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Questions and Answers
A patient presents with symptoms of Cushing's Syndrome. Which pituitary hormone is most likely responsible for this condition?
A patient presents with symptoms of Cushing's Syndrome. Which pituitary hormone is most likely responsible for this condition?
- Adrenocorticotropic Hormone (ACTH) (correct)
- Growth Hormone (GH)
- Prolactin
- Thyroid Stimulating Hormone (TSH)
Which of the following statements is TRUE about pituitary tumors (adenomas)?
Which of the following statements is TRUE about pituitary tumors (adenomas)?
- They are always metastatic.
- They always interfere with normal hormone production.
- They can be classified as secretory or non-secretory. (correct)
- They only affect women, as they are more prevalent.
- All of the above
What is the primary difference between the anterior and posterior pituitary glands?
What is the primary difference between the anterior and posterior pituitary glands?
- The anterior pituitary produces hormones, while the posterior pituitary only stores and releases them. (correct)
- The anterior pituitary is controlled by the hypothalamus via neural input, while the posterior pituitary is controlled via the portal vasculature.
- The anterior pituitary is derived from neural tissue, while the posterior pituitary is derived from ectoderm.
- The anterior pituitary produces hormones that regulate other endocrine glands, while the posterior pituitary produces hormones that directly affect target tissues.
What is the role of the hypothalamus in regulating pituitary hormone secretion?
What is the role of the hypothalamus in regulating pituitary hormone secretion?
What is a possible consequence of hyposecretion of growth hormone (GH) in childhood?
What is a possible consequence of hyposecretion of growth hormone (GH) in childhood?
What is a primary cause of dwarfism related to growth hormone?
What is a primary cause of dwarfism related to growth hormone?
Which hormone is NOT disrupted in pituitary dwarfism in dogs?
Which hormone is NOT disrupted in pituitary dwarfism in dogs?
Which condition is characterized by disproportionate growth?
Which condition is characterized by disproportionate growth?
What is the function of growth hormone in the anterior pituitary?
What is the function of growth hormone in the anterior pituitary?
Which of the following is associated with congenital problems in pituitary gland development?
Which of the following is associated with congenital problems in pituitary gland development?
What is one of the common clinical manifestations of pituitary dwarfism in dogs?
What is one of the common clinical manifestations of pituitary dwarfism in dogs?
What are the two main families of hormones secreted by the anterior pituitary?
What are the two main families of hormones secreted by the anterior pituitary?
Which hormone stimulates milk production in mammals?
Which hormone stimulates milk production in mammals?
What condition is associated with high TSH and low T3/T4 levels?
What condition is associated with high TSH and low T3/T4 levels?
Which hormone is responsible for stimulating ovulation in females?
Which hormone is responsible for stimulating ovulation in females?
What is the primary consequence of anterior pituitary gland dysfunction?
What is the primary consequence of anterior pituitary gland dysfunction?
Which hormone(s) are primarily produced in the gonadotropes of the anterior pituitary?
Which hormone(s) are primarily produced in the gonadotropes of the anterior pituitary?
Which of the following conditions is characterized by low TSH and low T3/T4?
Which of the following conditions is characterized by low TSH and low T3/T4?
What is the effect of Follicle Stimulating Hormone (FSH) in males?
What is the effect of Follicle Stimulating Hormone (FSH) in males?
What condition is characterized by high T3/T4 and low TSH levels?
What condition is characterized by high T3/T4 and low TSH levels?
Which of the following hormones is primarily associated with the regulation of stress response?
Which of the following hormones is primarily associated with the regulation of stress response?
Which of the following hormones is primarily responsible for milk production?
Which of the following hormones is primarily responsible for milk production?
What cell type produces Growth Hormone (GH) in the anterior pituitary?
What cell type produces Growth Hormone (GH) in the anterior pituitary?
Thyroid Stimulating Hormone (TSH) primarily acts on which gland?
Thyroid Stimulating Hormone (TSH) primarily acts on which gland?
Which of the following hormones is NOT produced by the anterior pituitary gland?
Which of the following hormones is NOT produced by the anterior pituitary gland?
