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Anticoagulation Therapy: Warfarin vs. Direct Oral Anticoagulants

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Anticoagulation Therapy: Warfarin vs. Direct Oral Anticoagulants

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Questions and Answers

What is the major limitation of warfarin?

Unpredictable dose response

Slow reversibility

Unwanted food interactions

All of the above (correct)

What is the mechanism of action of rivaroxaban?

Inhibition of factor Xa (correct)

Stimulation of LDL receptors

Inhibition of platelet activation

Inhibition of thrombin

Which of the following is NOT a characteristic of apixaban?

Renal clearance (correct)

Twice daily dosing

Hepatic clearance

Once daily maintenance dosing

What is the mechanism of action of PCSK9 inhibitors?

Inhibition of PCSK9, increasing LDL receptors Signup and view all the answers

What is the indication for alirocumab?

Adjunct to diet and maximally tolerated statin for HeFH or clinical atherosclerotic CVD Signup and view all the answers

What is the major advantage of PCSK9 inhibitors?

Well-tolerated, safe, and highly effective Signup and view all the answers

Evolocumab is indicated in which of the following?

HeFH and HoFH Signup and view all the answers

What is the mechanism of action of carbamazepine?

Prolongs inactivation of voltage-gated sodium channels and potentiates the action of post-synaptic GABA Signup and view all the answers

What is a common adverse effect of phenytoin?

Gum hypertrophy Signup and view all the answers

What is the mechanism of action of phenobarbital?

GABA receptor mediated, binding to GABA receptor and enhancing GABA effects Signup and view all the answers

What is the indication of sodium valproate?

Partial, absence, and generalised seizures Signup and view all the answers

What is the adverse effect of phenytoin that affects the bone?

Decreased bone density Signup and view all the answers