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Questions and Answers
Which mechanisms generate junctional diversity in the diversity of antigen receptors?
Which mechanisms generate junctional diversity in the diversity of antigen receptors?
- V, D, and J gene segments
- Germline genes and N regions
- Hairpin loops and P-nucleotides
- Exonucleases and TdT enzyme (correct)
What limits the combinatorial diversity of antigen receptors?
What limits the combinatorial diversity of antigen receptors?
- Exonucleases and TdT enzyme
- Hairpin loops and P-nucleotides
- Number of available V, D, and J gene segments (correct)
- Germline genes and N regions
What is the function of terminal deoxyribonucleotidyl transferase (TdT) enzyme in the generation of junctional diversity?
What is the function of terminal deoxyribonucleotidyl transferase (TdT) enzyme in the generation of junctional diversity?
- Forms hairpin loops in the DNA
- Removes nucleotides from V, D, and J gene segments
- Catalyzes the random addition of nucleotides (correct)
- Introduces P-nucleotides at the sites of recombination
Which of the following is true about the nucleotide sequence at the site of V(D)J recombination in antibody or TCR genes?
Which of the following is true about the nucleotide sequence at the site of V(D)J recombination in antibody or TCR genes?
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What is the purpose of junctional diversity in the immune system?
What is the purpose of junctional diversity in the immune system?
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How can the uniqueness of CDR3 sequences in lymphocyte clones be used in medical diagnosis?
How can the uniqueness of CDR3 sequences in lymphocyte clones be used in medical diagnosis?
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