33 Questions
LMWH has a longer length of action compared to unfractionated heparin.
True
Hypersensitivity reactions are common in long-term heparin exposure.
False
LMWH inactivates thrombin to a greater extent than factor Xa.
False
Monitoring anti-factor Xa activity is always indicated when using LMWH.
False
LMWH has high protein and cellular binding compared to unfractionated heparin.
False
All LMWHs should be avoided in individuals with creatinine clearance above 99.
True
Warfarin therapy is usually commenced without any bridging anticoagulation.
False
Direct oral anticoagulants (DOACs) have less susceptibility to dietary and drug interaction compared to warfarin.
True
Direct thrombin inhibitors and direct factor 10a inhibitors both inhibit the formation of a fibrin clot.
True
All direct thrombin inhibitors are renally metabolized.
True
Heparin exerts its anticoagulant effect by forming a complex with antithrombin III.
True
High INR levels are associated with a low risk of bleeding.
False
Unfractionated Heparin is absorbed orally for administration.
False
Heparin can be safely administered through the intramuscular route.
False
DOACs have been found to have similar effects as other anticoagulants but do not require routine coagulation monitoring.
True
Heparin is highly positively charged upon intravenous infusion.
False
A recommended target ratio of activated partial thromboplastin time (aPTT) is 1.5 - 2.2 times the patient's aPTT.
True
Heparin has a long half-life due to slow clearance by the kidneys.
False
Heparin can effectively cross the placenta.
False
Atrial fibrillation is not considered a risk factor for stroke.
False
Direct oral anticoagulants are recommended for patients with prosthetic heart valves.
False
Direct Factor 10a Inhibitors work by inhibiting the cleavage of prothrombin to thrombin indirectly.
False
Heparin is indicated in patients with acute coronary syndrome only if they are not undergoing percutaneous coronary intervention (PCI).
False
Heparin-induced thrombocytopenia (HIT) type 1 is caused by antibody formation against heparin-platelet factor 4 complex.
False
Stopping the infusion of heparin is recommended in patients with HIT type 2.
True
The duration of anticoagulation for venous thromboembolism is solely determined by the presence of deep vein thrombosis.
False
Patients with atrial fibrillation have a higher risk of embolization if they have chronic atrial fibrillation compared to paroxysmal atrial fibrillation.
False
Bridging anticoagulation with LMWHs is not indicated for patients at low risk of thromboembolic events.
True
Initiating therapy with warfarin for patients with uncomplicated nonvalvular atrial fibrillation requires bridging with a heparin product.
False
For patients with a recent pulmonary emboli, bridging anticoagulation with a heparin product is recommended when initiating treatment.
True
Treatment duration with anticoagulation should always be the same regardless of recurrence and risk of bleeding.
False
Anticoagulation should be avoided in pregnant patients.
False
Patients with an aortic dissection or aneurysm are considered to have absolute contraindications for anticoagulation.
False
Test your knowledge on the mechanisms and indications of anticoagulants, including the inhibition of fibrin clot formation, vitamin K-dependent factors, and calcium-binding properties. Explore the use of direct thrombin inhibitors and direct factor 10a inhibitors in preventing blood clot formation.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free