Antibody Structure and Specificity Quiz
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Questions and Answers

What defines different Ig classes within a species?

  • Very minor differences in H chain aa sequence
  • Differences in Fc region
  • Major differences in H-chain aa sequence (correct)
  • Minor differences in Fab V regions
  • Which Immunoglobulin class has a molecular weight (MW) of 950,000 and is effective at agglutination?

  • IgG
  • IgM (correct)
  • SIgA
  • IgA
  • Can different isotypes have the same idiotype?

  • Yes, sometimes (correct)
  • Yes, always
  • No, never
  • Only in the Fc region
  • Why were Allotypes important in forensic medicine?

    <p>For identifying individuals based on immune markers</p> Signup and view all the answers

    Which Immunoglobulin class can cross the placenta from mother to fetus?

    <p>IgG</p> Signup and view all the answers

    What part of the Syncytiotrophoblast is responsible for the transport of IgG across the placenta?

    <p>Epithelial covering</p> Signup and view all the answers

    Which type of Immunoglobulin is mainly found in the serum and tissues?

    <p>IgG</p> Signup and view all the answers

    Which Immunoglobulin is the largest in size and the first to be produced during an immune response?

    <p>IgM</p> Signup and view all the answers

    Which Immunoglobulin class is primarily involved in mucosal immunity and present in secretions like tears and saliva?

    <p>IgA</p> Signup and view all the answers

    Which Immunoglobulin class is associated with allergic reactions and defense against parasitic infections?

    <p>IgE</p> Signup and view all the answers

    Which term refers to the distinct antigenic determinants found on the variable regions of antibodies?

    <p>Idiotype</p> Signup and view all the answers

    Where is most of the specificity for antigen binding found?

    <p>HVR</p> Signup and view all the answers

    How many subclasses of IgG exist?

    <p>4</p> Signup and view all the answers

    Which type of Immunoglobulin is responsible for allergic reactions?

    <p>IgE</p> Signup and view all the answers

    What term describes variations between individuals of the same species in the C-region of an Ig isotype?

    <p>Allotypes</p> Signup and view all the answers

    Which term describes the unique antigen binding region of an antibody formed by the L- and H-chain V-regions?

    <p>Idiotypes</p> Signup and view all the answers

    How do most IgG C-region amino acid sequences differ among individuals within a species?

    <p>They are identical (Iso)</p> Signup and view all the answers

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