Antifungal Drugs Quiz

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Questions and Answers

Which antifungal is primarily used for systemic infections?

  • Nystatin
  • Terbinafine
  • Clotrimazole
  • Amphotericin B (correct)

What type of infections is Nystatin mainly indicated for?

  • Autoimmune diseases
  • Localized infections (correct)
  • Systemic infections
  • Dermatophytic infections

Which antifungal can also serve as an antibiotic?

  • Metronidazole (correct)
  • Terbinafine
  • Itraconazole
  • Fluconazole

What is a common use for Terbinafine?

<p>Management of athlete’s foot (B)</p> Signup and view all the answers

Which patient group is at higher risk when using systemic antifungals?

<p>Patients with chronic diseases or immunocompromised conditions (D)</p> Signup and view all the answers

Which medication is primarily used for the prophylaxis of Influenza A in susceptible groups?

<p>Amantadine (B)</p> Signup and view all the answers

What is the mechanism of action of neuraminidase inhibitors such as Oseltamivir?

<p>Prevention of newly formed viruses from being released (B)</p> Signup and view all the answers

Which drug is indicated for the treatment of herpes simplex and herpes zoster?

<p>Famciclovir (A)</p> Signup and view all the answers

What is the major advantage of Famciclovir over Acyclovir in terms of dosing?

<p>Less frequent dosing (C)</p> Signup and view all the answers

Which medication is known for its application in treating cytomegalovirus retinitis in immunocompromised patients?

<p>Ganciclovir (A)</p> Signup and view all the answers

Which side effect is specifically associated with the inhalation use of Relenza?

<p>Bronchospasm (D)</p> Signup and view all the answers

What key feature distinguishes nucleoside analogs like Acyclovir from non-nucleoside reverse transcriptase inhibitors?

<p>Substituting for thymidine to stop viral replication (C)</p> Signup and view all the answers

What type of patients require dose adjustments for Amantadine due to renal or hepatic issues?

<p>Elderly or immunocompromised individuals (A)</p> Signup and view all the answers

What is a common symptom experienced by females infected with Trichomonas vaginalis?

<p>Foul-smelling vaginal discharge (C)</p> Signup and view all the answers

Which drug is indicated for the treatment of both Trichomonas infection and E. histolytica?

<p>Metronidazole (C)</p> Signup and view all the answers

What is the recommended dosage of Metronidazole for treating Trichomoniasis?

<p>2 g as a single dose or 250 mg TID for 1 week (D)</p> Signup and view all the answers

What significant interaction should be avoided while taking Metronidazole?

<p>Alcohol (A)</p> Signup and view all the answers

Which gastrointestinal infection is NOT treated by Paramomycin?

<p>Liver abscess from E. histolytica (D)</p> Signup and view all the answers

What is the primary mechanism of action for non-nucleoside reverse transcriptase inhibitors (RTIs)?

<p>Inhibition of reverse transcriptase enzyme (D)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with efavirenz (Sustiva)?

<p>Psychiatric symptoms (B)</p> Signup and view all the answers

Which drug serves a unique purpose in treating both HIV and chronic hepatitis B when evidence of Hep B replication is present?

<p>Lamivudine (A)</p> Signup and view all the answers

What type of medications are commonly used in combination to effectively treat HIV?

<p>Three or more antivirals from different classes (B)</p> Signup and view all the answers

What is a primary side effect of HIV medications such as Combivir?

<p>Hepatotoxicity (B)</p> Signup and view all the answers

What is a notable feature of the adverse effects of Nevirapine (Viramune)?

<p>Renal damage (D)</p> Signup and view all the answers

Which substance is an example of a protease inhibitor used in HIV treatment?

<p>Nelfinavir (B)</p> Signup and view all the answers

What is the mechanism of action (MOA) of Mebendazole?

<p>Inhibits larval development by blocking glucose uptake (C)</p> Signup and view all the answers

Which of the following is a recommended precaution for preventing worm infections?

<p>Careful hand washing (C)</p> Signup and view all the answers

Which of the following is a characteristic of combination therapy for HIV?

<p>Includes at least three different antiviral medications (A)</p> Signup and view all the answers

Which drug is known to inhibit CYP 3A4 and is a non-nucleoside RTI?

