30 Questions
What is the primary purpose of using topical antifungal agents?
To manage mucocutaneous infections caused by Candida albicans
What is the role of corticosteroids in oral fungal infections?
They suppress immunity, making individuals susceptible to opportunistic infections
What is the classification of antifungal drugs that includes ketoconazole, miconazole, and clotrimazole?
Imidazoles
What is the result of systemic drug therapy on the oral microflora?
It predisposes the mouth to various bacterial and fungal infections
What is the primary purpose of antifungal drug therapy in dentistry?
To manage oral fungal infections
Which of the following antifungal drugs is an example of an antimetabolite?
Flucytosine
What is the primary mechanism of action of Amphotericin B?
Binding to ergosterol and forming pores in the fungal cell membrane
Why is Amphotericin B not suitable for oral administration?
It is not absorbed from the gut
What is the primary reason azoles have replaced Amphotericin B in the treatment of many fungal diseases?
Azoles are less toxic
What is the most common adverse effect of Amphotericin B therapy?
Nephrotoxicity
Why is intrathecal administration of Amphotericin B essential for the treatment of fungal meningitis?
To cross the blood-brain barrier
What is the effect of Amphotericin B on erythropoietin production?
It decreases production
What is the similarity between the structure of Nystatin and Amphotericin B?
They have similar structures
Why is Nystatin only used topically?
It is highly toxic for systemic use
What is the mechanism of action of Azoles?
They inhibit the activity of 14-demethylase enzyme
Why is the bioavailability of Ketoconazole reduced by certain drugs?
Drugs reduce the absorption of Ketoconazole in acidic environments
What is the uses of Nystatin oral suspension in dentistry?
It is used to treat oral candidiasis, angular cheilitis and antibiotic-associated stomatitis
What is the dosage of Nystatin oral suspension for oral candidiasis?
5 mL to be shaken and swallowed 4-5 times a day for 14 days
What is the mechanism of action of fluconazole?
It inhibits enzymes
What is the recommended dosage of fluconazole for oral candidiasis?
200 mg start, then 100 mg daily for next 14 days
What is the contraindication of fluconazole during pregnancy?
Due to its teratogenic effect
Which of the following antifungal drugs is commonly used for oral candidiasis?
All of the above
What is a potential side effect of fluconazole?
Hepatic necrosis
What instruction should be given to the patient regarding the use of antifungal agents?
To apply the medication topically
What is the primary route of excretion for ketoconazole?
Feces
What is a unique feature of fluconazole distribution in the body?
Poorly bound to plasma proteins
What is a common adverse effect of ketoconazole in males?
All of the above
What is the primary mechanism of ketoconazole's drug interaction with sulfonylureas?
Inhibition of metabolism
What is a difference between ketoconazole and fluconazole in terms of their antifungal spectrum?
Fluconazole has a broader spectrum
What is a common side effect of fluconazole therapy?
Nausea and vomiting
Test your knowledge of antifungal drugs, their pharmacology, and implications in dentistry. Learn how to manage oral fungal infections with antifungal drugs. Familiarize yourself with the different types of fungal diseases and their treatments.
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