Ante-Mortem Analysis for Rabies Diagnosis [Trans 2023]

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Questions and Answers

What is the recommended protective antibody level in serum to indicate post-vaccination immunity for rabies?

  • 1.0 IU/mL
  • 2.0 IU/mL
  • 0.1 IU/mL
  • 0.5 IU/mL (correct)

Which test can be used to detect antibodies to rabies in serum or cerebrospinal fluid (CSF)?

  • PCR
  • RFFIT (correct)
  • ELISA
  • Western blot

What manifestation of rabies encephalitis can be detected with any amount of antibodies in the cerebrospinal fluid?

  • Neurological deficits
  • Encephalitis (correct)
  • Seizures
  • Memory loss

In diagnosing rabies pre-mortem, what can be useful alongside serologic testing?

<p>Lumbar puncture (B)</p> Signup and view all the answers

What is the duration of animal observation recommended in the Philippines for suspected rabies exposure?

<p>21 days (C)</p> Signup and view all the answers

What type of bodies are typically seen in histopathologic examination of the central nervous system (CNS) in cases of rabies?

<p>Negri bodies (A)</p> Signup and view all the answers

What is the most suitable sample for ante-mortem analysis of Rabies using RT-PCR?

<p>Saliva (1mL) or saliva swab (C)</p> Signup and view all the answers

Which type of sample collection can be repeated depending on the length of the survival period for Rabies diagnosis?

<p>Saliva (1mL) or saliva swab (D)</p> Signup and view all the answers

Which test is NOT recommended for Rabies diagnosis due to its long duration?

<p>Viral Isolation (A)</p> Signup and view all the answers

What is the purpose of identifying Negri bodies in the CNS of an inoculated animal in Rabies diagnosis?

<p>To confirm encephalitis caused by rabies infection (D)</p> Signup and view all the answers

In which animal model is the isolation of rabies virus particularly fast in specialized laboratories?

<p>Hamsters (B)</p> Signup and view all the answers

Which serological test is used to detect antibodies against rabies virus, assisting in rabies diagnosis?

<p>ELISA (D)</p> Signup and view all the answers

What is the significance of Negri bodies in diagnosing rabies?

<p>They are not observed in at least 20% of rabies cases. (B)</p> Signup and view all the answers

What is the purpose of the RFFIT test in rabies diagnosis?

<p>To measure neutralizing antibodies against rabies virus. (D)</p> Signup and view all the answers

Which organ has the highest titers of rabies virus?

<p>Submaxillary salivary gland (D)</p> Signup and view all the answers

Why is viral isolation from the blood not a reliable method for diagnosing rabies?

<p>The virus is not present in the blood of infected persons. (A)</p> Signup and view all the answers

What factors can influence susceptibility to rabies infection and the incubation period?

<p>Host age and immune status (D)</p> Signup and view all the answers

How do bite sites on different parts of the body affect rabies infection severity?

<p>Bites on the head or face result in higher attack rates and shorter incubation periods. (A)</p> Signup and view all the answers

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