26 Questions
Match the drug with its cost per 10-day regimen:
Metronidazole 500 mg tablet = $22.00 Metronidazole 500 mg/5 mL suspension (Likmez™) = $490.00 Vancomycin 125 mg capsules = $680.00 Vancomycin 125 mg IV compounded for oral solution = $100.00 - $400.00
Match the drug with its primary regimen frequency:
Metronidazole 500 mg tablet = 500 mg TID Metronidazole 500 mg/5 mL suspension (Likmez™) = 500 mg TID Vancomycin 125 mg capsules = 125 mg QID Vancomycin 125 mg IV compounded for oral solution = 125 mg QID
Match the following steps in antimicrobial therapy with their descriptions:
Collect = Assess if the patient is infected Assess = Evaluate indication, effectiveness, safety, adherence Plan = Select empiric therapy using IESA and antibiogram Follow-Up/Monitoring = Assess therapeutic response and adjust based on culture/susceptibility data
Match the drug with its cost per dose:
Metronidazole 500 mg tablet = $0.73 Metronidazole 500 mg/5 mL suspension (Likmez™) = $3.27 Vancomycin 125 mg capsules = $17.00 Vancomycin 125 mg IV compounded for oral solution = $2.50 - $10.00
Match the drug with its primary usage type:
Metronidazole = Antibiotic Vancomycin = Antibiotic Fidaxomicin = Antibiotic
Match the components of IESA with their assessment criteria:
Indication = Assessment of site of infection and severity of illness Effectiveness = Evaluation based on killing type evidence Safety = Consideration of allergies, organ dysfunction, dose assessment, ADEs, drug interactions Adherence = Evaluation of dosage form, dosing interval, cost, duration of therapy
Match the types of diarrhea with their medical definitions:
Enterotoxigenic = Watery diarrhea Dysentery = Bloody diarrhea Gastroenteritis = Increased frequency of stools that are watery or loose Medical Definitions of Diarrhea = Increased frequency of stools > 3 per day with watery or loose consistency
Match the drug with its available form for pediatric use:
Fidaxomicin 200 mg tablet = Not specified for pediatric use Fidaxomicin 40 mg/mL suspension Pediatric use only = Pediatric use only Vancomycin 125 mg capsules = Not specified for pediatric use
Match the following abbreviations with their meanings:
PPCP = Pharmacist Patient Care Process OTC = Over The Counter GI = Gastrointestinal CDI = Clostridioides difficile infection
Match the following pathogens with their categories causing GI infections:
Viruses = most common Bacteria = Parasites =
Match the following statements with the correct data on GI infections:
Globally, cases of diarrhea annually = 1.7 billion Globally, deaths annually = 2 million Second leading cause of mortality in children < 5 years of age globally = Cases annually in the US with deaths = 179 million, 5000
Match the following symptoms with their condition related to GI infections:
Vomiting & Diarrhea = Significant Volume Depletion Dehydration & Abdominal Pain = Fever & Fatigue =
Match the following references with their publication details:
Molecular Pathology in Clinical Practice. 2015;707-734. = Roecker A et al. = Gastrointestinal Infections and Enterotoxigenic Poisonings Burd EM, Hinrichs BH. = Published date: May 19, 2015; DOI: 10.1007/978-3-319-19674-9_50 =
Match the following topics with their relevance to GI infections:
Approach for Selecting Antimicrobial Therapy Collect Is my patient infected? = Death?In the News… =
Match the treatment with the correct condition it is recommended for:
Fidaxomicin or vancomycin with tapered regimens or combination therapy (e.g., adding rifaximin) = Second recurrence of CDI Fecal microbiota transplantation = Multiple recurrences of CDI Bezlotoxumab 10 mg/kg given IV = Adjunctive treatment for CDI Vancomycin 500 mg PO QID PLUS Metronidazole 500mg IV q8h = Treatment for fulminant CDI
Match the medication with its description:
Bezlotoxumab (Zinplava®) = Monoclonal antibody to bind C.diff toxin B Fecal Transplants = Infusion of diluted feces from a healthy donor into the GI tract of a recipient Rebyota© - Fecal microbiota, live-jslm Suspension for rectal use = Type of fecal microbiota transplantation product Vowst™ - Fecal microbiota spores, live-brpk Oral capsule = Type of fecal microbiota transplantation product
