Podcast
Questions and Answers
Which of the following statements about vancomycin is correct?
Which of the following statements about vancomycin is correct?
- It is primarily excreted through the hepatobiliary system.
- It is a narrow-spectrum antibiotic that targets only Gram-positive bacteria. (correct)
- It can penetrate the porins of Gram-negative organisms.
- It is active against methicillin-susceptible Staphylococcus aureus (MSSA).
What is the mechanism of action of glycopeptide antibiotics like vancomycin?
What is the mechanism of action of glycopeptide antibiotics like vancomycin?
- They inhibit bacterial DNA synthesis by inhibiting topoisomerase enzymes.
- They disrupt the bacterial cell membrane by forming pores.
- They inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit.
- They inhibit bacterial cell wall synthesis by binding to the D-alanine-D-alanine residues of peptidoglycan precursors. (correct)
Which of the following statements about the distribution of vancomycin is correct?
Which of the following statements about the distribution of vancomycin is correct?
- It is primarily distributed to the liver and has poor penetration into other tissues.
- It is widely distributed in the body, including the CSF, with CSF levels ranging from 7-30% of serum levels. (correct)
- It achieves high concentrations in the cerebrospinal fluid (CSF).
- It does not cross the blood-brain barrier and has poor penetration into the CSF.
Which of the following statements about the clinical uses of vancomycin is correct?
Which of the following statements about the clinical uses of vancomycin is correct?
Which of the following statements about the lipoglycopeptides (e.g., oritavancin, telavancin, dalbavancin) is correct?
Which of the following statements about the lipoglycopeptides (e.g., oritavancin, telavancin, dalbavancin) is correct?
Which of the following statements about the pharmacokinetics of vancomycin is correct?
Which of the following statements about the pharmacokinetics of vancomycin is correct?
What is the primary mechanism of action of vancomycin?
What is the primary mechanism of action of vancomycin?
Which antibiotic is used specifically for the treatment of Clostridium difficile infection?
Which antibiotic is used specifically for the treatment of Clostridium difficile infection?
Which adverse effect of vancomycin is associated with histamine release?
Which adverse effect of vancomycin is associated with histamine release?
Which antibiotic is active against vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA)?
Which antibiotic is active against vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA)?
What is the primary mechanism of action of fosfomycin?
What is the primary mechanism of action of fosfomycin?
Which antibiotic is used primarily for the treatment of tuberculosis?
Which antibiotic is used primarily for the treatment of tuberculosis?
Which antibiotic is only used topically due to its high nephrotoxicity when administered systemically?
Which antibiotic is only used topically due to its high nephrotoxicity when administered systemically?
Which antibiotic is a lipopeptide with activity against most gram-negative bacteria, including Acinetobacter spp. and Pseudomonas spp.?
Which antibiotic is a lipopeptide with activity against most gram-negative bacteria, including Acinetobacter spp. and Pseudomonas spp.?
Which antibiotic binds to the peptidoglycan pentapeptide chain and has a strict requirement for two alanines?
Which antibiotic binds to the peptidoglycan pentapeptide chain and has a strict requirement for two alanines?
Which administration method of vancomycin is associated with a lower risk of nephrotoxicity and ototoxicity compared to intermittent infusion?
Which administration method of vancomycin is associated with a lower risk of nephrotoxicity and ototoxicity compared to intermittent infusion?
Which antibiotic is a lipopeptide that acts on the bacterial membrane?
Which antibiotic is a lipopeptide that acts on the bacterial membrane?
For which type of bacteria is vancomycin bactericidal?
For which type of bacteria is vancomycin bactericidal?
Which antibiotic is primarily excreted by glomerular filtration?
Which antibiotic is primarily excreted by glomerular filtration?
What is the main clinical use of vancomycin?
What is the main clinical use of vancomycin?
Which antibiotic has a strict requirement for two alanines in its mechanism of action?
Which antibiotic has a strict requirement for two alanines in its mechanism of action?
Among the listed antibiotics, which one has activity against VRE (vancomycin-resistant enterococci)?
Among the listed antibiotics, which one has activity against VRE (vancomycin-resistant enterococci)?
What is the main target of fosfomycin's antibacterial activity?
What is the main target of fosfomycin's antibacterial activity?
Which antibiotic is known for its inability to penetrate the porins of Gram-negative organisms?
Which antibiotic is known for its inability to penetrate the porins of Gram-negative organisms?
For which type of organisms is vancomycin specifically active?
For which type of organisms is vancomycin specifically active?
What makes glycopeptides like vancomycin unable to penetrate the porins of Gram-negative organisms?
What makes glycopeptides like vancomycin unable to penetrate the porins of Gram-negative organisms?
Which of the following statements about vancomycin resistance is correct?
Which of the following statements about vancomycin resistance is correct?
Which of the following statements about daptomycin is incorrect?
Which of the following statements about daptomycin is incorrect?
What is the primary mechanism of action of fosfomycin?
What is the primary mechanism of action of fosfomycin?
Which of the following statements about cycloserine is correct?
Which of the following statements about cycloserine is correct?
Which of the following statements about vancomycin is correct?
Which of the following statements about vancomycin is correct?
