25 Questions
What is the primary use of First Generation Antipsychotics?
To reduce positive symptoms effectively
Which of the following is a common adverse effect of First Generation Antipsychotics related to the cardiovascular system?
Orthostatic hypotension
How are First Generation Antipsychotics usually administered?
Orally and through injection
What is a rare but serious reaction associated with First Generation Antipsychotics that can lead to death without treatment?
Neuroleptic malignant syndrome
Which movement disorder can be a late-onset side effect caused by exposure to antipsychotic drugs?
Tardive dyskinesia
What is the black box warning associated with First Generation Antipsychotics in elderly patients with dementia-related psychosis?
Increased mortality due to metabolic effects
Which symptom does Tardive dyskinesia present as?
"Late-onset abnormal movements"
'Depot, long-acting dosage forms for i.m. administration' refers to which aspect of First Generation Antipsychotics?
'Available for injection'
Which type of antipsychotic drugs is generally associated with less extrapyramidal effects?
Second Generation
What is the primary mechanism of action for First Generation antipsychotic drugs?
Blockade of D2 type dopamine receptors
Which symptoms are associated with Cognitive symptoms of Schizophrenia?
Disordered thinking and learning problems
What is the classification basis for First Generation antipsychotics?
Potency levels
Which neurotransmitter receptors are thought to contribute to antipsychotic effects in Second Generation drugs?
D2 type dopamine and serotonin receptors
Which neurotransmitter receptors do all antipsychotic drugs have the potential to block?
Norepinephrine, histamine, and dopamine receptors
Which symptoms characterize the Cognitive symptoms of Schizophrenia?
'Lack of focus' and 'Learning problems'
What is the primary factor that differentiates the potency levels among First Generation antipsychotic drugs?
'Dopamine receptor affinity'
What is the primary symptom of tardive dyskinesia?
Jerky movements of the face with lip smacking and tongue protrusion
How does Valbenazine (Ingrezza) work in treating tardive dyskinesia?
By reducing dopamine release at the synapse
Which class of antipsychotics is known to cause fewer extrapyramidal symptoms like tardive dyskinesia?
Second Generation (Atypical) Antipsychotics
Which antipsychotic is referred to as a 'dopamine stabilizer'?
Aripiprazole
What is a common adverse effect of Second Generation (Atypical) Antipsychotics?
Dyslipidemia
How do Atypical Antipsychotics differ from Conventional Antipsychotics?
They cause fewer extrapyramidal symptoms
'Metabolic effects' commonly associated with Second Generation (Atypical) Antipsychotics include:
Weight gain, dyslipidemia, diabetes
What role does Aripiprazole play in affecting dopamine receptors?
Weak stimulation of dopamine receptors
Which neurotransmitter receptors do Second Generation (Atypical) Antipsychotics typically block?
D2 dopamine and serotonin receptors
Test your knowledge on antipsychotic drugs commonly used to treat psychotic disorders such as schizophrenia and bipolar disorder. Also, explore symptoms of schizophrenia and the classification of first generation antipsychotics based on potency.
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