5 Questions
Which phase of the cell cycle is DNA damage most toxic for cytotoxic drugs?
S phase
Which normal tissues are major sites of acute toxicity for anticancer drugs?
Bone marrow, gastrointestinal tract, and hair follicles
What is the major form of resistance to anthracyclines and vinca alkaloids?
Multidrug resistance
What is the function of P-glycoprotein in tumor cells?
Acts as a drug efflux pump
What is the major limiting factor in the chemotherapy of cancer?
Lack of selective toxicity
Study Notes
Cell Cycle and Cytotoxic Drugs
- DNA damage is most toxic during the S phase of the cell cycle for cytotoxic drugs.
Acute Toxicity of Anticancer Drugs
- Major normal tissues affected by acute toxicity of anticancer drugs include bone marrow and the gastrointestinal epithelium.
Resistance to Chemotherapy
- The major form of resistance to anthracyclines and vinca alkaloids is the overexpression of P-glycoprotein.
Function of P-glycoprotein
- P-glycoprotein functions as a multidrug efflux pump in tumor cells, leading to chemotherapeutic resistance.
Limitations of Chemotherapy
- The major limiting factor in the chemotherapy of cancer is the development of drug resistance.
Test your knowledge about antineoplastic agents, their mechanisms of action, and resistance to cytotoxic drugs. Learn about how these drugs target DNA synthesis and disrupt mitosis in cancer cells.
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