Antifungal Drugs in Dentistry

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What is the primary purpose of using topical antifungal agents?

To manage mucocutaneous infections caused by Candida albicans (correct)

To boost immunity against fungal infections

To prevent oral bacterial infections

To treat systemic fungal infections

What is the role of corticosteroids in oral fungal infections?

They enhance immunity against fungal infections

They suppress immunity, making individuals susceptible to opportunistic infections (correct)

They reduce the risk of oral bacterial infections

They have no effect on oral fungal infections

What is the classification of antifungal drugs that includes ketoconazole, miconazole, and clotrimazole?

Antifungal antibiotics

Imidazoles (correct)

Triazoles

Antimetabolites

What is the result of systemic drug therapy on the oral microflora?

It predisposes the mouth to various bacterial and fungal infections Signup and view all the answers

What is the primary purpose of antifungal drug therapy in dentistry?

To manage oral fungal infections Signup and view all the answers

Which of the following antifungal drugs is an example of an antimetabolite?

Flucytosine Signup and view all the answers

What is the primary mechanism of action of Amphotericin B?

Binding to ergosterol and forming pores in the fungal cell membrane Signup and view all the answers

Why is Amphotericin B not suitable for oral administration?

It is not absorbed from the gut Signup and view all the answers

What is the primary reason azoles have replaced Amphotericin B in the treatment of many fungal diseases?

Azoles are less toxic Signup and view all the answers

What is the most common adverse effect of Amphotericin B therapy?

Nephrotoxicity Signup and view all the answers

Why is intrathecal administration of Amphotericin B essential for the treatment of fungal meningitis?

To cross the blood-brain barrier Signup and view all the answers

What is the effect of Amphotericin B on erythropoietin production?

It decreases production Signup and view all the answers

What is the similarity between the structure of Nystatin and Amphotericin B?

They have similar structures Signup and view all the answers

Why is Nystatin only used topically?

It is highly toxic for systemic use Signup and view all the answers

What is the mechanism of action of Azoles?

They inhibit the activity of 14-demethylase enzyme Signup and view all the answers

Why is the bioavailability of Ketoconazole reduced by certain drugs?

Drugs reduce the absorption of Ketoconazole in acidic environments Signup and view all the answers

What is the uses of Nystatin oral suspension in dentistry?

It is used to treat oral candidiasis, angular cheilitis and antibiotic-associated stomatitis Signup and view all the answers

What is the dosage of Nystatin oral suspension for oral candidiasis?

5 mL to be shaken and swallowed 4-5 times a day for 14 days Signup and view all the answers

What is the mechanism of action of fluconazole?

It inhibits enzymes Signup and view all the answers

What is the recommended dosage of fluconazole for oral candidiasis?

200 mg start, then 100 mg daily for next 14 days Signup and view all the answers

What is the contraindication of fluconazole during pregnancy?

Due to its teratogenic effect Signup and view all the answers

Which of the following antifungal drugs is commonly used for oral candidiasis?

All of the above Signup and view all the answers

What is a potential side effect of fluconazole?

Hepatic necrosis Signup and view all the answers

What instruction should be given to the patient regarding the use of antifungal agents?

To apply the medication topically Signup and view all the answers

What is the primary route of excretion for ketoconazole?

Feces Signup and view all the answers

What is a unique feature of fluconazole distribution in the body?

Poorly bound to plasma proteins Signup and view all the answers

What is a common adverse effect of ketoconazole in males?

All of the above Signup and view all the answers

What is the primary mechanism of ketoconazole's drug interaction with sulfonylureas?

Inhibition of metabolism Signup and view all the answers

What is a difference between ketoconazole and fluconazole in terms of their antifungal spectrum?

Fluconazole has a broader spectrum Signup and view all the answers

What is a common side effect of fluconazole therapy?

Nausea and vomiting Signup and view all the answers