Anticoagulation Therapy: Warfarin vs. Direct Oral Anticoagulants
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Questions and Answers

What is the major limitation of warfarin?

  • Unpredictable dose response
  • Slow reversibility
  • Unwanted food interactions
  • All of the above (correct)

What is the mechanism of action of rivaroxaban?

  • Inhibition of factor Xa (correct)
  • Stimulation of LDL receptors
  • Inhibition of platelet activation
  • Inhibition of thrombin

Which of the following is NOT a characteristic of apixaban?

  • Renal clearance (correct)
  • Twice daily dosing
  • Hepatic clearance
  • Once daily maintenance dosing

What is the mechanism of action of PCSK9 inhibitors?

<p>Inhibition of PCSK9, increasing LDL receptors (A)</p> Signup and view all the answers

What is the indication for alirocumab?

<p>Adjunct to diet and maximally tolerated statin for HeFH or clinical atherosclerotic CVD (C)</p> Signup and view all the answers

What is the major advantage of PCSK9 inhibitors?

<p>Well-tolerated, safe, and highly effective (A)</p> Signup and view all the answers

Evolocumab is indicated in which of the following?

<p>HeFH and HoFH (D)</p> Signup and view all the answers

What is the mechanism of action of carbamazepine?

<p>Prolongs inactivation of voltage-gated sodium channels and potentiates the action of post-synaptic GABA (B)</p> Signup and view all the answers

What is a common adverse effect of phenytoin?

<p>Gum hypertrophy (C)</p> Signup and view all the answers

What is the mechanism of action of phenobarbital?

<p>GABA receptor mediated, binding to GABA receptor and enhancing GABA effects (C)</p> Signup and view all the answers

What is the indication of sodium valproate?

<p>Partial, absence, and generalised seizures (C)</p> Signup and view all the answers

What is the adverse effect of phenytoin that affects the bone?

<p>Decreased bone density (C)</p> Signup and view all the answers

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