Ante-Mortem Analysis for Rabies Diagnosis [Trans 2023]

Play an AI-generated podcast conversation about this lesson

What is the recommended protective antibody level in serum to indicate post-vaccination immunity for rabies?

1.0 IU/mL

2.0 IU/mL

0.1 IU/mL

0.5 IU/mL (correct)

Which test can be used to detect antibodies to rabies in serum or cerebrospinal fluid (CSF)?

PCR

RFFIT (correct)

ELISA

Western blot

What manifestation of rabies encephalitis can be detected with any amount of antibodies in the cerebrospinal fluid?

Neurological deficits

Encephalitis (correct)

Seizures

Memory loss

In diagnosing rabies pre-mortem, what can be useful alongside serologic testing?

Lumbar puncture Signup and view all the answers

What is the duration of animal observation recommended in the Philippines for suspected rabies exposure?

21 days Signup and view all the answers

What type of bodies are typically seen in histopathologic examination of the central nervous system (CNS) in cases of rabies?

Negri bodies Signup and view all the answers

What is the most suitable sample for ante-mortem analysis of Rabies using RT-PCR?

Saliva (1mL) or saliva swab Signup and view all the answers

Which type of sample collection can be repeated depending on the length of the survival period for Rabies diagnosis?

Saliva (1mL) or saliva swab Signup and view all the answers

Which test is NOT recommended for Rabies diagnosis due to its long duration?

Viral Isolation Signup and view all the answers

What is the purpose of identifying Negri bodies in the CNS of an inoculated animal in Rabies diagnosis?

To confirm encephalitis caused by rabies infection Signup and view all the answers

In which animal model is the isolation of rabies virus particularly fast in specialized laboratories?

Hamsters Signup and view all the answers

Which serological test is used to detect antibodies against rabies virus, assisting in rabies diagnosis?

ELISA Signup and view all the answers

What is the significance of Negri bodies in diagnosing rabies?

They are not observed in at least 20% of rabies cases. Signup and view all the answers

What is the purpose of the RFFIT test in rabies diagnosis?

To measure neutralizing antibodies against rabies virus. Signup and view all the answers

Which organ has the highest titers of rabies virus?

Submaxillary salivary gland Signup and view all the answers

Why is viral isolation from the blood not a reliable method for diagnosing rabies?

The virus is not present in the blood of infected persons. Signup and view all the answers

What factors can influence susceptibility to rabies infection and the incubation period?

Host age and immune status Signup and view all the answers

How do bite sites on different parts of the body affect rabies infection severity?

Bites on the head or face result in higher attack rates and shorter incubation periods. Signup and view all the answers