Match the medication administration route with the correct medication:
IV administration = Metronidazole 500mg PO administration = Vancomycin 500 mg Rectal use = Rebyota© - Fecal microbiota, live-jslm Suspension
Match the guideline update with its content:
Heart failure warning = Bezlotoxumab (Zinplava®) Decreased recurrence = Based on MODIFY I and MODIFY II trials Donor selection requires rigorous screening = Fecal transplants Restores colonic flora = Fecal transplants
Match the treatment regimen with the correct scenario:
Adding rifaximin to fidaxomicin or vancomycin = Second recurrence of CDI Vancomycin 500 mg PO QID PLUS Metronidazole 500mg IV q8h = Fulminant CDI with ileus Fecal microbiota transplantation = Patients who have tried antibiotics for 3 CDI episodes Bezlotoxumab 10 mg/kg given IV once during standard care antibiotic administration = Adjunctive treatment in CDI
Match the publication with its details:
Clin Endosc. 2016;49(3):257-65 = Publication on fecal microbiota transplantation Ther Clin Risk Manag. 2008;4(5):949-64 = Publication on Clostridium difficile infection guidelines
Match the following with their respective meaning: Indication, Effectiveness, Safety, Adherence (IESA)
Indication = Determining if the treatment is appropriate for the diagnosed condition Effectiveness = Evaluating how well the treatment works in addressing the condition Safety = Assessing the potential risks and side effects of the treatment Adherence = Ensuring that the patient follows the prescribed treatment regimen
Match the symptoms with their associated gastrointestinal infections: Diarrhea Watery-Secretory Bloody-Dysentery Abdominal pain
Diarrhea Watery-Secretory = Commonly seen in viral gastroenteritis or cholera Bloody-Dysentery = Indicative of bacterial infections like Shigella or EHEC Abdominal pain = Can be a symptom of various gastrointestinal infections Nausea Vomiting = Associated with food poisoning or viral infections
Match the following lab findings with their significance: Elevated SCr and BUN, â urine output á WBC Stool studies for dysentery
Elevated SCr and BUN = Indicative of dehydration or kidney dysfunction â urine output á WBC = Suggestive of an inflammatory process or infection Stool studies for dysentery = Used to identify specific pathogens causing dysentery Evaluate for Campylobacter, Shigella, Salmonella and EHEC (0157:H7 strain) = Testing for common bacterial causes of gastrointestinal infections
Match the physical exam findings with their possible implications: Dry mucous membranes Abdominal tenderness Hyperactive or hypoactive bowel sounds
Dry mucous membranes = Sign of dehydration in a patient Abdominal tenderness = Can indicate inflammation or infection in the abdomen Hyperactive or hypoactive bowel sounds = Abnormal bowel motility often seen in gastrointestinal issues Labs Elevated SCr and BUN, â urine output á WBC = Correlates with dehydration and possible infection
Match the terms with their meanings: BP=Blood Pressure HR=Heart Rate RR=Respiratory Rate BUM=Blood Urine Nitrogen
BP=Blood Pressure = Measure of the force exerted by blood against the walls of blood vessels HR=Heart Rate = Number of heartbeats per minute, indicating cardiac function RR=Respiratory Rate = Number of breaths taken per minute, reflecting lung function BUM=Blood Urine Nitrogen = Indicator of kidney function and hydration status
Match the signs/symptoms with their associated conditions: Abdominal cramps Fever and chills Elevated CRP
Abdominal cramps = Common in various gastrointestinal infections and food poisoning cases Fever and chills = Typical systemic response to infections like bacterial gastroenteritis Elevated CRP = Indicates inflammation in the body, often seen in infectious processes Dry mucous membranes Abdominal tenderness Hyperactive or hypoactive bowel sounds = Physical exam findings suggestive of gastrointestinal issues
Test your knowledge on assessing indication, effectiveness, safety, and adherence of antimicrobial therapy, selecting empiric therapy based on IESA and antibiogram, and monitoring therapeutic response and re-evaluating based on culture and susceptibility data.
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