Podcast
Questions and Answers
Which adverse effect is NOT associated with carmustine?
Which adverse effect is NOT associated with carmustine?
- Nausea and vomiting
- Neurotoxicity (correct)
- Facial flushing
- Hepatotoxicity
What is the primary route of administration for lomustine?
What is the primary route of administration for lomustine?
- Intramuscular
- Subcutaneous
- Oral (correct)
- Intravenous
What is the main mechanism of action of alkylating agents like carmustine and lomustine?
What is the main mechanism of action of alkylating agents like carmustine and lomustine?
- Inhibiting cell membrane formation
- Inhibiting protein synthesis
- Inhibiting cell division
- Inhibiting DNA synthesis (correct)
Which adverse effect is common to both carmustine and lomustine?
Which adverse effect is common to both carmustine and lomustine?
What is the primary route of excretion for nitrosoureas like lomustine?
What is the primary route of excretion for nitrosoureas like lomustine?
Which of the following is a common adverse effect of nitrosoureas like carmustine and lomustine?
Which of the following is a common adverse effect of nitrosoureas like carmustine and lomustine?
What is the primary mechanism of action of nitrosoureas like streptozocin?
What is the primary mechanism of action of nitrosoureas like streptozocin?
Which type of cancer is lomustine commonly used to treat?
Which type of cancer is lomustine commonly used to treat?
What is the primary route of administration for platinum coordination complexes like cisplatin and carboplatin?
What is the primary route of administration for platinum coordination complexes like cisplatin and carboplatin?
How are platinum coordination complexes excreted from the body?
How are platinum coordination complexes excreted from the body?
Which of the following is NOT a route of administration for oxaliplatin?
Which of the following is NOT a route of administration for oxaliplatin?
In what manner are platinum coordination complexes like cisplatin and carboplatin commonly used?
In what manner are platinum coordination complexes like cisplatin and carboplatin commonly used?
Which type of cancer is commonly treated with oxaliplatin?
Which type of cancer is commonly treated with oxaliplatin?
When is carboplatin preferred over cisplatin?
When is carboplatin preferred over cisplatin?
For which type of cancer is cisplatin commonly used?
For which type of cancer is cisplatin commonly used?
What is a significant consideration when using carboplatin?
What is a significant consideration when using carboplatin?
Carboplatin can be used when the patient has kidney dysfunction or is prone to neuro or ototoxicity.
Carboplatin can be used when the patient has kidney dysfunction or is prone to neuro or ototoxicity.
Oxaliplatin is commonly used to treat colorectal cancer.
Oxaliplatin is commonly used to treat colorectal cancer.
Cisplatin is commonly used for the treatment of non-small cell lung cancer.
Cisplatin is commonly used for the treatment of non-small cell lung cancer.
Platinum coordination complexes are commonly used in the treatment of hematologic malignancies.
Platinum coordination complexes are commonly used in the treatment of hematologic malignancies.
Which platinum coordination complex is primarily associated with neurotoxicity?
Which platinum coordination complex is primarily associated with neurotoxicity?
What is the most common adverse effect of oxaliplatin?
What is the most common adverse effect of oxaliplatin?
Which platinum coordination complex is known for causing mild gastrointestinal toxicity?
Which platinum coordination complex is known for causing mild gastrointestinal toxicity?
What is the primary adverse effect of carboplatin?
What is the primary adverse effect of carboplatin?
Which type of drugs affect the equilibrium between polymerized and depolymerized forms of microtubules?
Which type of drugs affect the equilibrium between polymerized and depolymerized forms of microtubules?
In the treatment of which cancer type is cisplatin commonly used?
In the treatment of which cancer type is cisplatin commonly used?
What is the primary route of administration for vinca alkaloids and taxane family drugs?
What is the primary route of administration for vinca alkaloids and taxane family drugs?
Which platinum coordination complex is primarily associated with neurotoxicity?
Which platinum coordination complex is primarily associated with neurotoxicity?
What is the primary route of metabolism for vinca alkaloids?
What is the primary route of metabolism for vinca alkaloids?
Which adverse effect is commonly associated with vinca alkaloids?
Which adverse effect is commonly associated with vinca alkaloids?
What is the mode of action of vinca alkaloids?
What is the mode of action of vinca alkaloids?
Which platinum coordination complex is known for causing mild gastrointestinal toxicity?
Which platinum coordination complex is known for causing mild gastrointestinal toxicity?
