Antibacterials I Introduction to Antimicrobial Chemotherapy
38 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a key reason for infectious diseases that were once considered incurable becoming curable?

  • Inhibition of viral replication
  • Inhibition of bacterial ribosomes (correct)
  • Inhibition of fungal cell wall synthesis
  • Inhibition of eukaryotic DNA synthesis
  • Which region had the highest death rate associated with Antibiotic Resistance in 2019 according to the text?

  • Western sub-Saharan Africa (correct)
  • Western Europe
  • North America
  • Australia
  • Which of the following is not one of the six leading pathogens mentioned in the text?

  • Klebsiella pneumoniae
  • Acinetobacter baumannii
  • Streptococcus pyogenes (correct)
  • Escherichia coli
  • Which antibiotic was mentioned as the most prescribed in the community in 2021?

    <p>Amoxicillin</p> Signup and view all the answers

    How many unnecessary antibiotic prescriptions were estimated to have been given in 2021?

    <p>~20 million</p> Signup and view all the answers

    What amount was spent on treating the six leading infections in 2021 according to Nelson et al.?

    <p>$4.6 billion</p> Signup and view all the answers

    What is the main difference between static and cidal antimicrobial activity?

    <p>Static activity causes irreversible loss of ability to reproduce, while cidal activity causes reversible loss of ability to reproduce.</p> Signup and view all the answers

    Which type of drug absorption is influenced by factors such as chemistry and intestinal transit time?

    <p>Oral absorption</p> Signup and view all the answers

    Which body organ is primarily responsible for the excretion of drugs like penicillin, vancomycin, and cephalosporins?

    <p>Kidneys</p> Signup and view all the answers

    What principle of pharmacokinetics explains the phenomenon of competing similar molecules delaying drug elimination?

    <p>Excretion principle</p> Signup and view all the answers

    In the context of antimicrobials, what does MIC stand for?

    <p>Minimal Inhibitory Concentration</p> Signup and view all the answers

    Which type of antimicrobial activity results in continuing antibacterial effects even after drug removal?

    <p>Post-Antibiotic Effect</p> Signup and view all the answers

    What is the primary function of pharmacodynamics in the context of antimicrobials?

    <p>Interaction of drug with target bacterium</p> Signup and view all the answers

    Which factor influences the amount absorbed in oral doses?

    <p>Intestinal transit time</p> Signup and view all the answers

    Which type of absorption method results in poor penetration into eyes, prostate, and CNS for penicillin?

    <p>Oral absorption</p> Signup and view all the answers

    What is the influence of protein binding on drug interactions according to pharmacokinetics?

    <p>Only drugs free from protein binding can interact with pathogens</p> Signup and view all the answers

    Which of the following is considered a concerning threat according to the text?

    <p>Erythromycin-resistant Group A Streptococcus</p> Signup and view all the answers

    What is one of the sources for antibacterials mentioned in the text?

    <p>Semi-synthetic</p> Signup and view all the answers

    Which pathogen has the potential to be treated by 19 of the antibacterial agents mentioned in the text?

    <p>Multidrug-resistant Pseudomonas aeruginosa</p> Signup and view all the answers

    What do companies need in terms of return to invest in a new drug?

    <p>$200 million a year</p> Signup and view all the answers

    Which phase includes small clinical trials in humans to collect initial data on efficacy and safety?

    <p>Phase I</p> Signup and view all the answers

    What is the concern regarding antibiotic development costs according to the text?

    <p>$65 million is not enough return for companies investing in antibiotics</p> Signup and view all the answers

    Which issue does One Health emphasize according to the text?

    <p>Health linkages among humans, animals, and the environment</p> Signup and view all the answers

    What global issue facilitates the worldwide spread of antimicrobial resistance that occurs locally?

    <p>Global travel</p> Signup and view all the answers

    Which bacterial pathogen resistant to antibiotic drugs is threatening our ability to treat patients according to the text?

    <p>Methicillin-resistant Staphylococcus aureus (MRSA)</p> Signup and view all the answers

    What is the purpose of Investigational New Drug Application (IND) mentioned in the text?

    <p>Approval prior to clinical trials to ensure safety</p> Signup and view all the answers

    What is the gold standard for evaluating pharmacokinetic/pharmacodynamic antibiotics?

    <p>AUC/MIC</p> Signup and view all the answers

    Which of the following PK/PD indices represents the cumulative percentage of a 24-hour period that the antibiotic concentration is above the MIC?

    <p>T&gt;MIC</p> Signup and view all the answers

    What parameter is used to classify if a drug is bacteriostatic or bactericidal?

    <p>MIC value</p> Signup and view all the answers

    Which drug class is associated with a high post-antibiotic effect (PAE)?

    <p>Aminoglycosides</p> Signup and view all the answers

    What is the purpose of Monte Carlo Simulation in pharmacodynamics studies?

    <p>To generate random PK and MIC values</p> Signup and view all the answers

    Which pharmacodynamic parameter involves the area under the concentration-time curve of an antibiotic?

    <p>AUC/MIC</p> Signup and view all the answers

    What is the Post-Antibiotic Effect (PAE) defined as?

    <p>Continued activity of antibiotic after it is removed</p> Signup and view all the answers

    Which factor does NOT influence the Post-Antibiotic Effect (PAE) according to the text?

    <p>Presence of host response</p> Signup and view all the answers

    Which type of antibiotics display prolonged Post-Antibiotic Effect (PAE) against susceptible organisms?

    <p>Nucleic acid synthesis inhibitors</p> Signup and view all the answers

    What do Clinical Breakpoints help determine in relation to antibiotic therapy?

    <p>The probability of a cure based on dosing regimen</p> Signup and view all the answers

    What is the primary challenge highlighted in the text regarding Gram-negative resistance?

    <p>Diminished antibiotic discovery programs</p> Signup and view all the answers

    What is recommended by the CDC for all hospitals in response to antibiotic stewardship?

    <p>Implementation of Infection Control programs</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Browser