Antifungal Drugs in Dentistry

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Questions and Answers

What is the primary purpose of using topical antifungal agents?

  • To manage mucocutaneous infections caused by Candida albicans (correct)
  • To boost immunity against fungal infections
  • To prevent oral bacterial infections
  • To treat systemic fungal infections

What is the role of corticosteroids in oral fungal infections?

  • They enhance immunity against fungal infections
  • They suppress immunity, making individuals susceptible to opportunistic infections (correct)
  • They reduce the risk of oral bacterial infections
  • They have no effect on oral fungal infections

What is the classification of antifungal drugs that includes ketoconazole, miconazole, and clotrimazole?

  • Antifungal antibiotics
  • Imidazoles (correct)
  • Triazoles
  • Antimetabolites

What is the result of systemic drug therapy on the oral microflora?

<p>It predisposes the mouth to various bacterial and fungal infections (C)</p> Signup and view all the answers

What is the primary purpose of antifungal drug therapy in dentistry?

<p>To manage oral fungal infections (C)</p> Signup and view all the answers

Which of the following antifungal drugs is an example of an antimetabolite?

<p>Flucytosine (D)</p> Signup and view all the answers

What is the primary mechanism of action of Amphotericin B?

<p>Binding to ergosterol and forming pores in the fungal cell membrane (A)</p> Signup and view all the answers

Why is Amphotericin B not suitable for oral administration?

<p>It is not absorbed from the gut (B)</p> Signup and view all the answers

What is the primary reason azoles have replaced Amphotericin B in the treatment of many fungal diseases?

<p>Azoles are less toxic (B)</p> Signup and view all the answers

What is the most common adverse effect of Amphotericin B therapy?

<p>Nephrotoxicity (D)</p> Signup and view all the answers

Why is intrathecal administration of Amphotericin B essential for the treatment of fungal meningitis?

<p>To cross the blood-brain barrier (A)</p> Signup and view all the answers

What is the effect of Amphotericin B on erythropoietin production?

<p>It decreases production (A)</p> Signup and view all the answers

What is the similarity between the structure of Nystatin and Amphotericin B?

<p>They have similar structures (D)</p> Signup and view all the answers

Why is Nystatin only used topically?

<p>It is highly toxic for systemic use (D)</p> Signup and view all the answers

What is the mechanism of action of Azoles?

<p>They inhibit the activity of 14-demethylase enzyme (D)</p> Signup and view all the answers

Why is the bioavailability of Ketoconazole reduced by certain drugs?

<p>Drugs reduce the absorption of Ketoconazole in acidic environments (A)</p> Signup and view all the answers

What is the uses of Nystatin oral suspension in dentistry?

<p>It is used to treat oral candidiasis, angular cheilitis and antibiotic-associated stomatitis (C)</p> Signup and view all the answers

What is the dosage of Nystatin oral suspension for oral candidiasis?

<p>5 mL to be shaken and swallowed 4-5 times a day for 14 days (D)</p> Signup and view all the answers

What is the mechanism of action of fluconazole?

<p>It inhibits enzymes (C)</p> Signup and view all the answers

What is the recommended dosage of fluconazole for oral candidiasis?

<p>200 mg start, then 100 mg daily for next 14 days (C)</p> Signup and view all the answers

What is the contraindication of fluconazole during pregnancy?

<p>Due to its teratogenic effect (A)</p> Signup and view all the answers

Which of the following antifungal drugs is commonly used for oral candidiasis?

<p>All of the above (D)</p> Signup and view all the answers

What is a potential side effect of fluconazole?

<p>Hepatic necrosis (A)</p> Signup and view all the answers

What instruction should be given to the patient regarding the use of antifungal agents?

<p>To apply the medication topically (A)</p> Signup and view all the answers

What is the primary route of excretion for ketoconazole?

<p>Feces (A)</p> Signup and view all the answers

What is a unique feature of fluconazole distribution in the body?

<p>Poorly bound to plasma proteins (C)</p> Signup and view all the answers

What is a common adverse effect of ketoconazole in males?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary mechanism of ketoconazole's drug interaction with sulfonylureas?

<p>Inhibition of metabolism (D)</p> Signup and view all the answers

What is a difference between ketoconazole and fluconazole in terms of their antifungal spectrum?

<p>Fluconazole has a broader spectrum (D)</p> Signup and view all the answers

What is a common side effect of fluconazole therapy?

<p>Nausea and vomiting (D)</p> Signup and view all the answers

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