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Anesthetics' Effects on Synaptic Transmission

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DauntlessShark9501
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15 Questions

What is the primary effect of anesthetics on neuronal activity?

Synaptic transmission

Which type of receptors are anesthetics thought to block?

Glutamatergic receptors

What is the effect of anesthetics on inhibitory synaptic transmission?

They enhance the function of inhibitory receptors

Which of the following neurotransmitters is associated with excitatory synaptic transmission?

Glutamate

What is the effect of anesthetics on cholinergic receptors?

They block cholinergic receptors

What is the primary site of action for anesthetics?

Synapses

What type of receptors are enhanced by anesthetics during inhibitory synaptic transmission?

GABA-A

Which of the following is NOT an excitatory receptor blocked by anesthetics?

GABA-A

What is the effect of anesthetics on TREK potassium channels?

Enhancement

What is the net effect of anesthetics on synaptic transmission?

Enhance inhibitory transmission

What is the net result of anesthetic action on synaptic transmission?

Depressed overall transmission

Which receptor type is anesthetic action thought to enhance?

GABA-A receptors

What is the primary neurotransmitter associated with inhibitory synaptic transmission?

GABA

Anesthetics are thought to block which type of receptors during excitatory synaptic transmission?

Serotonergic receptors

What are anesthetics thought to affect during inhibitory synaptic transmission?

GABA-A receptors

Study Notes

Anaesthetic Effects on Synaptic Transmission

  • Anaesthetics predominantly affect synaptic transmission, rather than action potential propagation.

Excitatory Synaptic Transmission

  • Anaesthetics block excitatory receptors, including:
    • Glutamatergic receptors
    • Cholinergic receptors
    • Serotonergic (5HT) receptors

Inhibitory Synaptic Transmission

  • Anaesthetics generally enhance the function of inhibitory synaptic receptors, including:
    • GABA-A receptors
    • TREK potassium channels

Anaesthetic Effects on Synaptic Transmission

  • Anaesthetics predominantly affect synaptic transmission, rather than action potential propagation.

Excitatory Synaptic Transmission

  • Anaesthetics block excitatory receptors, including:
    • Glutamatergic receptors
    • Cholinergic receptors
    • Serotonergic (5HT) receptors

Inhibitory Synaptic Transmission

  • Anaesthetics generally enhance the function of inhibitory synaptic receptors, including:
    • GABA-A receptors
    • TREK potassium channels

Anaesthetic Effects on Synaptic Transmission

  • Anaesthetics predominantly affect synaptic transmission, rather than action potential propagation.

Excitatory Synaptic Transmission

  • Anaesthetics block excitatory receptors, including:
    • Glutamatergic receptors
    • Cholinergic receptors
    • Serotonergic (5HT) receptors

Inhibitory Synaptic Transmission

  • Anaesthetics generally enhance the function of inhibitory synaptic receptors, including:
    • GABA-A receptors
    • TREK potassium channels

This quiz explores the impact of anesthetics on synaptic transmission, focusing on excitatory and inhibitory receptors. It covers the blocking of receptors like Glutamatergic, Cholinergic, and Serotonergic, and the enhancement of GABA-A receptors and TREK potassium channels.

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