Podcast
Questions and Answers
Which antifungal is primarily used for systemic infections?
Which antifungal is primarily used for systemic infections?
- Nystatin
- Terbinafine
- Clotrimazole
- Amphotericin B (correct)
What type of infections is Nystatin mainly indicated for?
What type of infections is Nystatin mainly indicated for?
- Autoimmune diseases
- Localized infections (correct)
- Systemic infections
- Dermatophytic infections
Which antifungal can also serve as an antibiotic?
Which antifungal can also serve as an antibiotic?
- Metronidazole (correct)
- Terbinafine
- Itraconazole
- Fluconazole
What is a common use for Terbinafine?
What is a common use for Terbinafine?
Which patient group is at higher risk when using systemic antifungals?
Which patient group is at higher risk when using systemic antifungals?
Which medication is primarily used for the prophylaxis of Influenza A in susceptible groups?
Which medication is primarily used for the prophylaxis of Influenza A in susceptible groups?
What is the mechanism of action of neuraminidase inhibitors such as Oseltamivir?
What is the mechanism of action of neuraminidase inhibitors such as Oseltamivir?
Which drug is indicated for the treatment of herpes simplex and herpes zoster?
Which drug is indicated for the treatment of herpes simplex and herpes zoster?
What is the major advantage of Famciclovir over Acyclovir in terms of dosing?
What is the major advantage of Famciclovir over Acyclovir in terms of dosing?
Which medication is known for its application in treating cytomegalovirus retinitis in immunocompromised patients?
Which medication is known for its application in treating cytomegalovirus retinitis in immunocompromised patients?
Which side effect is specifically associated with the inhalation use of Relenza?
Which side effect is specifically associated with the inhalation use of Relenza?
What key feature distinguishes nucleoside analogs like Acyclovir from non-nucleoside reverse transcriptase inhibitors?
What key feature distinguishes nucleoside analogs like Acyclovir from non-nucleoside reverse transcriptase inhibitors?
What type of patients require dose adjustments for Amantadine due to renal or hepatic issues?
What type of patients require dose adjustments for Amantadine due to renal or hepatic issues?
What is a common symptom experienced by females infected with Trichomonas vaginalis?
What is a common symptom experienced by females infected with Trichomonas vaginalis?
Which drug is indicated for the treatment of both Trichomonas infection and E. histolytica?
Which drug is indicated for the treatment of both Trichomonas infection and E. histolytica?
What is the recommended dosage of Metronidazole for treating Trichomoniasis?
What is the recommended dosage of Metronidazole for treating Trichomoniasis?
What significant interaction should be avoided while taking Metronidazole?
What significant interaction should be avoided while taking Metronidazole?
Which gastrointestinal infection is NOT treated by Paramomycin?
Which gastrointestinal infection is NOT treated by Paramomycin?
What is the primary mechanism of action for non-nucleoside reverse transcriptase inhibitors (RTIs)?
What is the primary mechanism of action for non-nucleoside reverse transcriptase inhibitors (RTIs)?
Which of the following is a common adverse effect associated with efavirenz (Sustiva)?
Which of the following is a common adverse effect associated with efavirenz (Sustiva)?
Which drug serves a unique purpose in treating both HIV and chronic hepatitis B when evidence of Hep B replication is present?
Which drug serves a unique purpose in treating both HIV and chronic hepatitis B when evidence of Hep B replication is present?
What type of medications are commonly used in combination to effectively treat HIV?
What type of medications are commonly used in combination to effectively treat HIV?
What is a primary side effect of HIV medications such as Combivir?
What is a primary side effect of HIV medications such as Combivir?
What is a notable feature of the adverse effects of Nevirapine (Viramune)?
What is a notable feature of the adverse effects of Nevirapine (Viramune)?
Which substance is an example of a protease inhibitor used in HIV treatment?
Which substance is an example of a protease inhibitor used in HIV treatment?
What is the mechanism of action (MOA) of Mebendazole?
What is the mechanism of action (MOA) of Mebendazole?
Which of the following is a recommended precaution for preventing worm infections?
Which of the following is a recommended precaution for preventing worm infections?
Which of the following is a characteristic of combination therapy for HIV?
Which of the following is a characteristic of combination therapy for HIV?
Which drug is known to inhibit CYP 3A4 and is a non-nucleoside RTI?
Which drug is known to inhibit CYP 3A4 and is a non-nucleoside RTI?
What adverse effect can Pyrvinium Pamoate cause?
What adverse effect can Pyrvinium Pamoate cause?
Which drug is indicated for both roundworms and pinworms?
Which drug is indicated for both roundworms and pinworms?
