Ante-Mortem Analysis for Rabies Diagnosis [Trans 2023]
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Questions and Answers

What is the recommended protective antibody level in serum to indicate post-vaccination immunity for rabies?

  • 1.0 IU/mL
  • 2.0 IU/mL
  • 0.1 IU/mL
  • 0.5 IU/mL (correct)
  • Which test can be used to detect antibodies to rabies in serum or cerebrospinal fluid (CSF)?

  • PCR
  • RFFIT (correct)
  • ELISA
  • Western blot
  • What manifestation of rabies encephalitis can be detected with any amount of antibodies in the cerebrospinal fluid?

  • Neurological deficits
  • Encephalitis (correct)
  • Seizures
  • Memory loss
  • In diagnosing rabies pre-mortem, what can be useful alongside serologic testing?

    <p>Lumbar puncture</p> Signup and view all the answers

    What is the duration of animal observation recommended in the Philippines for suspected rabies exposure?

    <p>21 days</p> Signup and view all the answers

    What type of bodies are typically seen in histopathologic examination of the central nervous system (CNS) in cases of rabies?

    <p>Negri bodies</p> Signup and view all the answers

    What is the most suitable sample for ante-mortem analysis of Rabies using RT-PCR?

    <p>Saliva (1mL) or saliva swab</p> Signup and view all the answers

    Which type of sample collection can be repeated depending on the length of the survival period for Rabies diagnosis?

    <p>Saliva (1mL) or saliva swab</p> Signup and view all the answers

    Which test is NOT recommended for Rabies diagnosis due to its long duration?

    <p>Viral Isolation</p> Signup and view all the answers

    What is the purpose of identifying Negri bodies in the CNS of an inoculated animal in Rabies diagnosis?

    <p>To confirm encephalitis caused by rabies infection</p> Signup and view all the answers

    In which animal model is the isolation of rabies virus particularly fast in specialized laboratories?

    <p>Hamsters</p> Signup and view all the answers

    Which serological test is used to detect antibodies against rabies virus, assisting in rabies diagnosis?

    <p>ELISA</p> Signup and view all the answers

    What is the significance of Negri bodies in diagnosing rabies?

    <p>They are not observed in at least 20% of rabies cases.</p> Signup and view all the answers

    What is the purpose of the RFFIT test in rabies diagnosis?

    <p>To measure neutralizing antibodies against rabies virus.</p> Signup and view all the answers

    Which organ has the highest titers of rabies virus?

    <p>Submaxillary salivary gland</p> Signup and view all the answers

    Why is viral isolation from the blood not a reliable method for diagnosing rabies?

    <p>The virus is not present in the blood of infected persons.</p> Signup and view all the answers

    What factors can influence susceptibility to rabies infection and the incubation period?

    <p>Host age and immune status</p> Signup and view all the answers

    How do bite sites on different parts of the body affect rabies infection severity?

    <p>Bites on the head or face result in higher attack rates and shorter incubation periods.</p> Signup and view all the answers

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