What is the primary function of Adrenocorticotropic Hormone (ACTH)?
What is the primary function of Adrenocorticotropic Hormone (ACTH)?
Which system allows for rapid communication between the hypothalamus and the anterior pituitary?
Which system allows for rapid communication between the hypothalamus and the anterior pituitary?
Which hormone is released in response to stress and stimulates cortisol release?
Which hormone is released in response to stress and stimulates cortisol release?
Which of the following hormones plays a role in sperm production?
Which of the following hormones plays a role in sperm production?
What is the overall role of releasing hormones produced by the hypothalamus?
What is the overall role of releasing hormones produced by the hypothalamus?
Which of the following is an inhibitory hormone produced by the hypothalamus?
Which of the following is an inhibitory hormone produced by the hypothalamus?
What is the primary function of Thyroid Stimulating Hormone (TSH)?
What is the primary function of Thyroid Stimulating Hormone (TSH)?
Which of the following hormones belongs to the Glycoprotein Family?
Which of the following hormones belongs to the Glycoprotein Family?
What can high levels of ACTH indicate in relation to cortisol production?
What can high levels of ACTH indicate in relation to cortisol production?
What type of hormone structure does TSH have?
What type of hormone structure does TSH have?
Which of the following symptoms is associated with hyperthyroidism?
Which of the following symptoms is associated with hyperthyroidism?
What is the effect of TSH when thyroid hormone levels are low?
What is the effect of TSH when thyroid hormone levels are low?
What effect does the common alpha subunit have in the Glycoprotein Family hormones?
What effect does the common alpha subunit have in the Glycoprotein Family hormones?
In cases of a pituitary tumor secreting increased ACTH, what physiological condition may occur?
In cases of a pituitary tumor secreting increased ACTH, what physiological condition may occur?
What is the primary function of Prolactin (PRL) in the mammary gland?
What is the primary function of Prolactin (PRL) in the mammary gland?
Which hormone suppresses the synthesis and secretion of prolactin in the anterior pituitary?
Which hormone suppresses the synthesis and secretion of prolactin in the anterior pituitary?
Which hormone is primarily responsible for the stimulation of growth in bones and cartilage?
Which hormone is primarily responsible for the stimulation of growth in bones and cartilage?
In addition to stimulating growth, what effect does Growth Hormone (GH) have on carbohydrate metabolism?
In addition to stimulating growth, what effect does Growth Hormone (GH) have on carbohydrate metabolism?
What triggers the release of prolactin during suckling?
What triggers the release of prolactin during suckling?
What condition results from excessive secretion of Growth Hormone before the growth plates have fused?
What condition results from excessive secretion of Growth Hormone before the growth plates have fused?
How does Growth Hormone affect protein metabolism?
How does Growth Hormone affect protein metabolism?
What does Growth Hormone stimulate in the liver for growth promotion?
What does Growth Hormone stimulate in the liver for growth promotion?
Which hormone family does Adrenocorticotrophic hormone (ACTH) belong to?
Which hormone family does Adrenocorticotrophic hormone (ACTH) belong to?
What is the role of thyroid releasing hormone (TRH) in prolactin regulation?
What is the role of thyroid releasing hormone (TRH) in prolactin regulation?
What is a major effect of growth hormone on fat metabolism?
What is a major effect of growth hormone on fat metabolism?
What happens to dopamine levels during suckling?
What happens to dopamine levels during suckling?
What is a consequence of Growth Hormone disruption after the growth plates have fused?
What is a consequence of Growth Hormone disruption after the growth plates have fused?
How is Prolactin structurally classified?
How is Prolactin structurally classified?
Flashcards
Gigantism
Gigantism
Excessive growth hormone production.
Acromegaly
Acromegaly
Growth hormone overproduction after bone growth plates close.
Growth Hormone (GH)
Growth Hormone (GH)
A hormone produced by the anterior pituitary gland responsible for growth and development.
