10 Questions
What is the first clotting factor to decline in the presence of anticoagulants according to the text?
Protein C
Which enzyme is required for the regeneration of hydroquinone form of vitamin K in the clotting process?
Vitamin K epoxide reductase (VKOR)
Which CYP enzyme metabolizes S-warfarin, the more active isomer of warfarin?
CYP2C9
What is the main mechanism of action of oral anticoagulants like warfarin and phenindione?
Inhibiting the activation of vitamin K dependent clotting factors
What is the major clinical consequence of phenindione usage among patients?
Orange coloured urine
Which factor has the longest half-life among the clotting factors discussed in the text?
Factor II
Which test is considered a better option for monitoring the effect of oral anticoagulants according to the text?
International normalized ratio (INR)
What is the specific antidote mentioned for warfarin overdose in the text?
Vitamin K1
Which specific clotting factors are affected by oral anticoagulants like warfarin and dicumarol?
Clotting factors II, VII, IX, and X
Why is warfarin contra-indicated during pregnancy according to the text?
It causes fetal warfarin syndrome
Test your knowledge on the classification of anticoagulants including the warfarin group, indirect thrombin inhibitors (heparin group), and direct thrombin inhibitors. Explore oral anticoagulants drugs like warfarin, dicumarol, and acenocoumarin. Understand how these drugs work by inhibiting the activation of vitamin K dependent clotting factors.
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