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Questions and Answers
What is the primary action of oral antiplatelet drugs like aspirin and clopidogrel?
What is the primary action of oral antiplatelet drugs like aspirin and clopidogrel?
- Suppress platelet aggregation (correct)
- Enhance clot formation
- Increase platelet formation
- Inhibit anticoagulant deficiencies
Which of the following is a common consideration before administering oral antiplatelet drugs?
Which of the following is a common consideration before administering oral antiplatelet drugs?
- History of upper GI bleeding (correct)
- Recent use of antibiotics
- Recent surgery for heart disease
- Presence of high blood pressure
What should be monitored during the administration of intravenous antiplatelet drugs?
What should be monitored during the administration of intravenous antiplatelet drugs?
- Daily weight
- CBC and clotting studies (correct)
- Renal function tests
- Serum glucose levels
Which of the following statements about the use of aspirin and clopidogrel is true?
Which of the following statements about the use of aspirin and clopidogrel is true?
What is a key difference between oral and intravenous antiplatelet drugs?
What is a key difference between oral and intravenous antiplatelet drugs?
What should patients taking antiplatelet drugs do if they seek healthcare for other conditions?
What should patients taking antiplatelet drugs do if they seek healthcare for other conditions?
Which symptoms should be reported by patients using oral antiplatelet drugs?
Which symptoms should be reported by patients using oral antiplatelet drugs?
What potential risk is increased with the use of intravenous antiplatelet drugs compared to oral ones?
What potential risk is increased with the use of intravenous antiplatelet drugs compared to oral ones?
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Study Notes
Oral Antiplatelet Drugs
- Examples: aspirin, clopidogrel
- Mechanism of Action: Inhibit platelet aggregation in the arteries, preventing thrombus formation
- Aspirin and clopidogrel block different platelet activation pathways.
- Low-dose aspirin (80 mg/day) is typically used for antiplatelet effects.
Nursing Considerations for Oral Antiplatelet Drugs
- Assess history of intracranial hemorrhage, upper GI bleeding, peptic ulcer disease, or known bleeding tendencies.
- Monitor for and report increased bruising, petechiae, purpura, and apparent or occult bleeding.
- Do not administer concurrently with warfarin.
Intravenous Antiplatelet Drugs
- Examples: abciximab, eptifibatide, tirofiban
- Mechanism of Action: Block the final common pathway of platelet activation, making them more effective than oral antiplatelet drugs.
- Increased risk of bleeding compared to oral antiplatelet drugs.
Nursing Considerations for Intravenous Antiplatelet Drugs
- Determine history of bleeding disorders, intracranial hemorrhage, or recent trauma or surgery.
- Inquire about recent use of oral antiplatelet or anticoagulant drugs.
- Monitor CBC, including hemoglobin, hematocrit, and platelet count, and clotting studies.
- Monitor vital signs and ECG during therapy.
- Maintain separate IV lines for blood draws and administration of other drugs during infusion.
- Closely observe for and immediately report anaphylaxis or bleeding uncontrolled by pressure.
- Keep resuscitation equipment readily available.
- Maintain bedrest during infusion.
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