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Antimicrobial Chemotherapy and Drug Resistance

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Questions and Answers

What is meant by drug resistance in the context of antimicrobial chemotherapy?

Development of new antibiotics that are more effective.
A reduction in the side effects of the drug.
Unresponsiveness of organisms to the administered drug. (correct)
An increase in the effectiveness of the drug over time.

Which mechanism contributes to the development of drug resistance?

Improved drug absorption by the bacteria.
Increased interaction with host cells.
Production of enzymes that destroy the drug. (correct)
Enhanced immune response from the host.

What non-genetic origin factor can lead to drug resistance in bacteria?

The presence of developmentally inactive organisms. (correct)
Natural selection in diverse environments.
Mutations in chromosomal DNA.
Incorporation of plasmids with resistance genes.

Which of the following is NOT a complication associated with antimicrobial chemotherapy?

<p>Infections that are more easily treated. (D)</p> Signup and view all the answers

What does an alteration of the receptor target imply in drug resistance?

<p>The drug can no longer bind effectively to its target. (C)</p> Signup and view all the answers

Flashcards

Drug resistance

The inability of a microorganism to be affected by an antibiotic, rendering the drug ineffective.

Mechanism of drug resistance

The ways a microorganism can avoid or become unaffected by an antibiotic.

Genetic drug resistance

Drug resistance mechanisms that originate from changes in a microbe's genes.

Non-genetic drug resistance

Drug resistance that isn't caused by changes in a microbe's genetic makeup.

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Efflux Pump

A protein that actively moves antibiotics out of a bacterial cell, reducing their effectiveness.