Master the Basics of Anticoagulation Therapy

1. Haemostasis involves vasoconstriction, primary and secondary haemostasis, and fibrinolysis.
2. Tests to assess coagulation cascade include PT and PTT assays.
3. Anticoagulation therapy includes Warfarin, Heparin, Clopidogrel, Aspirin, Tirofiban, and Alteplase.
4. Warfarin inhibits Vitamin K reductase, while Heparin enhances activity of ATIII.
5. Clopidogrel is an ADP receptor antagonist, while Aspirin irreversibly inhibits COX.
6. Tirofiban is a GPIIb/IIIA receptor antagonist, while Alteplase cleaves plasminogen to plasmin.
7. Adverse effects of anticoagulation therapy include haemorrhage, thrombocytopaenia, osteoporosis, nausea, dizziness, peptic ulcers, worsening asthma, and Reye's syndrome.
8. Contraindications for anticoagulation therapy include pregnancy, liver disease, recent neurosurgery, active ulcer disease, uncontrolled bleeding, peptic ulcers, haemophilia, renal disease, and gout.
9. PT measures the extrinsic pathway of coagulation, while APTT measures the intrinsic pathway.
10. Alteplase is used for STEMI, ischaemic stroke, and PE, but has contraindications for recent haemorrhage and uncontrolled bleeding.

Are you knowledgeable about haemostasis and anticoagulation therapy? Test your understanding with this quiz! From vasoconstriction to fibrinolysis, this quiz covers key topics in haemostasis. You'll also be asked about common anticoagulation therapies and their mechanisms, as well as potential adverse effects and contraindications. If you're a healthcare professional or just interested in the subject, give this quiz a try and see how you do!