12 Questions
What is the primary mechanism of action of antimetabolites?
Inhibition of DNA synthesis
When is the maximal cytotoxic effect of antimetabolites observed?
S phase
How can some adverse effects of antimetabolites be prevented or reversed?
Administering leucovorin
What is a notable adverse effect known as 'Hand-foot syndrome' associated with antimetabolites?
Palmar-plantar erythrodysesthesia
What should be done to prevent conjunctivitis when administering high doses of antimetabolites?
Administer steroid eye drops
What parameter needs adjustment in patients with renal impairment when using antimetabolites?
Reduce dose of another drug
Which enzyme does methotrexate inhibit?
Dihydrofolate reductase
What is the role of folic acid in cell replication?
It donates one-carbon units essential for DNA synthesis
How can the inhibition of dihydrofolate reductase by methotrexate be reversed?
Leucovorin administration
Which drug is used to replenish the folate pool when methotrexate inhibits dihydrofolate reductase?
Leucovorin
What is the main dietary source of folic acid?
Vegetables
What is the mechanism of action of antifolate agents like pemetrexed and pralatrexate?
Inhibition of dihydrofolate reductase
Learn about antimetabolites, a class of drugs that interfere with enzymes necessary for DNA synthesis by competing with normal nucleotide precursors. Discover how they exert their cytotoxic effects in the S phase of the cell cycle.
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