Antigen-Presenting Cells and MHC Expression Quiz

Which cell type expresses class II MHC constitutively and increases expression with maturation and by IFN-gamma?

What principal function is associated with dendritic cells in the context of antigen presentation?

Which cell type plays a role in the maturation and selection of T cells in the thymus?

Which cell type can present class I MHC–associated peptides to CD8+ T cells?

What is the principal function of macrophages in the effector phase of cell-mediated immune responses?

What induces the expression of class 2 MHC in macrophages?

What is the effect of TLR ligands on the expression of co-stimulators in macrophages?

In B lymphocytes, what induces the expression of class 2 MHC?

What is the principal function of B lymphocytes in humoral immune responses?

What is the physiologic role of MHC molecules?

What kind of genes are present in the MHC that code for proteins involved in antigen presentation?

What do MHC molecules explain?

What are MHC genes also known as in humans?

Antigen Presentation and MHC Molecules

Dendritic cells express class II MHC constitutively, and its expression increases with maturation and in response to IFN-gamma.
Dendritic cells are responsible for processing and presenting antigens to T-cells, activating an immune response.

Thymic T Cell Maturation

Thymic epithelial cells play a crucial role in the maturation and selection of T cells in the thymus.

Antigen Presentation and T Cells

Class I MHC-associated peptides are presented to CD8+ T cells by antigen-presenting cells (APCs).
CD8+ T cells recognize and respond to these peptides, leading to cell-mediated immune responses.

Macrophages in Cell-Mediated Immunity

Macrophages play a key role in the effector phase of cell-mediated immune responses, where they phagocytose and eliminate pathogens.
IFN-gamma induces the expression of class II MHC in macrophages, enhancing their antigen-presenting capacity.
TLR ligands stimulate the expression of co-stimulatory molecules in macrophages, amplifying immune responses.

B Lymphocytes and Humoral Immunity

IFN-gamma induces the expression of class II MHC in B lymphocytes, enabling them to present antigens to T cells.
B lymphocytes are central to humoral immune responses, producing antibodies that recognize and eliminate pathogens.

MHC Molecules and Antigen Presentation

MHC molecules are responsible for presenting antigens to T cells, initiating immune responses.
The MHC complex contains genes that code for proteins involved in antigen presentation, including class I and class II MHC molecules.
MHC molecules explain the genetic basis of transplantation rejection and autoimmune diseases.
In humans, MHC genes are also known as human leukocyte antigens (HLA).

Test your knowledge on the properties and roles of antigen-presenting cells expressing class II major histocompatibility complex (MHC) in initiating immune responses and interacting with CD4+ helper T cells.