Anticoagulation Mechanism Quiz

<p>Hemorrhagic disorder in fetus</p> Signup and view all the answers

<p>$ ext{Increase activity of Antithrombin III}$</p> Signup and view all the answers

<p>$ ext{Intravenously (IV)}$</p> Signup and view all the answers

<p>$ ext{Prevent their synthesis}$</p> Signup and view all the answers

<p>$ ext{Partial thromboplastin time (PTT)}$</p> Signup and view all the answers

<p>$ ext{Heparin}$</p> Signup and view all the answers

<p>$ ext{Protamine sulfate}$</p> Signup and view all the answers

<p>Nonpredictable responses to polymorphisms in CYT P450 isoforms that metabolize warfarin can lead to toxicities or underuse of the medication.</p> Signup and view all the answers

<p>Warfarin can cross the placental barrier and lead to abortion, hemorrhagic disorder in the fetus, and birth defects. It is recommended to give heparin or LMWH instead of warfarin to pregnant women.</p> Signup and view all the answers

<p>The potential risks of using Warfarin during pregnancy include crossing the placental barrier, leading to abortion, hemorrhagic disorder in the fetus, and birth defects. Heparin or LMWH is recommended as an alternative treatment for pregnant women.</p> Signup and view all the answers

<p>Heparins increase the activity of Antithrombin III, leading to the inactivation of coagulation factors IIa, VIIa, IXa, Xa, XIa, and XIIa. They are used for rapid anticoagulation in cases such as thromboses, emboli, unstable angina, disseminated intravascular coagulation (DIC), and open heart surgery. For long-term anticoagulation, they are used for conditions like thromboses, emboli, post-MI, heart valve damage, and atrial arrhythmias.</p> Signup and view all the answers

<p>The potential adverse effects of Coumarin (Warfarin) therapy include bleeding, osteoporosis, thrombocytopenia (HIT), hypersensitivity, and skin necrosis (if low protein C). Drug interactions and teratogenic effects leading to bone dysmorphogenesis are also associated with Coumarin (Warfarin) therapy.</p> Signup and view all the answers