Angiotensin 2 Function and Targets
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Questions and Answers

What is the approximate number of amino acids in the hormone angiotensin 2?

  • 10
  • 12
  • 8 (correct)
  • 5

What is the effect of angiotensin 2 on smooth muscle in blood vessels?

  • No effect
  • Constriction (correct)
  • Growth
  • Relaxation

What happens to blood pressure when vasoconstriction occurs?

  • It fluctuates
  • It increases (correct)
  • It remains the same
  • It decreases

What is the formula that relates blood pressure to flow and resistance?

<p>ΔP = Q × R (C)</p> Signup and view all the answers

What is the term for the constriction of blood vessels?

<p>Vasoconstriction (D)</p> Signup and view all the answers

What is the effect of increased resistance on blood pressure?

<p>It increases (A)</p> Signup and view all the answers

What are the two components of flow (Q) in the formula ΔP = Q × R?

<p>Stroke volume and heart rate (B)</p> Signup and view all the answers

What is the meaning of the prefix 'angio' in the word 'angiotensin'?

<p>Blood vessel (B)</p> Signup and view all the answers

What is the effect of angiotensin 2 on blood vessels?

<p>Constriction (D)</p> Signup and view all the answers

What is the rapid response of blood vessels to angiotensin 2?

<p>Constriction (A)</p> Signup and view all the answers

What is the effect of sodium reabsorption on urine?

<p>Concentrated urine (D)</p> Signup and view all the answers

What is the effect of ADH on blood vessels?

<p>Vasoconstriction (C)</p> Signup and view all the answers

What is the main function of aldosterone?

<p>Salt reabsorption (C)</p> Signup and view all the answers

What is the effect of increased stroke volume on arterial pressure?

<p>Increased pressure (D)</p> Signup and view all the answers

What is the target organ affected by angiotensin 2 that responds slowly?

<p>Kidneys (A)</p> Signup and view all the answers

What is the effect of water reabsorption on blood pressure?

<p>Increased pressure (D)</p> Signup and view all the answers

What is the function of the pituitary gland in response to angiotensin 2?

<p>Releasing ADH (B)</p> Signup and view all the answers

What is the result of increased resistance and increased stroke volume on blood pressure?

<p>Increased pressure (A)</p> Signup and view all the answers

What is the purpose of reabsorbing water in the nephron?

<p>To increase blood pressure (B)</p> Signup and view all the answers

Why does the sodium reabsorption strategy work?

<p>Because the nephron is permeable to water (B)</p> Signup and view all the answers

What happens when you try to reabsorb salt in an area of the nephron that is not permeable to water?

<p>Water bounces off the barrier (A)</p> Signup and view all the answers

What is the strategy used by ADH to reabsorb water in areas of the nephron that are not permeable to water?

<p>Creating little channels for water to pass through (B)</p> Signup and view all the answers

Why do aldosterone and angiotensin 2 work in areas of the nephron that are permeable to water?

<p>Because they use the salt gradient approach (C)</p> Signup and view all the answers

What is the key to increasing stroke volume in both situations?

<p>Getting water back into the blood (B)</p> Signup and view all the answers

What is the difference between how ADH and aldosterone/angiotensin 2 work?

<p>ADH works in areas impermeable to water, while aldosterone/angiotensin 2 work in areas permeable to water (A)</p> Signup and view all the answers

Why does the water channel approach not work in areas of the nephron that are permeable to water?

<p>Because water would already be able to follow salt through osmosis (C)</p> Signup and view all the answers

Study Notes

Angiotensin 2 Hormone

  • Angiotensin 2 is a small hormone consisting of 8 amino acids
  • It targets various organs and causes vasoconstriction in blood vessels
  • Vasoconstriction increases resistance, leading to increased blood pressure

Blood Vessel Target

  • Angiotensin 2 constricts smooth muscle in blood vessel walls, causing vasoconstriction
  • This increases resistance, which in turn increases blood pressure (delta P = Q x R)
  • The formula delta P = Q x R is useful in understanding how angiotensin 2 affects blood pressure
  • Increased resistance leads to increased arterial pressure, with little change in venous pressure

Kidney Target

  • Angiotensin 2 causes sodium reabsorption in the kidneys, leading to water reabsorption
  • This increases stroke volume, which in turn increases arterial blood pressure
  • The response in the kidneys is slower compared to the rapid response in blood vessels

Pituitary Gland Target

  • Angiotensin 2 stimulates the pituitary gland to release antidiuretic hormone (ADH)
  • ADH causes vasoconstriction and water reabsorption, leading to increased stroke volume and blood pressure
  • Water reabsorption differs from sodium reabsorption in its mechanism and effect on blood pressure

Adrenal Gland Target

  • Angiotensin 2 stimulates the adrenal gland to release aldosterone
  • Aldosterone causes sodium reabsorption in the kidneys, leading to water reabsorption and increased stroke volume
  • Sodium reabsorption also leads to increased blood pressure

Salt vs. Water Reabsorption

  • Both salt and water reabsorption increase stroke volume and blood pressure
  • Salt reabsorption works through osmosis, pulling water back into the bloodstream
  • Water reabsorption uses specialized channels to allow water to pass through
  • ADH uses water channels, while aldosterone and angiotensin 2 use salt reabsorption
  • The strategy used depends on the permeability of the nephron to water

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Learn about the targets of angiotensin 2, a small hormone composed of 8 amino acids, and its role in the body.

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