Podcast
Questions and Answers
Which of the following is NOT a method of antibacterial susceptibility testing?
Which of the following is NOT a method of antibacterial susceptibility testing?
- Broad-spectrum antibiotics include (correct)
- Automated method
- Diffusion method
- Dilution method
Which of the following lists contains only broad-spectrum antibiotics?
Which of the following lists contains only broad-spectrum antibiotics?
- Tetracycline, meropenem, penicillin G (correct)
- Ceftriaxone, imipenem, ciprofloxacin
- Vancomycin, penicillin G, imipenem
- Vancomycin, cefepime, imipenem
Which cephalosporin is a first-generation cephalosporin?
Which cephalosporin is a first-generation cephalosporin?
- Cefepime
- Cefuroxime
- Cefazolin (correct)
- Ceftriaxone
Which beta-lactam and beta-lactamase inhibitor combination is NOT typically used in treatment?
Which beta-lactam and beta-lactamase inhibitor combination is NOT typically used in treatment?
Which antibiotic inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala?
Which antibiotic inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala?
Which antibiotic's mode of action is the inhibition of protein synthesis?
Which antibiotic's mode of action is the inhibition of protein synthesis?
Which antibiotic interferes with cell membrane integrity, leading to cell damage?
Which antibiotic interferes with cell membrane integrity, leading to cell damage?
Which pair of antibiotics contains an antibiotic that is NOT a tetracycline?
Which pair of antibiotics contains an antibiotic that is NOT a tetracycline?
In susceptibility testing, what does 'susceptible, increased exposure' mean?
In susceptibility testing, what does 'susceptible, increased exposure' mean?
What does the abbreviation MBC stand for?
What does the abbreviation MBC stand for?
Flashcards
Antibacterial Susceptibility Testing Methods
Antibacterial Susceptibility Testing Methods
Testing a bacteria's vulnerability to antibiotics using dilution, diffusion, or automation.
Broad-spectrum antibiotics
Broad-spectrum antibiotics
Antibiotics effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. Examples include tetracycline, meropenem, and penicillin G.
Cefazolin
Cefazolin
A first-generation cephalosporin antibiotic used to treat bacterial infections.
Vancomycin
Vancomycin
Inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala, preventing peptidoglycan formation.
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Amikacin
Amikacin
Targets bacterial ribosomes, disrupting the synthesis of proteins.
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Colistin
Colistin
Damages bacterial cell membranes, leading to increased permeability and cell death.
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Susceptible, Increased Exposure
Susceptible, Increased Exposure
A parameter in susceptibility testing that means therapeutic success is likely due to increased drug exposure via adjusted dosing.
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MBC Meaning
MBC Meaning
The lowest concentration of an antibacterial agent required to kill a particular bacterium.
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- Broad-spectrum antibiotics is not a method of antibacterial susceptibility testing; methods include dilution, diffusion, and automated methods.
- Broad-spectrum antibiotics include tetracycline, meropenem, and penicillin G.
Cephalosporins
- Cefazolin is a first-generation cephalosporin.
Beta-Lactam Combinations
- Cefotaxime-tazobactam is NOT a beta-lactam/beta-lactamase inhibitor combination used in treatment; other combinations used in treatments include:
- Piperacillin-tazobactam
- Ampicillin-sulbactam
- Amoxicillin-clavulanate
- Ceftazidime-avibactam
Mechanism of Action
- Vancomycin inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala.
- Amikacin inhibits protein synthesis.
- Colistin interferes with cell membrane integrity, leading to cell damage.
Antibiotic Classes
- Tigecycline is not a tetracycline; doxycycline is a tetracycline.
Susceptibility Testing
- 'Susceptible, increased exposure' indicates a high likelihood of therapeutic success when exposure to the agent is increased by adjusting the dosing regimen or by its concentration at the site of infection.
Abbreviations
- MBC stands for minimal bactericidal concentration.
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