Anti-Tuberculous Agents Overview

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which anti-tuberculous agent primarily disrupts cell wall synthesis?

Rifampin
Ethambutol
Isoniazid (correct)
Cycloserine

What is the main action of Rifampin in treating tuberculosis?

Inhibition of DNA replication
Disruption of fatty acid synthesis
Prevention of RNA synthesis (correct)
Inhibition of protein synthesis

Which agent alters phosphate metabolism as part of its mechanism of action?

Ethambutol (correct)
Rifampin
Isoniazid
Streptomycin

What is a secondary effect of Isoniazid's mechanism in mycobacteria?

<p>Inhibition of cell replication (B)</p> Signup and view all the answers

Which of the following actions is NOT associated with Ethambutol?

<p>Prevents RNA synthesis (D)</p> Signup and view all the answers

Flashcards

What is the mechanism of action of Ethambutol?

Ethambutol works by interfering with the production of cellular RNA and disrupting phosphate metabolism.

How does Isoniazid work against tuberculosis?

Isoniazid disrupts the formation of the mycobacterial cell wall and hinders its replication.

What is the primary mechanism of action for Rifampin?

Rifampin blocks the production of RNA by inhibiting the bacterial enzyme responsible for RNA synthesis, DNA-dependent RNA polymerase. This halts important metabolic pathways essential for the bacterium's growth and replication.

How does Ethambutol affect mycobacterial growth?

Ethambutol disrupts the mycobacteria's ability to produce RNA and utilize phosphate, leading to a weakened cell and inhibiting its growth.

Signup and view all the flashcards

What is the target of Rifampin action in tuberculosis?

Rifampin blocks the bacterial enzyme DNA-dependent RNA polymerase, which hinders RNA synthesis. This prevents the bacteria from carrying out essential metabolic processes for growth and replication.

Signup and view all the flashcards

Study Notes

Anti-Tuberculous Agents

Ethambutol: Disrupts cellular RNA synthesis and phosphate metabolism.
Isoniazid: Damages the cell wall and inhibits bacterial replication.
Rifampin: Inhibits RNA synthesis by targeting DNA-dependent RNA polymerase, which stops key metabolic pathways needed by mycobacteria to grow and reproduce.