Angiogenesis and Anti-VEGF Drugs in Cancer Treatment

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What type of ECs provide a barrier to solutes and maintain bloodstream homeostasis?

Quiescent ECs (correct)

Anti-VEGF ECs

VEGF-resistant ECs

Pro-inflammatory ECs

Which mediator acts on post-capillary venules to increase microvascular permeability?

Epinephrine

Vascular endothelial growth factor (correct)

Glucagon

Insulin

What is the main determinant of microvascular permeability?

Pro-inflammatory mediators

Barrier properties of the endothelium (correct)

Anti-VEGF drugs

Microvascular endothelial cells

Which process involves ECs driving the formation of new blood vessels from existing ones?

Angiogenesis Signup and view all the answers

Which type of cells regulate vascular barrier function and control inflammation?

Endothelial cells Signup and view all the answers

What process is characterized by the sprouting of new lymphatic blood vessels?

Lymphangiogenesis Signup and view all the answers

Which system is involved in the regulation of lymphangiogenesis?

VEGF – VEGFRs Signup and view all the answers

Which drug would most likely inhibit the formation of new lymphatic vessels?

VEGF-B inhibitor Signup and view all the answers

Which signaling system is important in the process of angiogenesis and vasculogenesis?

Delta – Notch system Signup and view all the answers

In patients with VEGF resistance, what factor might be a contributing cause?

Hyperactivity of the Notch system Signup and view all the answers

How is myosin light chain dephosphorylation achieved?

Increasing MLCP activity Signup and view all the answers

In resistance vessels, what is the direct result of endothelial nitric oxide (NO) production?

Reduction in blood pressure Signup and view all the answers

Which type of cells regulate vascular function and integrity by forming a mono-cellular layer along the lumen of blood vessels?

Endothelial cells (ECs) Signup and view all the answers

What is involved in the pathogenesis of arteriosclerosis according to the text?

Phosphorylation of MYPT1 and MLC20 Signup and view all the answers

Which process is Rho/ROCK signaling involved in according to the text?

Arteriosclerosis Signup and view all the answers

What is the main purpose of using anti-VEGF and anti-VEGFR drugs in cancer treatment?

To inhibit angiogenesis and restrict tumor growth Signup and view all the answers

What is a potential application of VEGF in medicine?

Maintenance of various tissues at physiological levels Signup and view all the answers

What is responsible for impaired neovessel formation in ischemic disease?

VEGF resistance Signup and view all the answers

What is a role of Notch signaling in VEGF resistance?

Conferring VEGF resistance and angiostasis Signup and view all the answers

What is the limitation of using VEGF gene therapy for critical limb ischemia?

It has failed in clinical trials Signup and view all the answers