Anti-Dyslipidemic Drugs Classification Quiz

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What is the mechanism of action of fibrates in hypertriglyceridemia?

Activates lipoprotein lipase
Possess a weak PPAR-α agonistic effect (correct)
Inhibits hormone sensitive lipase
Inhibits TXA2 synthesis

Which of the following statements about Omega-3 Fatty Acids is true?

Increase lipolysis in adipose tissue
Inhibit platelet aggregation (correct)
Decrease serum uric acid levels
Act as adjuvant therapy in hypercholesterolemia

How does Niacin act to modulate lipid profile?

Decreases VLDL circulatory clearance
Increases Apo A clearance from plasma (correct)
Inhibits lipoprotein lipase
Activates hormone sensitive lipase

Why is it cautioned to use fibrates in renal and hepatic impairments?

Possible exacerbation of hepatic or renal dysfunction (B) Signup and view all the answers

Which agent is NOT recommended during pregnancy?

Fibrates (C) Signup and view all the answers

Which of the following is a key feature of lipophilic statins compared to hydrophilic statins?

Metabolized by the liver and have many drug interactions (B) Signup and view all the answers

How do statins primarily modulate the lipid profile?

All of the above (D) Signup and view all the answers

Which of the following is a potential adverse effect of lipophilic statins?

Dose-dependent elevation in hepatic enzymes (D) Signup and view all the answers

In which of the following conditions are statins particularly useful as anti-hypercholesterolemic agents?

Dyslipidemia, especially hypercholesterolemia (C) Signup and view all the answers

How do statins help in the treatment of mixed dyslipidemias?

All of the above (D) Signup and view all the answers

Which of the following is the drug of choice for managing hypertriglyceridemia in diabetic patients?

Fibrates (B) Signup and view all the answers

Which of the following statements about ezetimibe is correct?

It selectively inhibits the Niemann-Pick C1-Like 1 (NPC1L1) transporter, reducing exogenous cholesterol absorption. (B) Signup and view all the answers

Which of the following is a potential benefit of using statins during or following an ischemic event, such as a myocardial infarction or stroke?

Reducing the risk of recurrent ischemic events by lowering LDL-C levels. (C) Signup and view all the answers

Which of the following is a potential mechanism by which fibrates modulate lipid metabolism?

Increasing the expression of lipoprotein lipase and enzymes involved in fatty acid oxidation. (C) Signup and view all the answers

According to the provided information, which of the following statements about the use of statins is correct?

Statins are lipid-lowering agents that inhibit the rate-limiting enzyme in cholesterol biosynthesis. (C) Signup and view all the answers

What is the primary mechanism of action of statins?

Reversibly inhibiting HMG-COA Reductase Enzyme (C) Signup and view all the answers

Which group of anti-dyslipidemic agents is specifically effective in reducing hypertriglyceridemia?

Fibrates (PPAR-α) (A) Signup and view all the answers

How do statins reduce blood cholesterol levels?

Upregulating LDL-Receptors to uptake circulating cholesterol (D) Signup and view all the answers

In dyslipidemia with hypertriglyceridemia, which combination of drugs is most appropriate for treatment?

Ezetimibe and fibrates (C) Signup and view all the answers

Which anti-dyslipidemic agent is particularly effective in managing mixed dyslipidemia?

Niacin (C) Signup and view all the answers

Which of the following is a major mechanism of action for cholestyramine in lowering cholesterol levels?

Stimulating LDL receptor expression on hepatocytes (D) Signup and view all the answers

Which of the following adverse effects is associated with the use of niacin as a lipid-lowering agent?

Flushing and pruritus (C) Signup and view all the answers

Which of the following statements regarding the use of niacin in diabetic patients is correct?

Niacin should be used cautiously in diabetic patients, as it may elevate blood glucose levels. (C) Signup and view all the answers

Which of the following is a potential concern when using cholestyramine in combination with other medications?

Adsorption and decreased absorption of fat-soluble vitamins and drugs (A) Signup and view all the answers

Which of the following statements about the use of lipid-lowering agents in ischemic insults is correct?

Aggressive lipid management with agents like statins and fibrates is recommended in patients with ischemic insults to reduce the risk of recurrent events. (D) Signup and view all the answers