endocrine 3

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Questions and Answers

A patient presents with symptoms of Cushing's Syndrome. Which pituitary hormone is most likely responsible for this condition?

  • Adrenocorticotropic Hormone (ACTH) (correct)
  • Growth Hormone (GH)
  • Prolactin
  • Thyroid Stimulating Hormone (TSH)

Which of the following statements is TRUE about pituitary tumors (adenomas)?

  • They are always metastatic.
  • They always interfere with normal hormone production.
  • They can be classified as secretory or non-secretory. (correct)
  • They only affect women, as they are more prevalent.
  • All of the above

What is the primary difference between the anterior and posterior pituitary glands?

  • The anterior pituitary produces hormones, while the posterior pituitary only stores and releases them. (correct)
  • The anterior pituitary is controlled by the hypothalamus via neural input, while the posterior pituitary is controlled via the portal vasculature.
  • The anterior pituitary is derived from neural tissue, while the posterior pituitary is derived from ectoderm.
  • The anterior pituitary produces hormones that regulate other endocrine glands, while the posterior pituitary produces hormones that directly affect target tissues.

What is the role of the hypothalamus in regulating pituitary hormone secretion?

<p>The hypothalamus produces inhibiting factors that control the release of hormones from the anterior pituitary. (B), The hypothalamus produces stimulating factors that control the release of hormones from both the anterior and posterior pituitary. (C), The hypothalamus directly controls the release of hormones from the posterior pituitary. (D)</p> Signup and view all the answers

What is a possible consequence of hyposecretion of growth hormone (GH) in childhood?

<p>Dwarfism (C)</p> Signup and view all the answers

What is a primary cause of dwarfism related to growth hormone?

<p>Deficiency of growth hormone before bone growth plates close (D)</p> Signup and view all the answers

Which hormone is NOT disrupted in pituitary dwarfism in dogs?

<p>Adrenocorticotropic hormone (ACTH) (D)</p> Signup and view all the answers

Which condition is characterized by disproportionate growth?

<p>Acromegaly (B)</p> Signup and view all the answers

What is the function of growth hormone in the anterior pituitary?

<p>Promotes growth in bones, muscles, and the liver (C)</p> Signup and view all the answers

Which of the following is associated with congenital problems in pituitary gland development?

<p>Pituitary dwarfism in dogs (D)</p> Signup and view all the answers

What is one of the common clinical manifestations of pituitary dwarfism in dogs?

<p>Retention of secondary hairs and alopecia (A)</p> Signup and view all the answers

What are the two main families of hormones secreted by the anterior pituitary?

<p>Growth hormone family and prolactin family (C)</p> Signup and view all the answers

Which hormone stimulates milk production in mammals?

<p>Prolactin (B)</p> Signup and view all the answers

What condition is associated with high TSH and low T3/T4 levels?

<p>Hypothyroidism (Hashimoto’s Thyroidism) (A)</p> Signup and view all the answers

Which hormone is responsible for stimulating ovulation in females?

<p>Luteinizing Hormone (LH) (A)</p> Signup and view all the answers

What is the primary consequence of anterior pituitary gland dysfunction?

<p>Disruption of multiple hormonal pathways (A)</p> Signup and view all the answers

Which hormone(s) are primarily produced in the gonadotropes of the anterior pituitary?

<p>Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) (A)</p> Signup and view all the answers

Which of the following conditions is characterized by low TSH and low T3/T4?

<p>Hypothyroidism (B)</p> Signup and view all the answers

What is the effect of Follicle Stimulating Hormone (FSH) in males?

<p>Supporting spermatogenesis (C)</p> Signup and view all the answers

What condition is characterized by high T3/T4 and low TSH levels?

<p>Grave’s Disease (A)</p> Signup and view all the answers

Which of the following hormones is primarily associated with the regulation of stress response?

<p>Adrenocorticotropic Hormone (ACTH) (C)</p> Signup and view all the answers

Which of the following hormones is primarily responsible for milk production?

<p>Prolactin (PRL) (C)</p> Signup and view all the answers

What cell type produces Growth Hormone (GH) in the anterior pituitary?

<p>Somatotrope cells (B)</p> Signup and view all the answers

Thyroid Stimulating Hormone (TSH) primarily acts on which gland?

<p>Thyroid Gland (C)</p> Signup and view all the answers

Which of the following hormones is NOT produced by the anterior pituitary gland?

