20 Questions
What type of ECs provide a barrier to solutes and maintain bloodstream homeostasis?
Quiescent ECs
Which mediator acts on post-capillary venules to increase microvascular permeability?
Vascular endothelial growth factor
What is the main determinant of microvascular permeability?
Barrier properties of the endothelium
Which process involves ECs driving the formation of new blood vessels from existing ones?
Angiogenesis
Which type of cells regulate vascular barrier function and control inflammation?
Endothelial cells
What process is characterized by the sprouting of new lymphatic blood vessels?
Lymphangiogenesis
Which system is involved in the regulation of lymphangiogenesis?
VEGF – VEGFRs
Which drug would most likely inhibit the formation of new lymphatic vessels?
VEGF-B inhibitor
Which signaling system is important in the process of angiogenesis and vasculogenesis?
Delta – Notch system
In patients with VEGF resistance, what factor might be a contributing cause?
Hyperactivity of the Notch system
How is myosin light chain dephosphorylation achieved?
Increasing MLCP activity
In resistance vessels, what is the direct result of endothelial nitric oxide (NO) production?
Reduction in blood pressure
Which type of cells regulate vascular function and integrity by forming a mono-cellular layer along the lumen of blood vessels?
Endothelial cells (ECs)
What is involved in the pathogenesis of arteriosclerosis according to the text?
Phosphorylation of MYPT1 and MLC20
Which process is Rho/ROCK signaling involved in according to the text?
Arteriosclerosis
What is the main purpose of using anti-VEGF and anti-VEGFR drugs in cancer treatment?
To inhibit angiogenesis and restrict tumor growth
What is a potential application of VEGF in medicine?
Maintenance of various tissues at physiological levels
What is responsible for impaired neovessel formation in ischemic disease?
VEGF resistance
What is a role of Notch signaling in VEGF resistance?
Conferring VEGF resistance and angiostasis
What is the limitation of using VEGF gene therapy for critical limb ischemia?
It has failed in clinical trials
Test your knowledge on the role of angiogenesis in tumor growth and the use of anti-VEGF drugs in cancer treatment. Explore the effectiveness and limitations of VEGF-A neutralizing antibodies and multi-kinase inhibitors in treating solid tumors.
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