<p>Delavirdine (D)</p> Signup and view all the answers

What adverse effect can Pyrvinium Pamoate cause?

<p>Bright red stool staining (A)</p> Signup and view all the answers

Which drug is indicated for both roundworms and pinworms?

<p>Pyrantel Pamoate (C)</p> Signup and view all the answers

What type of infections are anthelmintics primarily used to treat?

<p>Parasitic worm infections (A)</p> Signup and view all the answers

What condition is characterized by high fevers and chills due to a protozoal infection?

<p>Malaria (C)</p> Signup and view all the answers

What is a common side effect of antimalarial drugs?

<p>Nausea and vomiting (C)</p> Signup and view all the answers

What is the desired outcome when treating worm infections?

<p>Prevention of re-infections (A)</p> Signup and view all the answers

Which of the following drugs is known for its cholinesterase effects causing neuromuscular blockade?

<p>Pyrantel Pamoate (A)</p> Signup and view all the answers

What is the mechanism of action of the antifungal treatment mentioned?

<p>Interferes with cell membrane sterols (A)</p> Signup and view all the answers

Which of the following is an indication for the use of Amantadine?

<p>Influenza A infection (C)</p> Signup and view all the answers

What is a common adverse effect associated with high oral doses of the antifungal medication?

<p>GI intolerance (A)</p> Signup and view all the answers

Which formulation of antifungal medication is available as a topical cream?

<p>Topical cream/ointment (A)</p> Signup and view all the answers

What is the preferred dosage form of Oseltamivir?

<p>Capsules (D)</p> Signup and view all the answers

Which of the following is NOT an antiviral drug?

<p>Sindoxavir (D)</p> Signup and view all the answers

What instruction is important for patients taking the oral suspension of the antifungal medication?

<p>Swish and swallow it (A)</p> Signup and view all the answers

Which symptom is most commonly associated with Influenza?

<p>Sinus pain (D)</p> Signup and view all the answers

What type of infections does Ribavirin primarily treat?

<p>Respiratory Syncytial Virus (RSV) (A)</p> Signup and view all the answers

Which of the following is a common adverse effect of oral antivirals for HIV treatment?

<p>Hepatotoxicity (B)</p> Signup and view all the answers

What is the primary role of viruses in the context of diseases?

<p>To reproduce only inside living cells (B)</p> Signup and view all the answers

Which antiviral drug is administered via inhalation powder?

<p>Zanamivir (D)</p> Signup and view all the answers

What is the recommended action if a patient experiences GI intolerance after taking a higher dose of an antifungal?

<p>Report to a healthcare provider (B)</p> Signup and view all the answers

Which molecule is crucial for maintaining cell membrane stability that antifungal treatments target?

<p>Sterols (D)</p> Signup and view all the answers

Flashcards

Antifungal Drugs

Medicines used to treat fungal infections, either localized (on the skin, nails, etc.) or systemic (throughout the body).

Local Antifungal Drugs

Antifungal medications applied directly to the affected area, like skin or vagina.

Systemic Antifungal Drugs

Antifungal medicines that travel throughout the body to fight widespread infections.

Common Antifungal Indications

Conditions like athlete's foot, vaginal yeast infections, and oral thrush that these antifungal drugs treat.

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Antifungal Risk Factors

Certain medical conditions, such as diabetes or weakened immune systems, can increase the risk from systemic antifungal use.

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Amantadine (Symmetrel)

A medication used for prophylaxis against influenza A in high-risk groups and to lessen symptoms during active infections.

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Neuraminidase Inhibitors

A class of antiviral drugs that prevent the release of new viral particles from infected cells, effectively stopping the spread of the virus.

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Oseltamivir (Tamiflu) AND Zanamivir (Relenza)

Two common neuraminidase inhibitors used to treat acute, uncomplicated influenza in adults and as prophylaxis during outbreaks.

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Acyclovir (Zovirax)

A nucleoside antiviral drug used to treat herpes simplex and herpes zoster infections.

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Famciclovir (Famvir)

A nucleoside antiviral drug similar to acyclovir, but with less frequent dosing, used for herpes zoster and simplex infections.

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Valacyclovir (Valtrex)

A nucleoside antiviral drug similar to famciclovir, but with a specific focus on treating genital herpes.