<p>Oxytocin (D)</p> Signup and view all the answers

What is the primary function of Adrenocorticotropic Hormone (ACTH)?

<p>Stimulates cortisol production (A)</p> Signup and view all the answers

Which system allows for rapid communication between the hypothalamus and the anterior pituitary?

<p>Hypothalamic-pituitary portal system (A)</p> Signup and view all the answers

Which hormone is released in response to stress and stimulates cortisol release?

<p>Corticotropin Releasing Hormone (CRH) (C)</p> Signup and view all the answers

Which of the following hormones plays a role in sperm production?

<p>Follicle Stimulating Hormone (FSH) (A)</p> Signup and view all the answers

What is the overall role of releasing hormones produced by the hypothalamus?

<p>Stimulate the synthesis and release of anterior pituitary hormones (C)</p> Signup and view all the answers

Which of the following is an inhibitory hormone produced by the hypothalamus?

<p>Gonadotropin Inhibitory Hormone (GnIH) (C)</p> Signup and view all the answers

What is the primary function of Thyroid Stimulating Hormone (TSH)?

<p>Promote thyroid hormone synthesis and secretion (D)</p> Signup and view all the answers

Which of the following hormones belongs to the Glycoprotein Family?

<p>Thyroid stimulating hormone (TSH) (B)</p> Signup and view all the answers

What can high levels of ACTH indicate in relation to cortisol production?

<p>Cushing’s syndrome (B)</p> Signup and view all the answers

What type of hormone structure does TSH have?

<p>Two subunits: common alpha and unique beta (C)</p> Signup and view all the answers

Which of the following symptoms is associated with hyperthyroidism?

<p>Increased metabolism and rapid weight loss (C)</p> Signup and view all the answers

What is the effect of TSH when thyroid hormone levels are low?

<p>It promotes increased thyroid hormone levels (B)</p> Signup and view all the answers

What effect does the common alpha subunit have in the Glycoprotein Family hormones?

<p>It is shared among multiple hormones including TSH, FSH, and LH (B)</p> Signup and view all the answers

In cases of a pituitary tumor secreting increased ACTH, what physiological condition may occur?

<p>Cushing’s syndrome (B)</p> Signup and view all the answers

What is the primary function of Prolactin (PRL) in the mammary gland?

<p>Promotion of mammary gland development and lactogenesis (D)</p> Signup and view all the answers

Which hormone suppresses the synthesis and secretion of prolactin in the anterior pituitary?

<p>Dopamine (D)</p> Signup and view all the answers

Which hormone is primarily responsible for the stimulation of growth in bones and cartilage?

<p>Growth Hormone (GH) (A)</p> Signup and view all the answers

In addition to stimulating growth, what effect does Growth Hormone (GH) have on carbohydrate metabolism?

<p>Decreases glucose uptake (B)</p> Signup and view all the answers

What triggers the release of prolactin during suckling?

<p>Stimulation of mechanoreceptors in the nipple (A)</p> Signup and view all the answers

What condition results from excessive secretion of Growth Hormone before the growth plates have fused?

<p>Gigantism (B)</p> Signup and view all the answers

How does Growth Hormone affect protein metabolism?

<p>Facilitates amino acid transport into muscles (A)</p> Signup and view all the answers

What does Growth Hormone stimulate in the liver for growth promotion?

<p>Insulin-like Growth Factor-1 (IGF-1) (D)</p> Signup and view all the answers

Which hormone family does Adrenocorticotrophic hormone (ACTH) belong to?

<p>POMC Family (D)</p> Signup and view all the answers

What is the role of thyroid releasing hormone (TRH) in prolactin regulation?

<p>Stimulates prolactin secretion (D)</p> Signup and view all the answers

What is a major effect of growth hormone on fat metabolism?

<p>Enhances lipolysis (D)</p> Signup and view all the answers

What happens to dopamine levels during suckling?

<p>They decrease (D)</p> Signup and view all the answers

What is a consequence of Growth Hormone disruption after the growth plates have fused?

<p>Acromegaly with connective tissue growth (D)</p> Signup and view all the answers

How is Prolactin structurally classified?

<p>Single chain protein (C)</p> Signup and view all the answers

Flashcards

Gigantism

Excessive growth hormone production.

