Antimicrobial Chemotherapy and Drug Resistance
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Questions and Answers

What is meant by drug resistance in the context of antimicrobial chemotherapy?

  • Development of new antibiotics that are more effective.
  • A reduction in the side effects of the drug.
  • Unresponsiveness of organisms to the administered drug. (correct)
  • An increase in the effectiveness of the drug over time.

    • Which mechanism contributes to the development of drug resistance?

  • Improved drug absorption by the bacteria.
  • Increased interaction with host cells.
  • Production of enzymes that destroy the drug. (correct)
  • Enhanced immune response from the host.

    • What non-genetic origin factor can lead to drug resistance in bacteria?

  • The presence of developmentally inactive organisms. (correct)
  • Natural selection in diverse environments.
  • Mutations in chromosomal DNA.
  • Incorporation of plasmids with resistance genes.

    • Which of the following is NOT a complication associated with antimicrobial chemotherapy?

    <p>Infections that are more easily treated. (D)</p> Signup and view all the answers

    What does an alteration of the receptor target imply in drug resistance?

    <p>The drug can no longer bind effectively to its target. (C)</p> Signup and view all the answers

    Flashcards

    Drug resistance

    The inability of a microorganism to be affected by an antibiotic, rendering the drug ineffective.

    Mechanism of drug resistance

    The ways a microorganism can avoid or become unaffected by an antibiotic.

    Genetic drug resistance

    Drug resistance mechanisms that originate from changes in a microbe's genes.

    Non-genetic drug resistance

    Drug resistance that isn't caused by changes in a microbe's genetic makeup.

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    Efflux Pump

    A protein that actively moves antibiotics out of a bacterial cell, reducing their effectiveness.

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