Quiz Antidepressants Drugs
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Questions and Answers

What is a potential adverse effect associated with Fluoxetine?

  • Persistent hypernatremia
  • Syndrome of inappropriate antidiuretic hormone secretion (correct)
  • Excessive sedation
  • Increased blood glucose levels

    • Which type of antidepressants does Amitriptyline belong to?

  • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Tricyclic Antidepressants (TCAs) (correct)
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

    • What mechanism of action do Tricyclic Antidepressants (TCAs) primarily use?

  • Increase production of serotonin
  • Selective blockade of serotonin receptors
  • Blockade of norepinephrine and serotonin reuptake (correct)
  • Inhibition of monoamine oxidase

    • What is a common risk associated with the overdose of Tricyclic Antidepressants?

    <p>Severe toxicity</p> Signup and view all the answers

    How do SNRIs like Venlafaxine and Nortriptyline function?

    <p>By blocking the reuptake of norepinephrine and serotonin</p> Signup and view all the answers

    Which class of medication requires the avoidance of foods containing tyramine?

    <p>MAOIs</p> Signup and view all the answers

    What is the primary risk associated with TCAs when taken in overdose?

    <p>Life-threatening cardiac dysrhythmia</p> Signup and view all the answers

    Which of the following is FALSE regarding Duloxetine and Venlafaxine?

    <p>They produce significant sedative side effects.</p> Signup and view all the answers

    Which class of drugs includes agents known for inducing seizures at therapeutic levels?

    <p>TCAs</p> Signup and view all the answers

    What is a notable side effect caused by older TCAs that newer SSRIs typically do not cause?

    <p>Sexual dysfunction</p> Signup and view all the answers

    Which drug is known as the first approved treatment for bulimia nervosa?

    <p>Fluoxetine</p> Signup and view all the answers

    What type of side effects do TCAs commonly produce?

    <p>Muscarinic and α-adrenoceptor blockade</p> Signup and view all the answers

    Which of the following medications is NOT commonly categorized as an SSRI?

    <p>Venlafaxine</p> Signup and view all the answers

    Study Notes

    MAOIs

    • Foods containing tyramine should be avoided when taking MAOIs.
    • MAOIs are not considered drugs of choice in the treatment of depression due to potential interactions with other drugs and food.
    • Hypertensive crisis can occur with MAOIs alone or after taking sympathomimetic amines or eating tyramine-containing foods.

    SSRIs

    • Fluoxetine (Prozac) is an SSRI that can cause more drug interactions than other SSRIs.
    • Fluoxetine can impair blood glucose regulation in diabetic patients.
    • Fluoxetine can cause syndrome of inappropriate antidiuretic hormone secretion (SIADH) characterized by persistent hyponatremia and elevated urine osmolality.
    • Fluoxetine is the first drug approved for the treatment of bulimia nervosa, is effective in the management of anorexia nervosa and obsessive-compulsive disorder, and is one of the most popular drugs for the treatment of depression.

    SNRIs

    • Venlafaxine and Duloxetine are structurally unique antidepressants that strongly inhibit the reuptake of both norepinephrine and serotonin.
    • They have a side effect profile similar to SSRIs.
    • Venlafaxine and duloxetine have few autonomic, sedative, or cardiovascular side effects.

    TCAs

    • TCAs are highly effective in the treatment of depression and other disorders, but they are associated with a high incidence of adverse effects.
    • TCAs, including amitriptyline, imipramine, clomipramine, desipramine, and nortriptyline, block the neuronal reuptake of norepinephrine and serotonin.
    • TCAs block the reuptake transporter proteins, called the norepinephrine transporter (NET) and serotonin transporter (SERT) to varying degrees.
    • TCAs produce autonomic side effects by blocking muscarinic and α-adrenoceptors.
    • TCAs can cause marked sedation, which can be beneficial for promoting sleep when taken at bedtime.
    • TCAs lower the seizure threshold and can induce seizures at both therapeutic and toxic serum concentrations.
    • TCA overdose can cause life-threatening cardiac dysrhythmia, marked autonomic effects, excessive sedation, and seizures.
    • TCA overdose often manifests as a wide QRS complex tachycardia.
    • The older TCAs can cause all of the adverse effects listed from A through D except sexual dysfunction.
    • Newer SSRIs, such as fluoxetine, are more likely to cause sexual dysfunction, including priapism and impotency.

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    Description

    This quiz covers the key features and important considerations of MAOIs, SSRIs, and SNRIs in the treatment of depression. It highlights the risks associated with MAOIs, the effects of Fluoxetine, and the unique properties of Venlafaxine and Duloxetine. Test your knowledge on these critical antidepressant classes.

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