Questions and Answers
What drug class is Imipenem/Cilastatin?
What is the mechanism of action of Imipenem/Cilastatin?
Binding to bacterial cell wall, resulting in cell death.
What are the indications for Imipenem/Cilastatin?
Bacterial infections (bone, joint, and skin).
What are the contraindications for Imipenem/Cilastatin?
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How is Imipenem/Cilastatin administered?
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How is Imipenem/Cilastatin metabolized?
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How is Imipenem/Cilastatin excreted?
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What are the common side effects of Imipenem/Cilastatin?
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What are some adverse effects of Imipenem/Cilastatin?
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What drug interaction should be avoided with Imipenem/Cilastatin?
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What are the nursing implications for Imipenem/Cilastatin?
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Study Notes
Imipenem/Cilastatin Overview
- Classified as a carbapenem antibiotic used to treat various bacterial infections.
Mechanism of Action
- Functions by binding to the bacterial cell wall, leading to cell death, characterized as bactericidal.
Indications
- Prescribed for bacterial infections, particularly involving bones, joints, and skin.
Contraindications
- Not suitable for individuals with a known allergy to lidocaine.
Administration
- Administered via intravenous (IV) or intramuscular (IM) injection.
Pharmacokinetics
- Approximately 70% of the drug is metabolized by the kidneys.
- Excretion occurs primarily through the urine via the kidneys.
Side Effects
- Common side effects include seizures (more frequent in older adults), dizziness, and hypotension.
Adverse Effects
- Serious adverse effects can include:
- Seizures
- Dizziness
- Somnolence
- Hypotension
- Risk of C. difficile infection
- Skin reactions such as rash, pruritus, sweating, and urticaria.
Drug Interactions
- Should not be mixed with aminoglycosides.
- Probenecid can reduce renal excretion, causing increased blood levels of the drug.
Nursing Implications
- A thorough health history must be obtained before starting therapy.
- Regular assessment of infection signs, including monitoring of vital signs, is essential.
- Be vigilant for signs of anaphylaxis during treatment.
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Test your knowledge on Imipenem/Cilastatin with these flashcards. Learn about its drug class, mechanism of action, indications, and contraindications. Perfect for students and healthcare professionals alike.
