Animal Health Protection in Research Institutions Quiz

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the purpose of purchasing animals from reputable vendors with good health screening programs?

To save money on animal purchases

To increase the variety of animals in the facility

To avoid infections and health problems in the colony animals (correct)

To ensure the animals are of high quality

Why is it important to follow procedures for receiving, handling, and quarantining animals entering the facility?

To make sure the animals are comfortable in their new environment

To protect the health status of the colony animals (correct)

To avoid legal issues with the vendors

To increase the productivity of the research

What are acclimation and conditioning periods for animals entering the facility?

Periods of time where the animals are given special diets

Periods of time where the animals are not allowed to move around

Periods of time where the animals adjust to their new environment (correct)

Periods of time where the animals are allowed to interact with other animals

Where do biomedical research facilities usually purchase rodents, rabbits, and purpose-bred cats and dogs from?

Class A dealers Signup and view all the answers

Which type of dealer is less likely to provide information on the health status of their animals from birth?

Class B dealers Signup and view all the answers

What is the advantage of breeding research animals in-house for some institutions?

All of the above Signup and view all the answers

What is the definition of 'microbiological status'?

The types of microorganisms that the animal is carrying. Signup and view all the answers

What is the meaning of 'gnotobiotic'?

Known life Signup and view all the answers

What is the difference between 'specific pathogen-free' and 'germfree' animals?

SPF animals are free of specific pathogens, while germfree animals have no microorganisms at all. Signup and view all the answers

What is the difference between defined flora and germfree animals?

Defined flora animals are deliberately given a cocktail containing harmless bacteria, while germfree animals have no bacteria in their intestinal tract Signup and view all the answers

What is the difference between germfree animals and specific pathogen-free (SPF) animals?

Germfree animals are bred, reared, and maintained in a completely sterile environment, while SPF animals are monitored using diagnostic tests to ensure their SPF status Signup and view all the answers

Why is it important to know the specific pathogens eliminated from animal colonies by vendors?

To know which pathogens an SPF animal is free of before placing it with animals that have a different microbiological status Signup and view all the answers

What information is required on procurement forms for laboratory animals?

Species, strain, sex, age, microbiologic status, and any special housing requirements Signup and view all the answers

What is the importance of a centralized animal purchasing system?

Allows for adequate space, caging type, staffing levels, and supplies management Signup and view all the answers

What is the role of an approved protocol number in the procurement of laboratory animals?

Animals must be associated with an approved protocol number before they are ordered Signup and view all the answers

What is the purpose of health screening reports from vendors?

To ensure the quality of animals purchased Signup and view all the answers

What are the requirements for the transportation of laboratory animals according to the AWR?

Temperature ranges, ventilation, cleanliness, space, and feeding and watering requirements Signup and view all the answers

What is the recommended mode of transportation for laboratory animals?

Climate-controlled vehicles Signup and view all the answers

What is the responsibility of the receiving staff when laboratory animals are delivered?

Observe and record the condition of the transport containers and the transportation vehicle, comparing labels and contents to ensure they match the order specifications Signup and view all the answers

Why is individual identification necessary for large laboratory animals?

For proper record-keeping Signup and view all the answers

What is the purpose of quarantine for newly acquired animals in research facilities?

To prevent the introduction of foreign pathogens Signup and view all the answers

Under what circumstances may animals of known health status from approved vendors not require quarantine?

When the veterinary staff determines it based on species, vendor record, and regulations Signup and view all the answers

What is the purpose of acclimation for newly acquired animals in research facilities?

To minimize stress during experimentation Signup and view all the answers

Why do quarantine rooms in research facilities need to be maintained under negative air pressure?

To minimize the chance of microorganism transmission Signup and view all the answers

What is the purpose of daily records for quarantined animals in research facilities?

To document observations and assessments performed according to the facility’s SOP Signup and view all the answers

Why do most facilities restrict access and limit research activities on animals during quarantine, acclimation, or conditioning periods?

To minimize stress on the animals Signup and view all the answers

What is the purpose of conditioning for animals in research facilities?

To return animals to a physiological normal baseline status Signup and view all the answers

Study Notes

Procurement and Transportation of Laboratory Animals

A centralized animal purchasing system allows for adequate space, caging type, staffing levels, and supplies management.
Animals must be associated with an approved protocol number before they are ordered.
Animals may be ordered from vendors locally, internationally, or from colleagues within the same institution.
Procurement forms require specific information about the requested animals, including species, strain, sex, age, microbiologic status, and any special housing requirements.
Vendors vary in the quality of animals they provide, and many institutions only purchase from vendors that provide health screening reports.
The transportation of laboratory animals is strictly regulated by the AWR, specifying temperature ranges, ventilation, cleanliness, space, and feeding and watering requirements.
Animals should be transported in climate-controlled vehicles to minimize stress and exposure to pathogens or environmental conditions.
The type of carrier selected depends on the proximity of the facility to an airport and the proximity of the institution to the vendor.
The receiving staff should observe and record the condition of the transport containers and the transportation vehicle, comparing labels and contents to ensure they match the order specifications.
Once a shipment is signed for, the animals are moved to a designated room to receive new animals, and the outside of the transport container should be disinfected before removing the animals.
Animals should be examined for signs of pain or distress, sickness, or aggressiveness, noting any abnormalities in breathing or movement.
Large animals require a physical or preliminary examination by the veterinary staff, and individual identification is necessary for proper record-keeping.

Quarantine, Acclimation, and Conditioning of Newly Acquired Animals in Research Facilities

Newly acquired animals are isolated from in-house colonies for a period of time to prevent the introduction of foreign pathogens, a process known as quarantine.
Reasons for quarantine include evaluation of the health of new arrivals, prevention of disease transmission, recovery from transportation stress, adjustment to new surroundings, baseline data collection, vaccination/treatment/deworming, and application of tattoos/microchips.
Animals of known health status from approved vendors may not require quarantine, but the veterinary staff determines the need and length of quarantine based on species, vendor record, and regulations.
Animal care staff must complete daily records to document observations and assessments performed according to the facility’s SOP for quarantined animals.
Health documents accompanying animal shipments do not exempt animals from quarantine as they may have been exposed to infectious agents during transit.
Newly received animals are quarantined long enough for pathogen exposure to register on test results before being retested and released.
Quarantine rooms are maintained under negative air pressure to minimize the chance of microorganism transmission.
SOPs should be followed, including clothing changes and correct use of PPE, to avoid disease transmission between animals in colonies and quarantine.
Acclimation allows animals to recover from transportation stress and adjust to environmental conditions before use in a study, minimizing stress during experimentation.
Stressed animals may secrete higher than normal levels of certain hormones, which could cause errors in research results.
Most facilities restrict access and limit research activities on animals during quarantine, acclimation, or conditioning periods.
Conditioning involves providing extra resources to return animals to a physiological normal baseline status, such as treatments for parasites and high-energy diets, and typically takes place during acclimation and quarantine periods. NHPs require at least 14 days for acclimation and conditioning.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Protecting Animal Health in Research Institutions Quiz: Test Your Knowledge on Preventing Infections and Ensuring Animal Welfare. Learn about the Importance of Health Screening Programs for Animal Vendors and Proper Procedures for Receiving and Quarantining New Animals. Enhance your understanding of maintaining research integrity by safeguarding animal health.