Antimicrobial Spectrum Quiz

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Questions and Answers

What is the main goal when determining the dosage of medication?

  • To reduce therapeutic drug levels
  • To maximize side effects
  • To induce superinfections
  • To achieve optimal therapeutic drug levels without causing significant toxicity (correct)

Why is it important to carefully determine the dosage of medication?

  • To eliminate the need for therapeutic drug levels
  • To prevent superinfections
  • To achieve optimum therapeutic drug levels while minimizing side effects (correct)
  • To increase the risk of side effects

Which factor influences the dose of medication in children but not in adults and children 12 years and older?

  • Dosage interval
  • Drug metabolism rate
  • Age of the patient
  • Weight of the patient (correct)

What are superinfections that can develop as a result of antimicrobial usage?

<p>Yeast infections (D)</p> Signup and view all the answers

What is the primary consideration when selecting the best dose and dosage interval?

<p>Drug class (D)</p> Signup and view all the answers

Why do potential serious side effects sometimes occur despite efforts to optimize dosing?

<p>As a result of drug class variability in side effects (C)</p> Signup and view all the answers

What is the primary advantage of using a narrow-spectrum antimicrobial when the pathogen causing an infection has been identified?

<p>It minimizes damage to the normal microbiota. (B)</p> Signup and view all the answers

In what scenario are broad-spectrum antimicrobials frequently used as empiric therapy?

<p>To cover a wide range of potential pathogens while awaiting pathogen identification. (B)</p> Signup and view all the answers

What is the purpose of using broad-spectrum antimicrobials for mixed infections with multiple bacterial species?

<p>To cover a wide range of potential pathogens. (D)</p> Signup and view all the answers

How does a superinfection develop when using broad-spectrum antimicrobials?

<p>When another pathogen resistant to the antimicrobial proliferates due to microbiota damage. (A)</p> Signup and view all the answers

Why might broad-spectrum antimicrobials be selected to treat an infection after a narrow-spectrum drug has failed?

<p>To cover a wide range of potential pathogens effectively. (C)</p> Signup and view all the answers

What is the main risk associated with using broad-spectrum antimicrobials?

<p>Increasing the risk of superinfection by damaging normal microbiota. (D)</p> Signup and view all the answers

What effect do individually the two drugs have on bacterial growth?

<p>Bacteriostatic (A)</p> Signup and view all the answers

What is the result of combining the two drugs in terms of their effect on bacteria?

<p>Synergistic (A)</p> Signup and view all the answers

What do antagonistic drug interactions produce?

<p>Harmful effects (B)</p> Signup and view all the answers

Where can antagonism occur?

<p>Between antimicrobials or antimicrobials and non-antimicrobials (D)</p> Signup and view all the answers

How can the absorption of some anti-bacterials be negatively impacted by antacids?

<p>Increased pH of the stomach (D)</p> Signup and view all the answers

What negative impact can antagonistic drug interactions have on drug activity?

<p>Loss of drug activity (D)</p> Signup and view all the answers

Which patient population may experience increased drug levels that lead to toxicity due to reduced drug metabolism or clearance?

<p>Patients with a history of kidney dysfunction (C)</p> Signup and view all the answers

What does the half-life of a drug refer to?

<p>The rate at which 50% of a drug is eliminated from the plasma (B)</p> Signup and view all the answers

For drugs with a short half-life, how often must they typically be administered?

<p>Multiple times a day (D)</p> Signup and view all the answers

Why might a longer half-life be a concern for drugs with serious side effects?

<p>Because drug levels may remain toxic for a longer time (A)</p> Signup and view all the answers

What is the key difference between dose-dependent drugs and time-dependent drugs?

<p>Dose-dependent drugs require high levels for a long period (C)</p> Signup and view all the answers

Why is the route of administration an important consideration for drug therapy?

<p>It impacts how quickly and effectively the drug reaches the bloodstream (C)</p> Signup and view all the answers

Why are orally administered drugs generally preferred for patients?

<p>Patients can conveniently take them at home. (C)</p> Signup and view all the answers

In what situation would administration of a drug by a parenteral route be preferred?

<p>When the drug is not absorbed in the gastrointestinal tract. (C)</p> Signup and view all the answers

Which type of drugs are available as topical preparations for superficial skin infections?

<p>Antifungals like bacitracin and polymyxin. (A)</p> Signup and view all the answers

Which drug combination provides a synergistic interaction for the treatment of infections?

<p>Trimethoprim and sulfamethoxazole (Bactrim). (C)</p> Signup and view all the answers

What is a significant advantage of intravenous administration of most drugs?

<p>Rapid and higher plasma levels than oral or intramuscular administration. (A)</p> Signup and view all the answers

When might patients be unable to initially take oral medications?

<p>Due to gastrointestinal absorption issues like vomiting. (C)</p> Signup and view all the answers

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