What type of infections are anthelmintics primarily used to treat?
What type of infections are anthelmintics primarily used to treat?
What condition is characterized by high fevers and chills due to a protozoal infection?
What condition is characterized by high fevers and chills due to a protozoal infection?
What is a common side effect of antimalarial drugs?
What is a common side effect of antimalarial drugs?
What is the desired outcome when treating worm infections?
What is the desired outcome when treating worm infections?
Which of the following drugs is known for its cholinesterase effects causing neuromuscular blockade?
Which of the following drugs is known for its cholinesterase effects causing neuromuscular blockade?
What is the mechanism of action of the antifungal treatment mentioned?
What is the mechanism of action of the antifungal treatment mentioned?
Which of the following is an indication for the use of Amantadine?
Which of the following is an indication for the use of Amantadine?
What is a common adverse effect associated with high oral doses of the antifungal medication?
What is a common adverse effect associated with high oral doses of the antifungal medication?
Which formulation of antifungal medication is available as a topical cream?
Which formulation of antifungal medication is available as a topical cream?
What is the preferred dosage form of Oseltamivir?
What is the preferred dosage form of Oseltamivir?
Which of the following is NOT an antiviral drug?
Which of the following is NOT an antiviral drug?
What instruction is important for patients taking the oral suspension of the antifungal medication?
What instruction is important for patients taking the oral suspension of the antifungal medication?
Which symptom is most commonly associated with Influenza?
Which symptom is most commonly associated with Influenza?
What type of infections does Ribavirin primarily treat?
What type of infections does Ribavirin primarily treat?
Which of the following is a common adverse effect of oral antivirals for HIV treatment?
Which of the following is a common adverse effect of oral antivirals for HIV treatment?
What is the primary role of viruses in the context of diseases?
What is the primary role of viruses in the context of diseases?
Which antiviral drug is administered via inhalation powder?
Which antiviral drug is administered via inhalation powder?
What is the recommended action if a patient experiences GI intolerance after taking a higher dose of an antifungal?
What is the recommended action if a patient experiences GI intolerance after taking a higher dose of an antifungal?
Which molecule is crucial for maintaining cell membrane stability that antifungal treatments target?
Which molecule is crucial for maintaining cell membrane stability that antifungal treatments target?
Flashcards
Antifungal Drugs
Antifungal Drugs
Medicines used to treat fungal infections, either localized (on the skin, nails, etc.) or systemic (throughout the body).
Local Antifungal Drugs
Local Antifungal Drugs
Antifungal medications applied directly to the affected area, like skin or vagina.
Systemic Antifungal Drugs
Systemic Antifungal Drugs
Antifungal medicines that travel throughout the body to fight widespread infections.
Common Antifungal Indications
Common Antifungal Indications
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Antifungal Risk Factors
Antifungal Risk Factors
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Amantadine (Symmetrel)
Amantadine (Symmetrel)
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Neuraminidase Inhibitors
Neuraminidase Inhibitors
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Oseltamivir (Tamiflu) AND Zanamivir (Relenza)
Oseltamivir (Tamiflu) AND Zanamivir (Relenza)
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Acyclovir (Zovirax)
Acyclovir (Zovirax)
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Famciclovir (Famvir)
Famciclovir (Famvir)
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Valacyclovir (Valtrex)
Valacyclovir (Valtrex)
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Ganciclovir (Cytovene)
Ganciclovir (Cytovene)
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Ribavirin (Ibayrr)
Ribavirin (Ibayrr)
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Trichomoniasis
Trichomoniasis
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Metronidazole (Flagyl)
Metronidazole (Flagyl)
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Metronidazole Side Effects
Metronidazole Side Effects
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Metronidazole and Alcohol
Metronidazole and Alcohol
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Chloroquine (Aralen)
Chloroquine (Aralen)
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Non-Nucleoside RTIs
Non-Nucleoside RTIs
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Terbinafine indications
Terbinafine indications
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Terbinafine MOA
Terbinafine MOA
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Efavirenz (Sustiva)
Efavirenz (Sustiva)
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Nevirapine (Viramune)
Nevirapine (Viramune)
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Oral Terbinafine side effects
Oral Terbinafine side effects
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Nucleoside Analogue RTIs
Nucleoside Analogue RTIs
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Influenza antiviral
Influenza antiviral
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Zidovudine (Retrovir) (AZT)
Zidovudine (Retrovir) (AZT)
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Amantadine indication
Amantadine indication
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Oseltamivir class
Oseltamivir class
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Protease Inhibitors
Protease Inhibitors
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Ritonavir (Norvir)
Ritonavir (Norvir)
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Zanamivir delivery
Zanamivir delivery
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Combination Therapy
Combination Therapy
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Acyclovir indication
Acyclovir indication
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Viral nature (basic)
Viral nature (basic)
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Influenza symptoms
Influenza symptoms
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Antiviral MOA (general)
Antiviral MOA (general)
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Viral infection types example
Viral infection types example
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Viral Replication
Viral Replication
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Terbinafine dosage forms
Terbinafine dosage forms
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Combivir Side Effects
Combivir Side Effects
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Combivir Counseling Importance
Combivir Counseling Importance
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Combivir Drug Interactions
Combivir Drug Interactions
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Anthelmintics: What are they?
