17 Questions
What defines different Ig classes within a species?
Major differences in H-chain aa sequence
Which Immunoglobulin class has a molecular weight (MW) of 950,000 and is effective at agglutination?
IgM
Can different isotypes have the same idiotype?
Yes, sometimes
Why were Allotypes important in forensic medicine?
For identifying individuals based on immune markers
Which Immunoglobulin class can cross the placenta from mother to fetus?
IgG
What part of the Syncytiotrophoblast is responsible for the transport of IgG across the placenta?
Epithelial covering
Which type of Immunoglobulin is mainly found in the serum and tissues?
IgG
Which Immunoglobulin is the largest in size and the first to be produced during an immune response?
IgM
Which Immunoglobulin class is primarily involved in mucosal immunity and present in secretions like tears and saliva?
IgA
Which Immunoglobulin class is associated with allergic reactions and defense against parasitic infections?
IgE
Which term refers to the distinct antigenic determinants found on the variable regions of antibodies?
Idiotype
Where is most of the specificity for antigen binding found?
HVR
How many subclasses of IgG exist?
4
Which type of Immunoglobulin is responsible for allergic reactions?
IgE
What term describes variations between individuals of the same species in the C-region of an Ig isotype?
Allotypes
Which term describes the unique antigen binding region of an antibody formed by the L- and H-chain V-regions?
Idiotypes
How do most IgG C-region amino acid sequences differ among individuals within a species?
They are identical (Iso)
Test your knowledge on the structure and specificity of antibodies, focusing on heterogenicity, hypervariable regions, globular protein structure, and isotypes. Learn about the key components involved in antigen binding and the differences in H-chain isotypes.
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