Acromegaly

Growth hormone overproduction after bone growth plates close.

Growth Hormone (GH)

A hormone produced by the anterior pituitary gland responsible for growth and development.

Dwarfism

Pituitary Dwarfism, or hypopituitarism, is characterized by a lack of GH. It usually occurs before puberty.

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Prolactin (PRL)

Hormone regulating milk production in mammary glands.

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Thyroid Stimulating Hormone (TSH)

A hormone that stimulates the thyroid gland to produce thyroxine.

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Adrenocorticotropic Hormone (ACTH)

Stimulates the adrenal cortex to produce cortisol and aldosterone.

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Luteinizing Hormone (LH)

A hormone that stimulates ovulation in females and testosterone production in males.

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Secretory Pituitary Tumor

A type of pituitary tumor that produces excess amounts of a specific hormone.

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Pituitary Gland's Role

The pituitary gland is a small gland in the brain that controls other glands in the body, like the adrenal glands, thyroid, and gonads, by releasing specific hormones.

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Hypopituitarism

A condition where the pituitary gland is unable to produce sufficient amounts of one or more hormones.

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Posterior Pituitary

The posterior pituitary gland is an extension of the hypothalamus that stores and releases hormones produced by the hypothalamus, particularly oxytocin and vasopressin (ADH).

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Non-secretory Pituitary Tumor

This type of pituitary tumor does not produce excess hormones but instead interferes with the normal functioning of the pituitary gland.

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Hypothyroidism

A condition where the thyroid gland is underactive, resulting in decreased production of thyroid hormones.

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Hyperthyroidism

A state of excessive thyroid hormone production, leading to increased metabolic activity.

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Secondary Hypothyroidism

Disruption of thyroid hormone levels (T3 and T4) due to a problem with the pituitary gland.

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Primary Hypothyroidism

Disruption of thyroid hormone levels caused by a direct problem with the thyroid gland itself.

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T3 and T4 (Thyroid Hormones)

Hormones produced by the thyroid gland that regulate metabolism.

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What is the anterior pituitary gland?

The anterior pituitary gland is a vital part of the endocrine system, responsible for producing and releasing six key hormones that regulate various bodily functions.

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What are the 6 hormones produced by the anterior pituitary?

The anterior pituitary gland is responsible for producing and releasing 6 key hormones: Prolactin (PRL), Growth Hormone (GH), Thyroid Stimulating Hormone (TSH), Adrenocorticotropic Hormone (ACTH), Follicle Stimulating Hormone (FSH), and Luteinizing Hormone (LH).

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How are the six hormones produced by the anterior pituitary?

Different cell types within the anterior pituitary are specialized to produce each of the six hormones.

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What hormone stimulates milk production?

Prolactin (PRL) is a hormone produced by the anterior pituitary gland that primarily targets the mammary glands, stimulating the production of milk.

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What hormone is responsible for body growth?

Growth Hormone (GH) is produced by the anterior pituitary gland and plays a crucial role in regulating body growth, particularly in bone and muscle development.

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What hormone stimulates the thyroid gland?

Thyroid Stimulating Hormone (TSH) is produced by the anterior pituitary gland and acts on the thyroid gland to stimulate the production of thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3).

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What hormone stimulates the adrenal cortex?

Adrenocorticotropic Hormone (ACTH) is produced by the anterior pituitary gland and acts on the adrenal cortex to stimulate the production of cortisol and aldosterone, which are important for stress response and blood pressure regulation.

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What hormone stimulates follicle development and sperm production?

Follicle Stimulating Hormone (FSH) is produced by the anterior pituitary gland and plays a crucial role in regulating the development of ovarian follicles in females and sperm production in males.

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What hormone stimulates ovulation and testosterone secretion?

Luteinizing Hormone (LH) is produced by the anterior pituitary gland and plays a crucial role in regulating ovulation in females and testosterone secretion in males.

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How is the anterior pituitary gland regulated?

The hypothalamus, a region of the brain, plays a crucial role in regulating the anterior pituitary gland's hormone synthesis and secretion.

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What is ACTH?

ACTH is a hormone produced by the pituitary gland. It stimulates the production of cortisol by the adrenal cortex. It's part of the body's stress response system.

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How do cortisol and ACTH levels relate?

If cortisol levels are high, ACTH levels should be low in a normal, healthy individual. This is because cortisol acts as a negative feedback mechanism, inhibiting further ACTH production.