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Ganciclovir (Cytovene)

A nucleoside antiviral drug used to treat cytomegalovirus (CMV) retinitis in immunocompromised patients.

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Ribavirin (Ibayrr)

A nucleoside antiviral drug used in combination therapy for Hepatitis C.

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Trichomoniasis

A sexually transmitted infection caused by the protozoan Trichomonas vaginalis, affecting both males and females. In males, it can cause urethritis, while in females it can manifest with vaginal discharge, itching, and spotting.

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Metronidazole (Flagyl)

An antiprotozoal drug effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia. Also used as a bactericidal agent against anaerobic bacteria.

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Metronidazole Side Effects

Common side effects include nausea, anorexia, metallic taste, dizziness, vertigo, and skin rashes. Rarely, neuropathy can occur.

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Metronidazole and Alcohol

Metronidazole interacts with alcohol, causing a disulfiram reaction characterized by nausea, flushing, headache, and abdominal cramps. Avoid alcohol for 48 hours after the last dose.

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Chloroquine (Aralen)

An antimalarial drug also effective for treating amebic infections of the intestines and liver caused by Entamoeba histolytica.

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Non-Nucleoside RTIs

A class of antiviral drugs that inhibit the HIV reverse transcriptase enzyme, blocking viral DNA synthesis.

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Terbinafine indications

Fungal infections of skin, hair, and nails.

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Terbinafine MOA

Interferes with cell membrane sterols (important for membrane stability).

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Efavirenz (Sustiva)

A non-nucleoside reverse transcriptase inhibitor (NNRTI) commonly used in combination therapy for HIV.

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Nevirapine (Viramune)

A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination HIV therapy, known for potential renal damage.

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Oral Terbinafine side effects

Gastrointestinal issues (nausea, vomiting, diarrhea, abdominal pain), skin rash, pruritis, potentially hepatotoxicity.

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Nucleoside Analogue RTIs

A class of antiviral drugs that resemble the building blocks of DNA, interfering with HIV's reverse transcriptase enzyme and halting viral replication.

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Influenza antiviral

A medication that fights influenza viruses.

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Zidovudine (Retrovir) (AZT)

A nucleoside analogue reverse transcriptase inhibitor (NRTI) commonly used in HIV therapy, available as oral tablets, capsules, and injection.

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Amantadine indication

Antiviral (Influenza A) or Parkinson's Disease treatment.

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Oseltamivir class

Antiviral for influenza A and B viruses.

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Protease Inhibitors

A class of antiviral drugs that block the HIV protease enzyme, preventing the virus from assembling its structural proteins and becoming infectious.

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Ritonavir (Norvir)

A protease inhibitor commonly used in HIV therapy, often in combination with other antiretrovirals.

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Zanamivir delivery

Antiviral medication taken via inhaled powder.

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Combination Therapy

Treatment for HIV involving a combination of at least three different antivirals from the same or different classes, often with long-term use like maintenance therapy.

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Acyclovir indication

Antiviral against Herpes simplex and Varicella-Zoster viruses.

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Viral nature (basic)

Small infectious agents that need host cells to replicate.

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Influenza symptoms

Headache, fever, fatigue, sinus pain, coughing.

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Antiviral MOA (general)

Targets viral replication cycle, preventing virus spread.

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Viral infection types example

Influenza, shingles, cold sores, viral hepatitis, HIV.

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Viral Replication

Viral reproduction requires a host cell.

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Terbinafine dosage forms

Tablets, cream, and spray.

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Combivir Side Effects

Combivir, an HIV medication, can cause a range of side effects from mild to severe, including nausea, vomiting, diarrhea, liver toxicity, and even pancreatitis.

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Combivir Counseling Importance

Patients taking Combivir need thorough counseling to prepare them for potential side effects, discuss treatment goals, address adherence challenges, review administration instructions, and prevent drug interactions.

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Combivir Drug Interactions

Many drugs interact with Combivir due to its effects on liver enzymes and metabolism, making careful monitoring essential.

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Anthelmintics: What are they?

Anthelmintics are medications used to treat infections caused by parasitic worms, such as pinworms, roundworms, and tapeworms.

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How do worm infections occur?

Worm infections happen when you ingest worm eggs found in contaminated food or soil.

