Antigen Receptor Diversity in Lymphocytes Quiz
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Questions and Answers

Which mechanisms generate junctional diversity in the diversity of antigen receptors?

  • V, D, and J gene segments
  • Germline genes and N regions
  • Hairpin loops and P-nucleotides
  • Exonucleases and TdT enzyme (correct)

    • What limits the combinatorial diversity of antigen receptors?

  • Exonucleases and TdT enzyme
  • Hairpin loops and P-nucleotides
  • Number of available V, D, and J gene segments (correct)
  • Germline genes and N regions

    • What is the function of terminal deoxyribonucleotidyl transferase (TdT) enzyme in the generation of junctional diversity?

  • Forms hairpin loops in the DNA
  • Removes nucleotides from V, D, and J gene segments
  • Catalyzes the random addition of nucleotides (correct)
  • Introduces P-nucleotides at the sites of recombination

    • Which of the following is true about the nucleotide sequence at the site of V(D)J recombination in antibody or TCR genes?

    <p>It differs from the sequence at the V(D)J site of antibody or TCR molecules made by every other clone.</p> Signup and view all the answers

    What is the purpose of junctional diversity in the immune system?

    <p>To generate tremendous diversity in the antigen-recognizing portions of antibodies and TCRs.</p> Signup and view all the answers

    How can the uniqueness of CDR3 sequences in lymphocyte clones be used in medical diagnosis?

    <p>To distinguish neoplastic and reactive proliferations of B and T lymphocytes.</p> Signup and view all the answers

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