Anti-Dyslipidemic Drugs Classification Quiz
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Questions and Answers

What is the mechanism of action of fibrates in hypertriglyceridemia?

  • Activates lipoprotein lipase
  • Possess a weak PPAR-α agonistic effect (correct)
  • Inhibits hormone sensitive lipase
  • Inhibits TXA2 synthesis
  • Which of the following statements about Omega-3 Fatty Acids is true?

  • Increase lipolysis in adipose tissue
  • Inhibit platelet aggregation (correct)
  • Decrease serum uric acid levels
  • Act as adjuvant therapy in hypercholesterolemia
  • How does Niacin act to modulate lipid profile?

  • Decreases VLDL circulatory clearance
  • Increases Apo A clearance from plasma (correct)
  • Inhibits lipoprotein lipase
  • Activates hormone sensitive lipase
  • Why is it cautioned to use fibrates in renal and hepatic impairments?

    <p>Possible exacerbation of hepatic or renal dysfunction</p> Signup and view all the answers

    Which agent is NOT recommended during pregnancy?

    <p>Fibrates</p> Signup and view all the answers

    Which of the following is a key feature of lipophilic statins compared to hydrophilic statins?

    <p>Metabolized by the liver and have many drug interactions</p> Signup and view all the answers

    How do statins primarily modulate the lipid profile?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a potential adverse effect of lipophilic statins?

    <p>Dose-dependent elevation in hepatic enzymes</p> Signup and view all the answers

    In which of the following conditions are statins particularly useful as anti-hypercholesterolemic agents?

    <p>Dyslipidemia, especially hypercholesterolemia</p> Signup and view all the answers

    How do statins help in the treatment of mixed dyslipidemias?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is the drug of choice for managing hypertriglyceridemia in diabetic patients?

    <p>Fibrates</p> Signup and view all the answers

    Which of the following statements about ezetimibe is correct?

    <p>It selectively inhibits the Niemann-Pick C1-Like 1 (NPC1L1) transporter, reducing exogenous cholesterol absorption.</p> Signup and view all the answers

    Which of the following is a potential benefit of using statins during or following an ischemic event, such as a myocardial infarction or stroke?

    <p>Reducing the risk of recurrent ischemic events by lowering LDL-C levels.</p> Signup and view all the answers

    Which of the following is a potential mechanism by which fibrates modulate lipid metabolism?

    <p>Increasing the expression of lipoprotein lipase and enzymes involved in fatty acid oxidation.</p> Signup and view all the answers

    According to the provided information, which of the following statements about the use of statins is correct?

    <p>Statins are lipid-lowering agents that inhibit the rate-limiting enzyme in cholesterol biosynthesis.</p> Signup and view all the answers

    What is the primary mechanism of action of statins?

    <p>Reversibly inhibiting HMG-COA Reductase Enzyme</p> Signup and view all the answers

    Which group of anti-dyslipidemic agents is specifically effective in reducing hypertriglyceridemia?

    <p>Fibrates (PPAR-α)</p> Signup and view all the answers

    How do statins reduce blood cholesterol levels?

    <p>Upregulating LDL-Receptors to uptake circulating cholesterol</p> Signup and view all the answers

    In dyslipidemia with hypertriglyceridemia, which combination of drugs is most appropriate for treatment?

    <p>Ezetimibe and fibrates</p> Signup and view all the answers

    Which anti-dyslipidemic agent is particularly effective in managing mixed dyslipidemia?

    <p>Niacin</p> Signup and view all the answers

    Which of the following is a major mechanism of action for cholestyramine in lowering cholesterol levels?

    <p>Stimulating LDL receptor expression on hepatocytes</p> Signup and view all the answers

    Which of the following adverse effects is associated with the use of niacin as a lipid-lowering agent?

    <p>Flushing and pruritus</p> Signup and view all the answers

    Which of the following statements regarding the use of niacin in diabetic patients is correct?

    <p>Niacin should be used cautiously in diabetic patients, as it may elevate blood glucose levels.</p> Signup and view all the answers

    Which of the following is a potential concern when using cholestyramine in combination with other medications?

    <p>Adsorption and decreased absorption of fat-soluble vitamins and drugs</p> Signup and view all the answers

    Which of the following statements about the use of lipid-lowering agents in ischemic insults is correct?

    <p>Aggressive lipid management with agents like statins and fibrates is recommended in patients with ischemic insults to reduce the risk of recurrent events.</p> Signup and view all the answers

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