Dwarfism
Dwarfism
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Prolactin (PRL)
Prolactin (PRL)
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Thyroid Stimulating Hormone (TSH)
Thyroid Stimulating Hormone (TSH)
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Adrenocorticotropic Hormone (ACTH)
Adrenocorticotropic Hormone (ACTH)
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Luteinizing Hormone (LH)
Luteinizing Hormone (LH)
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Secretory Pituitary Tumor
Secretory Pituitary Tumor
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Pituitary Gland's Role
Pituitary Gland's Role
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Hypopituitarism
Hypopituitarism
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Posterior Pituitary
Posterior Pituitary
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Non-secretory Pituitary Tumor
Non-secretory Pituitary Tumor
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Hypothyroidism
Hypothyroidism
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Hyperthyroidism
Hyperthyroidism
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Secondary Hypothyroidism
Secondary Hypothyroidism
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Primary Hypothyroidism
Primary Hypothyroidism
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T3 and T4 (Thyroid Hormones)
T3 and T4 (Thyroid Hormones)
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What is the anterior pituitary gland?
What is the anterior pituitary gland?
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What are the 6 hormones produced by the anterior pituitary?
What are the 6 hormones produced by the anterior pituitary?
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How are the six hormones produced by the anterior pituitary?
How are the six hormones produced by the anterior pituitary?
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What hormone stimulates milk production?
What hormone stimulates milk production?
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What hormone is responsible for body growth?
What hormone is responsible for body growth?
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What hormone stimulates the thyroid gland?
What hormone stimulates the thyroid gland?
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What hormone stimulates the adrenal cortex?
What hormone stimulates the adrenal cortex?
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What hormone stimulates follicle development and sperm production?
What hormone stimulates follicle development and sperm production?
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What hormone stimulates ovulation and testosterone secretion?
What hormone stimulates ovulation and testosterone secretion?
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How is the anterior pituitary gland regulated?
How is the anterior pituitary gland regulated?
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What is ACTH?
What is ACTH?
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How do cortisol and ACTH levels relate?
How do cortisol and ACTH levels relate?
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What happens if there is a pituitary tumor secreting ACTH?
What happens if there is a pituitary tumor secreting ACTH?
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What is the Glycoprotein Family?
What is the Glycoprotein Family?
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What is TSH?
What is TSH?
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What is the function of TSH?
What is the function of TSH?
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What happens if TSH levels are high?
What happens if TSH levels are high?
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What happens if TSH levels are low?
What happens if TSH levels are low?
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Anterior Pituitary Hormones
Anterior Pituitary Hormones
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Growth Hormone and Prolactin Family
Growth Hormone and Prolactin Family
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POMC Family
POMC Family
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Glycoprotein Family
Glycoprotein Family
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Prolactin
Prolactin
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Lactogenesis
Lactogenesis
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Prolactin Structure
Prolactin Structure
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Prolactin Family
Prolactin Family
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Prolactin Inhibition
Prolactin Inhibition
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Prolactin Releasing Hormone (PRH)
Prolactin Releasing Hormone (PRH)
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Thyroid Releasing Hormone (TRH) on Prolactin
Thyroid Releasing Hormone (TRH) on Prolactin
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Estrogen on Prolactin
Estrogen on Prolactin
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Stimulation of Prolactin by Suckling
Stimulation of Prolactin by Suckling
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Prolactin in Mammary Gland Development
Prolactin in Mammary Gland Development
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Prolactin and Lactogenesis
