Antimicrobial Therapy Assessment Quiz

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Match the drug with its cost per 10-day regimen:

Metronidazole 500 mg tablet = $22.00 Metronidazole 500 mg/5 mL suspension (Likmez™) = $490.00 Vancomycin 125 mg capsules = $680.00 Vancomycin 125 mg IV compounded for oral solution = $100.00 - $400.00

Match the drug with its primary regimen frequency:

Metronidazole 500 mg tablet = 500 mg TID Metronidazole 500 mg/5 mL suspension (Likmez™) = 500 mg TID Vancomycin 125 mg capsules = 125 mg QID Vancomycin 125 mg IV compounded for oral solution = 125 mg QID

Match the following steps in antimicrobial therapy with their descriptions:

Collect = Assess if the patient is infected Assess = Evaluate indication, effectiveness, safety, adherence Plan = Select empiric therapy using IESA and antibiogram Follow-Up/Monitoring = Assess therapeutic response and adjust based on culture/susceptibility data

Match the drug with its cost per dose:

Metronidazole 500 mg tablet = $0.73 Metronidazole 500 mg/5 mL suspension (Likmez™) = $3.27 Vancomycin 125 mg capsules = $17.00 Vancomycin 125 mg IV compounded for oral solution = $2.50 - $10.00 Signup and view all the answers

Match the drug with its primary usage type:

Metronidazole = Antibiotic Vancomycin = Antibiotic Fidaxomicin = Antibiotic Signup and view all the answers

Match the components of IESA with their assessment criteria:

Indication = Assessment of site of infection and severity of illness Effectiveness = Evaluation based on killing type evidence Safety = Consideration of allergies, organ dysfunction, dose assessment, ADEs, drug interactions Adherence = Evaluation of dosage form, dosing interval, cost, duration of therapy Signup and view all the answers

Match the types of diarrhea with their medical definitions:

Enterotoxigenic = Watery diarrhea Dysentery = Bloody diarrhea Gastroenteritis = Increased frequency of stools that are watery or loose Medical Definitions of Diarrhea = Increased frequency of stools > 3 per day with watery or loose consistency Signup and view all the answers

Match the drug with its available form for pediatric use:

Fidaxomicin 200 mg tablet = Not specified for pediatric use Fidaxomicin 40 mg/mL suspension Pediatric use only = Pediatric use only Vancomycin 125 mg capsules = Not specified for pediatric use Signup and view all the answers

Match the following abbreviations with their meanings:

PPCP = Pharmacist Patient Care Process OTC = Over The Counter GI = Gastrointestinal CDI = Clostridioides difficile infection Signup and view all the answers

Match the following pathogens with their categories causing GI infections:

Viruses = most common Bacteria = Parasites = Signup and view all the answers

Match the following statements with the correct data on GI infections:

Globally, cases of diarrhea annually = 1.7 billion Globally, deaths annually = 2 million Second leading cause of mortality in children < 5 years of age globally = Cases annually in the US with deaths = 179 million, 5000 Signup and view all the answers

Match the following symptoms with their condition related to GI infections:

Vomiting & Diarrhea = Significant Volume Depletion Dehydration & Abdominal Pain = Fever & Fatigue = Signup and view all the answers

Match the following references with their publication details:

Molecular Pathology in Clinical Practice. 2015;707-734. = Roecker A et al. = Gastrointestinal Infections and Enterotoxigenic Poisonings Burd EM, Hinrichs BH. = Published date: May 19, 2015; DOI: 10.1007/978-3-319-19674-9_50 = Signup and view all the answers

Match the following topics with their relevance to GI infections:

Approach for Selecting Antimicrobial Therapy Collect Is my patient infected? = Death?In the News… = Signup and view all the answers

Match the treatment with the correct condition it is recommended for:

Fidaxomicin or vancomycin with tapered regimens or combination therapy (e.g., adding rifaximin) = Second recurrence of CDI Fecal microbiota transplantation = Multiple recurrences of CDI Bezlotoxumab 10 mg/kg given IV = Adjunctive treatment for CDI Vancomycin 500 mg PO QID PLUS Metronidazole 500mg IV q8h = Treatment for fulminant CDI Signup and view all the answers

Match the medication with its description:

Bezlotoxumab (Zinplava®) = Monoclonal antibody to bind C.diff toxin B Fecal Transplants = Infusion of diluted feces from a healthy donor into the GI tract of a recipient Rebyota© - Fecal microbiota, live-jslm Suspension for rectal use = Type of fecal microbiota transplantation product Vowst™ - Fecal microbiota spores, live-brpk Oral capsule = Type of fecal microbiota transplantation product Signup and view all the answers

Match the medication administration route with the correct medication:

IV administration = Metronidazole 500mg PO administration = Vancomycin 500 mg Rectal use = Rebyota© - Fecal microbiota, live-jslm Suspension Signup and view all the answers

Match the guideline update with its content:

Heart failure warning = Bezlotoxumab (Zinplava®) Decreased recurrence = Based on MODIFY I and MODIFY II trials Donor selection requires rigorous screening = Fecal transplants Restores colonic flora = Fecal transplants Signup and view all the answers

Match the treatment regimen with the correct scenario:

Adding rifaximin to fidaxomicin or vancomycin = Second recurrence of CDI Vancomycin 500 mg PO QID PLUS Metronidazole 500mg IV q8h = Fulminant CDI with ileus Fecal microbiota transplantation = Patients who have tried antibiotics for 3 CDI episodes Bezlotoxumab 10 mg/kg given IV once during standard care antibiotic administration = Adjunctive treatment in CDI Signup and view all the answers

Match the publication with its details:

Clin Endosc. 2016;49(3):257-65 = Publication on fecal microbiota transplantation Ther Clin Risk Manag. 2008;4(5):949-64 = Publication on Clostridium difficile infection guidelines Signup and view all the answers

Match the following with their respective meaning: Indication, Effectiveness, Safety, Adherence (IESA)

Indication = Determining if the treatment is appropriate for the diagnosed condition Effectiveness = Evaluating how well the treatment works in addressing the condition Safety = Assessing the potential risks and side effects of the treatment Adherence = Ensuring that the patient follows the prescribed treatment regimen Signup and view all the answers

Match the symptoms with their associated gastrointestinal infections: Diarrhea Watery-Secretory Bloody-Dysentery Abdominal pain

Diarrhea Watery-Secretory = Commonly seen in viral gastroenteritis or cholera Bloody-Dysentery = Indicative of bacterial infections like Shigella or EHEC Abdominal pain = Can be a symptom of various gastrointestinal infections Nausea Vomiting = Associated with food poisoning or viral infections Signup and view all the answers

Match the following lab findings with their significance: Elevated SCr and BUN, â urine output á WBC Stool studies for dysentery

Elevated SCr and BUN = Indicative of dehydration or kidney dysfunction â urine output á WBC = Suggestive of an inflammatory process or infection Stool studies for dysentery = Used to identify specific pathogens causing dysentery Evaluate for Campylobacter, Shigella, Salmonella and EHEC (0157:H7 strain) = Testing for common bacterial causes of gastrointestinal infections Signup and view all the answers

Match the physical exam findings with their possible implications: Dry mucous membranes Abdominal tenderness Hyperactive or hypoactive bowel sounds

Dry mucous membranes = Sign of dehydration in a patient Abdominal tenderness = Can indicate inflammation or infection in the abdomen Hyperactive or hypoactive bowel sounds = Abnormal bowel motility often seen in gastrointestinal issues Labs Elevated SCr and BUN, â urine output á WBC = Correlates with dehydration and possible infection Signup and view all the answers

Match the terms with their meanings: BP=Blood Pressure HR=Heart Rate RR=Respiratory Rate BUM=Blood Urine Nitrogen

BP=Blood Pressure = Measure of the force exerted by blood against the walls of blood vessels HR=Heart Rate = Number of heartbeats per minute, indicating cardiac function RR=Respiratory Rate = Number of breaths taken per minute, reflecting lung function BUM=Blood Urine Nitrogen = Indicator of kidney function and hydration status Signup and view all the answers

Match the signs/symptoms with their associated conditions: Abdominal cramps Fever and chills Elevated CRP

Abdominal cramps = Common in various gastrointestinal infections and food poisoning cases Fever and chills = Typical systemic response to infections like bacterial gastroenteritis Elevated CRP = Indicates inflammation in the body, often seen in infectious processes Dry mucous membranes Abdominal tenderness Hyperactive or hypoactive bowel sounds = Physical exam findings suggestive of gastrointestinal issues Signup and view all the answers