Angiogenesis and Anti-VEGF Drugs in Cancer Treatment
20 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What type of ECs provide a barrier to solutes and maintain bloodstream homeostasis?

  • Quiescent ECs (correct)
  • Anti-VEGF ECs
  • VEGF-resistant ECs
  • Pro-inflammatory ECs
  • Which mediator acts on post-capillary venules to increase microvascular permeability?

  • Epinephrine
  • Vascular endothelial growth factor (correct)
  • Glucagon
  • Insulin
  • What is the main determinant of microvascular permeability?

  • Pro-inflammatory mediators
  • Barrier properties of the endothelium (correct)
  • Anti-VEGF drugs
  • Microvascular endothelial cells
  • Which process involves ECs driving the formation of new blood vessels from existing ones?

    <p>Angiogenesis</p> Signup and view all the answers

    Which type of cells regulate vascular barrier function and control inflammation?

    <p>Endothelial cells</p> Signup and view all the answers

    What process is characterized by the sprouting of new lymphatic blood vessels?

    <p>Lymphangiogenesis</p> Signup and view all the answers

    Which system is involved in the regulation of lymphangiogenesis?

    <p>VEGF – VEGFRs</p> Signup and view all the answers

    Which drug would most likely inhibit the formation of new lymphatic vessels?

    <p>VEGF-B inhibitor</p> Signup and view all the answers

    Which signaling system is important in the process of angiogenesis and vasculogenesis?

    <p>Delta – Notch system</p> Signup and view all the answers

    In patients with VEGF resistance, what factor might be a contributing cause?

    <p>Hyperactivity of the Notch system</p> Signup and view all the answers

    How is myosin light chain dephosphorylation achieved?

    <p>Increasing MLCP activity</p> Signup and view all the answers

    In resistance vessels, what is the direct result of endothelial nitric oxide (NO) production?

    <p>Reduction in blood pressure</p> Signup and view all the answers

    Which type of cells regulate vascular function and integrity by forming a mono-cellular layer along the lumen of blood vessels?

    <p>Endothelial cells (ECs)</p> Signup and view all the answers

    What is involved in the pathogenesis of arteriosclerosis according to the text?

    <p>Phosphorylation of MYPT1 and MLC20</p> Signup and view all the answers

    Which process is Rho/ROCK signaling involved in according to the text?

    <p>Arteriosclerosis</p> Signup and view all the answers

    What is the main purpose of using anti-VEGF and anti-VEGFR drugs in cancer treatment?

    <p>To inhibit angiogenesis and restrict tumor growth</p> Signup and view all the answers

    What is a potential application of VEGF in medicine?

    <p>Maintenance of various tissues at physiological levels</p> Signup and view all the answers

    What is responsible for impaired neovessel formation in ischemic disease?

    <p>VEGF resistance</p> Signup and view all the answers

    What is a role of Notch signaling in VEGF resistance?

    <p>Conferring VEGF resistance and angiostasis</p> Signup and view all the answers

    What is the limitation of using VEGF gene therapy for critical limb ischemia?

    <p>It has failed in clinical trials</p> Signup and view all the answers

    More Like This

    Angiogenesis and Neovessel Formation
    15 questions
    Angiogenesis in Health and Disease
    12 questions
    Angiogenesis in Tumors and Development
    23 questions

    Angiogenesis in Tumors and Development

    MiraculousBildungsroman4805 avatar
    MiraculousBildungsroman4805
    Use Quizgecko on...
    Browser
    Browser