What adverse effect is commonly associated with Vincristine (VCR)?
What adverse effect is commonly associated with Vincristine (VCR)?
Which cancer type is Vinorelbine (VRB) commonly used to treat?
Which cancer type is Vinorelbine (VRB) commonly used to treat?
What is the main use of Vinblastine (VBL)?
What is the main use of Vinblastine (VBL)?
What is the primary adverse effect of Vinca alkaloids?
What is the primary adverse effect of Vinca alkaloids?
What is the primary mechanism of action of Taxane family drugs like paclitaxel and docetaxel?
What is the primary mechanism of action of Taxane family drugs like paclitaxel and docetaxel?
What is the primary route of metabolism for Taxane family drugs like paclitaxel and docetaxel?
What is the primary route of metabolism for Taxane family drugs like paclitaxel and docetaxel?
Which adverse effect is commonly associated with Taxane family drugs like paclitaxel and docetaxel?
Which adverse effect is commonly associated with Taxane family drugs like paclitaxel and docetaxel?
When administering paclitaxel, what is the recommended action to prevent hypersensitivity reactions?
When administering paclitaxel, what is the recommended action to prevent hypersensitivity reactions?
What is the mechanism of action of camptothecins like irinotecan and topotecan?
What is the mechanism of action of camptothecins like irinotecan and topotecan?
What is the active metabolite of irinotecan, which is 1000 times more potent than irinotecan itself?
What is the active metabolite of irinotecan, which is 1000 times more potent than irinotecan itself?
In which condition is topotecan commonly used?
In which condition is topotecan commonly used?
For which cancer type is irinotecan commonly used in combination with 5-FU and leucovorin?
For which cancer type is irinotecan commonly used in combination with 5-FU and leucovorin?
What is the primary adverse effect associated with irinotecan?
What is the primary adverse effect associated with irinotecan?
Which adverse effect is primarily associated with topotecan?
Which adverse effect is primarily associated with topotecan?
Which side effect is most commonly associated with camptothecins as a class?
Which side effect is most commonly associated with camptothecins as a class?
Which adverse effect is NOT commonly associated with camptothecins?
Which adverse effect is NOT commonly associated with camptothecins?
What is the primary mode of action of etoposide?
What is the primary mode of action of etoposide?
Which adverse effect is commonly associated with camptothecins like irinotecan and topotecan?
Which adverse effect is commonly associated with camptothecins like irinotecan and topotecan?
In which phase of the cell cycle do camptothecins like irinotecan and topotecan specifically block cells?
In which phase of the cell cycle do camptothecins like irinotecan and topotecan specifically block cells?
What is the most common route of administration for etoposide?
What is the most common route of administration for etoposide?
Which type of tumors may be hormone responsive, hormone dependent, or both?
Which type of tumors may be hormone responsive, hormone dependent, or both?
What is the primary mode of action of selective estrogen modulator (SERM)?
What is the primary mode of action of selective estrogen modulator (SERM)?
Which agents are used to treat hormone dependent tumors?
Which agents are used to treat hormone dependent tumors?
What is the primary function of antiandrogens in the treatment of tumors?
What is the primary function of antiandrogens in the treatment of tumors?
What is the first-line therapy for estrogen receptor-positive breast cancer and the prevention of breast cancer in high-risk women?
What is the first-line therapy for estrogen receptor-positive breast cancer and the prevention of breast cancer in high-risk women?
What is the primary route of metabolism for tamoxifen?
What is the primary route of metabolism for tamoxifen?
Which enzyme does tamoxifen inhibit, leading to potential drug-drug interactions?
Which enzyme does tamoxifen inhibit, leading to potential drug-drug interactions?
What are some of the adverse effects associated with tamoxifen?
What are some of the adverse effects associated with tamoxifen?
Tamoxifen acts as an estrogen antagonist in breast tissue and an agonist in bone and endometrium.
Tamoxifen acts as an estrogen antagonist in breast tissue and an agonist in bone and endometrium.
Tamoxifen is primarily metabolized in the kidneys.
Tamoxifen is primarily metabolized in the kidneys.
Tamoxifen is associated with adverse effects such as hot flashes and thromboembolism.
Tamoxifen is associated with adverse effects such as hot flashes and thromboembolism.
Tamoxifen is the first-line therapy for progesterone receptor-positive breast cancer.
Tamoxifen is the first-line therapy for progesterone receptor-positive breast cancer.