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What happens if there is a pituitary tumor secreting ACTH?

A pituitary tumor that secretes excessive amounts of ACTH can lead to Cushing's syndrome. This results in chronic high levels of cortisol, causing various symptoms including weight gain, muscle weakness, and skin changes.

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What is the Glycoprotein Family?

The glycoprotein family is a group of hormones that share a common alpha subunit and a unique beta subunit. These hormones include TSH, LH, and FSH.

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What is TSH?

TSH, also known as Thyrotropin, is a hormone produced by the pituitary gland that stimulates the thyroid gland to produce thyroid hormones (T3 and T4).

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What is the function of TSH?

TSH promotes the synthesis and secretion of thyroid hormones T3 and T4 by the thyroid gland. These hormones play vital roles in regulating metabolism, growth, and development.

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What happens if TSH levels are high?

High levels of TSH can lead to hyperthyroidism. This condition causes increased metabolic rate, leading to symptoms like rapid weight loss, increased appetite, and hyperactivity.

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What happens if TSH levels are low?

Low levels of TSH can lead to hypothyroidism. This condition causes decreased metabolic rate, leading to symptoms like weight gain, fatigue, and decreased body temperature.

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Anterior Pituitary Hormones

These hormones are produced in the anterior pituitary gland, a small gland at the base of the brain.

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Growth Hormone and Prolactin Family

This family of hormones includes growth hormone and prolactin - both play a crucial role in growth and development.

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POMC Family

This hormone family includes ACTH, which regulates the production of hormones like cortisol in the adrenal gland.

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Glycoprotein Family

This family includes TSH, which controls thyroid hormone production, and FSH and LH, which regulate the reproductive system.

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Prolactin

Hormone produced by lactotroph cells in the anterior pituitary, this hormone is also known as lactogenic hormone.

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Lactogenesis

The process of milk production, it involves synthesis and secretion of milk by the mammary glands.

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Prolactin Structure

Prolactin is a protein made up of a single chain with a molecular weight of 23KDa.

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Prolactin Family

Prolactin belongs to a group of related proteins including growth hormone and placental lactogen. These proteins share structural similarities.

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Prolactin Inhibition

Dopamine, a neurotransmitter, is released by the hypothalamus and inhibits prolactin production and secretion.

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Prolactin Releasing Hormone (PRH)

This hormone, released by the hypothalamus, promotes prolactin release.

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Thyroid Releasing Hormone (TRH) on Prolactin

Thyroid Releasing Hormone (TRH) is released by the hypothalamus and can also stimulate the release of prolactin.

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Estrogen on Prolactin

Estrogen, a female sex hormone, triggers prolactin secretion.

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Stimulation of Prolactin by Suckling

Suckling, stimulates prolactin secretion by inhibiting dopamine release from the hypothalamus.

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Prolactin in Mammary Gland Development

Prolactin helps in the development of the mammary glands, leading to an increase in the number of alveoli.

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Prolactin and Lactogenesis

Prolactin stimulates the production of milk proteins, crucial for the synthesis of milk.

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Somatotrope Cells

GH is produced by Somatotrope cells, found in the anterior pituitary gland.

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GH Secretion Pattern

GH is secreted in bursts throughout life, with higher peaks during sleep.

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Growth Hormone Releasing Hormone (GHRH)

This hormone, released by the hypothalamus, stimulates the release of GH.

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Growth Hormone Inhibiting Hormone (GHIH)

This hormone, also known as Somatostatin, inhibits GH release.

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GH and IGF-1

GH promotes the production of Insulin Like Growth Factor-1 (IGF-1) by the liver.

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GH and Protein Metabolism

GH promotes protein deposition by increasing amino acid transport and protein synthesis while reducing its breakdown.

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GH and Fat Metabolism

GH enhances fat utilization through increased lipolysis, releasing fatty acids that can be used for energy.

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GH and Glucose Metabolism

GH decreases carbohydrate metabolism, reducing glucose uptake by cells and potentially causing a decrease in insulin sensitivity.

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GH and Growth

GH directly stimulates bone and cartilage growth by increasing protein deposition and promoting the activity of osteoblasts.

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Acute Metabolic Effects of GH

The acute effects of GH on metabolism are temporary and occur in the short term, like decreased glucose uptake.

