Podcast
Questions and Answers
What is the first clotting factor to decline in the presence of anticoagulants according to the text?
What is the first clotting factor to decline in the presence of anticoagulants according to the text?
- Factor II
- Protein C (correct)
- Factor VII
- Factor IX
Which enzyme is required for the regeneration of hydroquinone form of vitamin K in the clotting process?
Which enzyme is required for the regeneration of hydroquinone form of vitamin K in the clotting process?
- Vitamin K epoxide reductase (VKOR) (correct)
- Thrombin
- Cytochrome P450
- Vitamin K carboxylase
Which CYP enzyme metabolizes S-warfarin, the more active isomer of warfarin?
Which CYP enzyme metabolizes S-warfarin, the more active isomer of warfarin?
- CYP3A4
- CYP1A2
- CYP2C9 (correct)
- CYP2D6
What is the main mechanism of action of oral anticoagulants like warfarin and phenindione?
What is the main mechanism of action of oral anticoagulants like warfarin and phenindione?
What is the major clinical consequence of phenindione usage among patients?
What is the major clinical consequence of phenindione usage among patients?
Which factor has the longest half-life among the clotting factors discussed in the text?
Which factor has the longest half-life among the clotting factors discussed in the text?
Which test is considered a better option for monitoring the effect of oral anticoagulants according to the text?
Which test is considered a better option for monitoring the effect of oral anticoagulants according to the text?
What is the specific antidote mentioned for warfarin overdose in the text?
What is the specific antidote mentioned for warfarin overdose in the text?
Which specific clotting factors are affected by oral anticoagulants like warfarin and dicumarol?
Which specific clotting factors are affected by oral anticoagulants like warfarin and dicumarol?
Why is warfarin contra-indicated during pregnancy according to the text?
Why is warfarin contra-indicated during pregnancy according to the text?
Flashcards
First clotting factor to decline with anticoagulants?
First clotting factor to decline with anticoagulants?
Protein C
Enzyme for vitamin K regeneration?
Enzyme for vitamin K regeneration?
Vitamin K epoxide reductase (VKOR)
CYP enzyme for S-warfarin metabolism?
CYP enzyme for S-warfarin metabolism?
CYP2C9
Warfarin's main action?
Warfarin's main action?
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Major phenindione side effect?
Major phenindione side effect?
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Clotting factor with longest half-life?
Clotting factor with longest half-life?
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Best test for oral anticoagulant monitoring?
Best test for oral anticoagulant monitoring?
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Warfarin overdose antidote?
Warfarin overdose antidote?
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Which clotting factors are affected by warfarin?
Which clotting factors are affected by warfarin?
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Warfarin's pregnancy contraindication?
Warfarin's pregnancy contraindication?
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