Podcast
Questions and Answers
What is a key reason for infectious diseases that were once considered incurable becoming curable?
What is a key reason for infectious diseases that were once considered incurable becoming curable?
- Inhibition of viral replication
- Inhibition of bacterial ribosomes (correct)
- Inhibition of fungal cell wall synthesis
- Inhibition of eukaryotic DNA synthesis
Which region had the highest death rate associated with Antibiotic Resistance in 2019 according to the text?
Which region had the highest death rate associated with Antibiotic Resistance in 2019 according to the text?
- Western sub-Saharan Africa (correct)
- Western Europe
- North America
- Australia
Which of the following is not one of the six leading pathogens mentioned in the text?
Which of the following is not one of the six leading pathogens mentioned in the text?
- Klebsiella pneumoniae
- Acinetobacter baumannii
- Streptococcus pyogenes (correct)
- Escherichia coli
Which antibiotic was mentioned as the most prescribed in the community in 2021?
Which antibiotic was mentioned as the most prescribed in the community in 2021?
How many unnecessary antibiotic prescriptions were estimated to have been given in 2021?
How many unnecessary antibiotic prescriptions were estimated to have been given in 2021?
What amount was spent on treating the six leading infections in 2021 according to Nelson et al.?
What amount was spent on treating the six leading infections in 2021 according to Nelson et al.?
What is the main difference between static and cidal antimicrobial activity?
What is the main difference between static and cidal antimicrobial activity?
Which type of drug absorption is influenced by factors such as chemistry and intestinal transit time?
Which type of drug absorption is influenced by factors such as chemistry and intestinal transit time?
Which body organ is primarily responsible for the excretion of drugs like penicillin, vancomycin, and cephalosporins?
Which body organ is primarily responsible for the excretion of drugs like penicillin, vancomycin, and cephalosporins?
What principle of pharmacokinetics explains the phenomenon of competing similar molecules delaying drug elimination?
What principle of pharmacokinetics explains the phenomenon of competing similar molecules delaying drug elimination?
In the context of antimicrobials, what does MIC stand for?
In the context of antimicrobials, what does MIC stand for?
Which type of antimicrobial activity results in continuing antibacterial effects even after drug removal?
Which type of antimicrobial activity results in continuing antibacterial effects even after drug removal?
What is the primary function of pharmacodynamics in the context of antimicrobials?
What is the primary function of pharmacodynamics in the context of antimicrobials?
Which factor influences the amount absorbed in oral doses?
Which factor influences the amount absorbed in oral doses?
Which type of absorption method results in poor penetration into eyes, prostate, and CNS for penicillin?
Which type of absorption method results in poor penetration into eyes, prostate, and CNS for penicillin?
What is the influence of protein binding on drug interactions according to pharmacokinetics?
What is the influence of protein binding on drug interactions according to pharmacokinetics?
Which of the following is considered a concerning threat according to the text?
Which of the following is considered a concerning threat according to the text?
What is one of the sources for antibacterials mentioned in the text?
What is one of the sources for antibacterials mentioned in the text?
Which pathogen has the potential to be treated by 19 of the antibacterial agents mentioned in the text?
Which pathogen has the potential to be treated by 19 of the antibacterial agents mentioned in the text?
What do companies need in terms of return to invest in a new drug?
What do companies need in terms of return to invest in a new drug?
Which phase includes small clinical trials in humans to collect initial data on efficacy and safety?
Which phase includes small clinical trials in humans to collect initial data on efficacy and safety?
What is the concern regarding antibiotic development costs according to the text?
What is the concern regarding antibiotic development costs according to the text?
Which issue does One Health emphasize according to the text?
Which issue does One Health emphasize according to the text?
What global issue facilitates the worldwide spread of antimicrobial resistance that occurs locally?
What global issue facilitates the worldwide spread of antimicrobial resistance that occurs locally?
Which bacterial pathogen resistant to antibiotic drugs is threatening our ability to treat patients according to the text?
Which bacterial pathogen resistant to antibiotic drugs is threatening our ability to treat patients according to the text?
What is the purpose of Investigational New Drug Application (IND) mentioned in the text?
What is the purpose of Investigational New Drug Application (IND) mentioned in the text?
What is the gold standard for evaluating pharmacokinetic/pharmacodynamic antibiotics?
What is the gold standard for evaluating pharmacokinetic/pharmacodynamic antibiotics?
Which of the following PK/PD indices represents the cumulative percentage of a 24-hour period that the antibiotic concentration is above the MIC?
Which of the following PK/PD indices represents the cumulative percentage of a 24-hour period that the antibiotic concentration is above the MIC?
What parameter is used to classify if a drug is bacteriostatic or bactericidal?
What parameter is used to classify if a drug is bacteriostatic or bactericidal?
Which drug class is associated with a high post-antibiotic effect (PAE)?
Which drug class is associated with a high post-antibiotic effect (PAE)?
What is the purpose of Monte Carlo Simulation in pharmacodynamics studies?
What is the purpose of Monte Carlo Simulation in pharmacodynamics studies?
Which pharmacodynamic parameter involves the area under the concentration-time curve of an antibiotic?
Which pharmacodynamic parameter involves the area under the concentration-time curve of an antibiotic?
What is the Post-Antibiotic Effect (PAE) defined as?
What is the Post-Antibiotic Effect (PAE) defined as?
Which factor does NOT influence the Post-Antibiotic Effect (PAE) according to the text?
Which factor does NOT influence the Post-Antibiotic Effect (PAE) according to the text?
Which type of antibiotics display prolonged Post-Antibiotic Effect (PAE) against susceptible organisms?
Which type of antibiotics display prolonged Post-Antibiotic Effect (PAE) against susceptible organisms?
What do Clinical Breakpoints help determine in relation to antibiotic therapy?
What do Clinical Breakpoints help determine in relation to antibiotic therapy?
What is the primary challenge highlighted in the text regarding Gram-negative resistance?
What is the primary challenge highlighted in the text regarding Gram-negative resistance?
What is recommended by the CDC for all hospitals in response to antibiotic stewardship?
What is recommended by the CDC for all hospitals in response to antibiotic stewardship?
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