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Long-Term Body Growth Effects of GH

These are the long-term effects of GH, involving growth, and are influenced by factors like genetics and nutrition.

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GH Importance

GH is essential for growth and development throughout life, and disruptions can lead to growth disorders.

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Study Notes

Anterior Pituitary Hormones

  • Anterior pituitary hormones regulate various bodily functions
  • The hormones regulate the function of the thyroid, adrenal, ovaries/testes, mammary glands, and influence body growth
  • Specific anterior pituitary hormones affect different target glands and tissues:
    • Prolactin (PRL): Milk production in the mammary glands

    • Growth Hormone (GH): Influences bone and muscle growth, as well as liver function

    • Thyroid Stimulating Hormone (TSH): Regulates thyroid gland function

    • Adrenocorticotropic Hormone (ACTH): Controls the adrenal cortex

    • Follicle Stimulating Hormone (FSH): Impacts ovarian follicle development and sperm production

    • Luteinizing Hormone (LH): Influences ovarian follicle ovulation and testosterone secretion

Hypothalamic Control of Anterior Pituitary Hormones

  • The hypothalamus controls the release of anterior pituitary hormones
  • This is primarily achieved via "Releasing Hormones (RH)" and "Inhibiting Hormones (IH)"
  • These hormones are transported via the hypophyseal portal system directly to the anterior pituitary
  • Specific releasing hormones (PRH, GHRH, TRH, CRH and GnRH) regulate specific anterior pituitary hormone releases

Hypothalamic-Pituitary Portal System

  • The hypothalamic-pituitary portal system is essential in hormone function
  • This system directly takes hypothalamic neurohormones to the anterior pituitary
  • It involves two capillary beds connected by portal vessels.
  • This direct route ensures rapid response and prevents excessive dilution of hormones in the general circulation

Three Families of Anterior Pituitary Hormones

  • Anterior pituitary hormones are categorized into three families based on their structure:
    • Growth Hormone (GH) and Prolactin (PRL) Family
    • POMC (pro-opiomelanocortin) Family (includes ACTH)
    • Glycoprotein Family (includes TSH, FSH & LH)

Prolactin

  • Prolactin (PRL) is a single chain protein produced by lactotroph cells in the anterior pituitary

  • It promotes mammary gland development and function, often referred to as lactogenesis or milk production

  • Prolactin secretion is primarily controlled by dopamine from the hypothalamus which inhibits Prolactin secretion

  • Stimulation of prolactin release comes from the hypothalamic releasing peptide (PRH) and the thyroid releasing hormone (TRH) and estrogen from the ovaries

Growth Hormone (GH)

  • GH is a single chain protein, produced by somatotrope cells in the anterior pituitary
  • It's one of the most abundant pituitary proteins and it influences body growth and metabolism.
  • GH secretion is controlled by hypothalamic GHRH (growth hormone releasing hormone) and GHIH (growth hormone inhibiting hormone - also called Somatostatin)

ACTH

  • ACTH stimulates the adrenal cortex
  • It influences immune, liver, muscle and adipose tissue function
  • Cortisol levels and long-loop negative feedback regulate ACTH secretion

Thyroid Stimulating Hormone (TSH)

  • TSH acts on the thyroid gland

  • It's a glycoprotein composed of two subunits and is crucial for thyroid hormone synthesis and release

  • TSH levels are regulated by TRH from the hypothalamus

Gonadotropins (FSH & LH)

  • FSH and LH are essential for reproduction
  • They impact the development of follicles, sperm production, ovulation, and sex steroid hormone production
  • Secretion is regulated by the hypothalamic GnRH (gonadotropin releasing hormone)

Pituitary Gland Disorders

  • Pituitary gland dysfunctions can lead to various hormonal imbalances;

  • Hyper- and hypothyroidism( disfunction in TSH and Thyroid hormones)

  • Cushing's disease (high ACTH / Cortisol)

  • Secondary Addison's Disease ( low ACTH/ Cortisol/ Aldosterone)

  • Acromegaly/Dwarfism (Disruption of GH)

  • Infertility/ Delayed onset of puberty(Disruption of FSH & LH & sex steroid hormones)

  • Isolated defects in single hormones may occur as can deficiencies in several hormones.

  • Causes include traumatic injury, pituitary tumours and hypothalamus connection damage.

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