for brain dopamine D1 and D2 receptors but moderate affinity for D4 receptors?
Which butyrophenone derivative is 50 times more potent than chlorpromazine but also produces a higher incidence of extrapyramidal reactions?
Which butyrophenone derivative is 50 times more potent than chlorpromazine but also produces a higher incidence of extrapyramidal reactions?
Which benzamide derivative has poor oral absorption due to hydrophilicity and limited penetration into the central nervous system?
Which benzamide derivative has poor oral absorption due to hydrophilicity and limited penetration into the central nervous system?
Which second-generation antipsychotic agent has a variable half-life ranging from 20 to 50 hours?
Which second-generation antipsychotic agent has a variable half-life ranging from 20 to 50 hours?
Which typical antipsychotic agent is known for its propensity to induce weight gain compared to most atypical antipsychotics?
Which typical antipsychotic agent is known for its propensity to induce weight gain compared to most atypical antipsychotics?
What is the role of endogenous plasma esterases in the action of butyrophenone based antipsychotic drugs?
What is the role of endogenous plasma esterases in the action of butyrophenone based antipsychotic drugs?
What was the primary goal of research aimed at improving the analgesic activity of pethidine?
What was the primary goal of research aimed at improving the analgesic activity of pethidine?
What effect does variation of the X and R groups on the general structure of butyrophenone have on its activity?
What effect does variation of the X and R groups on the general structure of butyrophenone have on its activity?
What is the effect of altering the tertiary amino group on the fourth carbon of the butyrophenone skeleton?
What is the effect of altering the tertiary amino group on the fourth carbon of the butyrophenone skeleton?
What is the result of replacing the ketone with thioketone, olefinic, or phenoxy groups in the butyrophenone structure?
What is the result of replacing the ketone with thioketone, olefinic, or phenoxy groups in the butyrophenone structure?
Which structural feature around the tertiary amine in the butyrophenone structure can be varied?
Which structural feature around the tertiary amine in the butyrophenone structure can be varied?
Which of the following antipsychotics is a benzisothiazole containing agent?
Which of the following antipsychotics is a benzisothiazole containing agent?
Which of the following antipsychotics is an active metabolite of risperidone and has a short time to steady state due to rapid release from nanocrystals?
Which of the following antipsychotics is an active metabolite of risperidone and has a short time to steady state due to rapid release from nanocrystals?
Which of the following antipsychotics has a half-life of 22 hours and is metabolized by hepatic CYP2D6?
Which of the following antipsychotics has a half-life of 22 hours and is metabolized by hepatic CYP2D6?
Which of the following antipsychotics has a half-life of 6 hours and is metabolized to an active metabolite with 9-hydroxy?
Which of the following antipsychotics has a half-life of 6 hours and is metabolized to an active metabolite with 9-hydroxy?
Which of the following antipsychotics is not insoluble in water and does not need co-administration with the oral formulation due to its rapid release from nanocrystals?
Which of the following antipsychotics is not insoluble in water and does not need co-administration with the oral formulation due to its rapid release from nanocrystals?
Which of the following antipsychotics is a 5-HT2A/C/D2 antagonist with relatively high affinity at histamine H1 and adrenergic a1 and a2 receptors?
Which of the following antipsychotics is a 5-HT2A/C/D2 antagonist with relatively high affinity at histamine H1 and adrenergic a1 and a2 receptors?