Anthelmintics: What are they?
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How do worm infections occur?
How do worm infections occur?
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Common Symptoms of Worm Infections
Common Symptoms of Worm Infections
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Mebendazole (Vermox): MOA
Mebendazole (Vermox): MOA
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Pyrantel Pamoate (Combantrin): MOA
Pyrantel Pamoate (Combantrin): MOA
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Malaria: How is it transmitted?
Malaria: How is it transmitted?
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Malaria: Stages of Infection
Malaria: Stages of Infection
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Study Notes
Antifungal Drugs
-
Local Infections: Nystatin (Nilstatin, Mycostatin), Terbinafine (Lamisil), Miconazole (Micatin, Monistat), Terconazole (Terazol), Clotrimazole (Canesten), Tolnaftate (Tinactin), Metronidazole (Flagyl, Metrogel) are used for common conditions such as athlete's foot, vaginal yeast infections, and thrush. Many also treat other infections.
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Systemic Infections: Amphotericin B (Fungizone, Abelcet, AmBisome), Fluconazole (Diflucan), Itraconazole (Sporanox), and Ketoconazole (Nizoral) are used for systemic fungal infections. These may also be used topically.
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Indications (Dermatophytic): Antifungals treat infections of hair, skin, nails, and vaginal folds, caused by conditions like athlete's foot, yeast infections, and thrush.
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Important Considerations: Antifungals can take a week or longer to show results. Some are available as oral or topical medications. Patients with chronic conditions (diabetes, immunocompromised) are at higher risk of fungal infections and need careful consideration.
Amphotericin B
- Brand Names: Fungizone, Abelcet, AmBisome
- Indications: Serious fungal infections (septicemia, endocarditis, pulmonary and urinary tract infections)
- Mechanism of Action (MOA): Alters cell membrane permeability, creates pores. Leads to cell death.
- Supplied: Parenteral only (IV)
- Adverse Effects: Chills, fever, nausea, vomiting, hepatic failure, decreased renal function, thrombophlebitis, anemia, allergic dermatitis.
Nazol
- Hepatotoxicity (Liver Toxicity): Nazol drugs are very liver toxic.
- Mechanism of Action (MOA): Selective inhibitors of sterol methylation, disrupting fungal cell membranes, leading to cell death or growth inhibition. Used in local and systemic infections.
Nystatin
-
Indications: Intestinal, oral, cutaneous, vaginal candidiasis (mild to moderate cases)
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MOA: Similar to amphotericin B, creates pores in the cell membrane, increasing permeability, ultimately causing cell death.
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Supplied: Oral tablets, oral suspension, topical cream/ointment, vaginal tablets/creams
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Adverse Effects: GI intolerance (nausea, vomiting, diarrhea, abdominal pain) at higher doses. Usually well tolerated.
Terbinafine
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Indications: Fungal infections of the skin, hair, and nails.
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MOA: Interferes with cell membrane sterols, maintaining fluidity and stability.
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Supplied: Tablets, cream, spray
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Adverse Effects: GI intolerance, skin rash, pruritus, and hepatotoxicity. (Liver function tests might be required). Topical: burning, redness, itching.
Other Antiviral Drugs (Lecture Notes)
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Classes: Cyclic Amines, Neuraminidase Inhibitors, Nucleoside Analogues, Non-nucleoside RTI's, Protease Inhibitors
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Indications: Primarily against influenza, herpes simplex, varicella-zoster, hepatitis C, HIV, etc.
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Adverse Effects: Vary considerably based on the specific drug. Some common effects include skin rash, nausea, vomiting, diarrhea, headache, confusion, and fatigue. Some necessitate dose adjustments or monitoring based on renal or hepatic function.
Viruses
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Small Infectious Agents: Replicate inside living cells only.
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Diseases: Influenza, shingles, cold sores, viral hepatitis, HIV
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Flu/COVID Technician Role: Cold chain maintenance, appointment scheduling, initial patient history, ensuring proper equipment, and compliance with procedures.
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