Prolactin and Lactogenesis
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Somatotrope Cells
Somatotrope Cells
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GH Secretion Pattern
GH Secretion Pattern
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Growth Hormone Releasing Hormone (GHRH)
Growth Hormone Releasing Hormone (GHRH)
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Growth Hormone Inhibiting Hormone (GHIH)
Growth Hormone Inhibiting Hormone (GHIH)
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GH and IGF-1
GH and IGF-1
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GH and Protein Metabolism
GH and Protein Metabolism
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GH and Fat Metabolism
GH and Fat Metabolism
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GH and Glucose Metabolism
GH and Glucose Metabolism
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GH and Growth
GH and Growth
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Acute Metabolic Effects of GH
Acute Metabolic Effects of GH
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Long-Term Body Growth Effects of GH
Long-Term Body Growth Effects of GH
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GH Importance
GH Importance
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Study Notes
Anterior Pituitary Hormones
- Anterior pituitary hormones regulate various bodily functions
- The hormones regulate the function of the thyroid, adrenal, ovaries/testes, mammary glands, and influence body growth
- Specific anterior pituitary hormones affect different target glands and tissues:
-
Prolactin (PRL): Milk production in the mammary glands
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Growth Hormone (GH): Influences bone and muscle growth, as well as liver function
-
Thyroid Stimulating Hormone (TSH): Regulates thyroid gland function
-
Adrenocorticotropic Hormone (ACTH): Controls the adrenal cortex
-
Follicle Stimulating Hormone (FSH): Impacts ovarian follicle development and sperm production
-
Luteinizing Hormone (LH): Influences ovarian follicle ovulation and testosterone secretion
-
Hypothalamic Control of Anterior Pituitary Hormones
- The hypothalamus controls the release of anterior pituitary hormones
- This is primarily achieved via "Releasing Hormones (RH)" and "Inhibiting Hormones (IH)"
- These hormones are transported via the hypophyseal portal system directly to the anterior pituitary
- Specific releasing hormones (PRH, GHRH, TRH, CRH and GnRH) regulate specific anterior pituitary hormone releases
Hypothalamic-Pituitary Portal System
- The hypothalamic-pituitary portal system is essential in hormone function
- This system directly takes hypothalamic neurohormones to the anterior pituitary
- It involves two capillary beds connected by portal vessels.
- This direct route ensures rapid response and prevents excessive dilution of hormones in the general circulation
Three Families of Anterior Pituitary Hormones
- Anterior pituitary hormones are categorized into three families based on their structure:
- Growth Hormone (GH) and Prolactin (PRL) Family
- POMC (pro-opiomelanocortin) Family (includes ACTH)
- Glycoprotein Family (includes TSH, FSH & LH)
Prolactin
-
Prolactin (PRL) is a single chain protein produced by lactotroph cells in the anterior pituitary
-
It promotes mammary gland development and function, often referred to as lactogenesis or milk production
-
Prolactin secretion is primarily controlled by dopamine from the hypothalamus which inhibits Prolactin secretion
-
Stimulation of prolactin release comes from the hypothalamic releasing peptide (PRH) and the thyroid releasing hormone (TRH) and estrogen from the ovaries
Growth Hormone (GH)
- GH is a single chain protein, produced by somatotrope cells in the anterior pituitary
- It's one of the most abundant pituitary proteins and it influences body growth and metabolism.
- GH secretion is controlled by hypothalamic GHRH (growth hormone releasing hormone) and GHIH (growth hormone inhibiting hormone - also called Somatostatin)
ACTH
- ACTH stimulates the adrenal cortex
- It influences immune, liver, muscle and adipose tissue function
- Cortisol levels and long-loop negative feedback regulate ACTH secretion
Thyroid Stimulating Hormone (TSH)
-
TSH acts on the thyroid gland
-
It's a glycoprotein composed of two subunits and is crucial for thyroid hormone synthesis and release
-
TSH levels are regulated by TRH from the hypothalamus
Gonadotropins (FSH & LH)
- FSH and LH are essential for reproduction
- They impact the development of follicles, sperm production, ovulation, and sex steroid hormone production
- Secretion is regulated by the hypothalamic GnRH (gonadotropin releasing hormone)
Pituitary Gland Disorders
-
Pituitary gland dysfunctions can lead to various hormonal imbalances;
-
Hyper- and hypothyroidism( disfunction in TSH and Thyroid hormones)
-
Cushing's disease (high ACTH / Cortisol)
-
Secondary Addison's Disease ( low ACTH/ Cortisol/ Aldosterone)
-
Acromegaly/Dwarfism (Disruption of GH)
-
Infertility/ Delayed onset of puberty(Disruption of FSH & LH & sex steroid hormones)
-
Isolated defects in single hormones may occur as can deficiencies in several hormones.
-
Causes include traumatic injury, pituitary tumours and hypothalamus connection damage.
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