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Common Symptoms of Worm Infections

Symptoms of worm infections include diarrhea, cramping, nausea, vomiting, loss of appetite, and intense itching.

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Mebendazole (Vermox): MOA

Mebendazole inhibits the uptake of glucose by worms, preventing their development and maturation.

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Pyrantel Pamoate (Combantrin): MOA

Pyrantel pamoate works by affecting cholinesterases, causing neuromuscular blockade in worms, which paralyzes them.

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Malaria: How is it transmitted?

Malaria is transmitted to humans through the bite of an infected mosquito carrying the parasite Plasmodium.

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Malaria: Stages of Infection

Malaria starts with liver invasion, initially without symptoms. Mature protozoa then enter the bloodstream, causing red blood cell rupture, leading to chills, fevers, and potential convulsions.

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Study Notes

Antifungal Drugs

  • Local Infections: Nystatin (Nilstatin, Mycostatin), Terbinafine (Lamisil), Miconazole (Micatin, Monistat), Terconazole (Terazol), Clotrimazole (Canesten), Tolnaftate (Tinactin), Metronidazole (Flagyl, Metrogel) are used for common conditions such as athlete's foot, vaginal yeast infections, and thrush. Many also treat other infections.

  • Systemic Infections: Amphotericin B (Fungizone, Abelcet, AmBisome), Fluconazole (Diflucan), Itraconazole (Sporanox), and Ketoconazole (Nizoral) are used for systemic fungal infections. These may also be used topically.

  • Indications (Dermatophytic): Antifungals treat infections of hair, skin, nails, and vaginal folds, caused by conditions like athlete's foot, yeast infections, and thrush.

  • Important Considerations: Antifungals can take a week or longer to show results. Some are available as oral or topical medications. Patients with chronic conditions (diabetes, immunocompromised) are at higher risk of fungal infections and need careful consideration.

Amphotericin B

  • Brand Names: Fungizone, Abelcet, AmBisome
  • Indications: Serious fungal infections (septicemia, endocarditis, pulmonary and urinary tract infections)
  • Mechanism of Action (MOA): Alters cell membrane permeability, creates pores. Leads to cell death.
  • Supplied: Parenteral only (IV)
  • Adverse Effects: Chills, fever, nausea, vomiting, hepatic failure, decreased renal function, thrombophlebitis, anemia, allergic dermatitis.

Nazol

  • Hepatotoxicity (Liver Toxicity): Nazol drugs are very liver toxic.
  • Mechanism of Action (MOA): Selective inhibitors of sterol methylation, disrupting fungal cell membranes, leading to cell death or growth inhibition. Used in local and systemic infections.

Nystatin

  • Indications: Intestinal, oral, cutaneous, vaginal candidiasis (mild to moderate cases)

  • MOA: Similar to amphotericin B, creates pores in the cell membrane, increasing permeability, ultimately causing cell death.

  • Supplied: Oral tablets, oral suspension, topical cream/ointment, vaginal tablets/creams

  • Adverse Effects: GI intolerance (nausea, vomiting, diarrhea, abdominal pain) at higher doses. Usually well tolerated.

Terbinafine

  • Indications: Fungal infections of the skin, hair, and nails.

  • MOA: Interferes with cell membrane sterols, maintaining fluidity and stability.

  • Supplied: Tablets, cream, spray

  • Adverse Effects: GI intolerance, skin rash, pruritus, and hepatotoxicity. (Liver function tests might be required). Topical: burning, redness, itching.

Other Antiviral Drugs (Lecture Notes)

  • Classes: Cyclic Amines, Neuraminidase Inhibitors, Nucleoside Analogues, Non-nucleoside RTI's, Protease Inhibitors

  • Indications: Primarily against influenza, herpes simplex, varicella-zoster, hepatitis C, HIV, etc.

  • Adverse Effects: Vary considerably based on the specific drug. Some common effects include skin rash, nausea, vomiting, diarrhea, headache, confusion, and fatigue. Some necessitate dose adjustments or monitoring based on renal or hepatic function.

Viruses

  • Small Infectious Agents: Replicate inside living cells only.

  • Diseases: Influenza, shingles, cold sores, viral hepatitis, HIV

  • Flu/COVID Technician Role: Cold chain maintenance, appointment scheduling, initial patient history, ensuring proper equipment, and compliance with procedures.

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