Anesthetics and Dermatology Quiz

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Questions and Answers

You are about to give levobupivicaine, which is a local anaesthetic drug, for local wound infiltration to reduce postoperative pain after surgery. How do local anaesthetic drugs block pain signalling transmission?

  • Blocking K+ channels
  • Opening K+ channels
  • Blocking Na+ channels (correct)
  • Opening Na+ channels

Which of the following is typically recovered from the skin scraping of a patient with tinea infection?

  • Aspergillus fumigatus
  • Rhizopus microsporus
  • Microsporum canis (correct)
  • Cryptococcus neoformans

Infections by which of the following organisms is normally diagnosed by antibody testing rather than bacterial culture?

  • Shigella flexneri
  • Pseudomonas aeruginosa
  • Treponema pallidum (correct)
  • Klebsiella pneumoniae

Which group of parasites typically has an elongated and segmented appearance?

<p>Cestodes (D)</p> Signup and view all the answers

A 24-year-old male patient complains of a recent onset of purulent urethral discharge. What is the MOST LIKELY pathogen involved?

<p>Neisseria gonorrhoeae (D)</p> Signup and view all the answers

Which of the following host immune defects predisposes to tuberculosis?

<p>Defective T-lymphocyte production (B)</p> Signup and view all the answers

The dermis of the skin is made of two major protein fibres. What is the major protein which makes up the dermis of the skin?

<p>Collagen (A)</p> Signup and view all the answers

Hair growth occurs in a cycle. What is the average length of the anagen phase in hair growth?

<p>3 years (D)</p> Signup and view all the answers

There are different modes of secretion in the glandular epithelium. Which of the following glands is involved in apocrine secretion?

<p>Mammary gland (D)</p> Signup and view all the answers

Based on the images above, which epithelium is well suited to withstand increased wear and tear forces in the moist mucosal cavity such as the oral cavity?

<p>A = Stratified squamous epithelium B = Stratified cuboidal epithelium C = Stratified columnar epithelium D = Simple squamous epithelium</p> Signup and view all the answers

During oogenesis, female gamete cells progress through different stages of meiosis and form the primary, secondary and mature oocytes. At which stage of meiosis is the oocyte when it is ovulated?

<p>Metaphase of meiosis II (D)</p> Signup and view all the answers

Haemostasis is the process to stop bleeding. Which precursor blood cell gives rise to the formed elements responsible for haemostasis?

<p>Megakaryocyte (C)</p> Signup and view all the answers

There are different types of cells in the nervous system. Dysfunctional apical cilia of which type of cells may alter choroid plexus function and lead to hydrocephalus?

<p>Ependymal cells (C)</p> Signup and view all the answers

With reference to the image above, which organ is lined with this type of epithelium?

<p>Urinary bladder (A)</p> Signup and view all the answers

You are providing care for a family with a rare neurological disorder. A boy and a girl are affected and show very similar symptoms. Three other siblings and the biological parents are healthy. You suspect a monogenic disease. Which inheritance pattern would be the MOST PLAUSIBLE?

<p>Autosomal recessive (B)</p> Signup and view all the answers

In anaerobic cellular respiration, pyruvate is converted to lactate. Which of the following is required in the conversion?

<p>NADH (A)</p> Signup and view all the answers

In vitro fertilisation can help carriers of genetic diseases. Which reproductive technology leads to babies with genetic material from three individuals?

<p>Mitochondrial replacement (C)</p> Signup and view all the answers

Deficiency of vitamin C leads to scurvy. Vitamin C is required for which protein post-translational modification?

<p>Proline hydroxylation (B)</p> Signup and view all the answers

The mammalian cell cycle can be stopped at specific checkpoints when sensing unfavourable signals. When DNA replication is incomplete, the cell cycle arrests at which of the following checkpoints?

<p>G2 (C)</p> Signup and view all the answers

In aerobic cellular respiration, pyruvate is oxidised to form acetyl-CoA. Which of the following is also required in this reaction step?

<p>NAD+ (A)</p> Signup and view all the answers

Many diseases are associated with defects in RNA processing. In which cellular compartment does RNA processing mainly occur?

<p>Nucleus (C)</p> Signup and view all the answers

Single gene disorders often show a predictable 'Mendelian' inheritance pattern. Which pattern of affected individuals in a pedigree diagram would suggest an autosomal dominant inheritance?

<p>All generations are affected (C)</p> Signup and view all the answers

Vaccination offers long lasting antigen-specific immune protection. What is the key cellular mediator responsible for this protection?

<p>Memory lymphocytes (B)</p> Signup and view all the answers

The human body is made up of several fluid compartments. How do you calculate the intracellular fluid volume of the body?

<p>Total body fluid volume - plasma volume - interstitial fluid volume (A)</p> Signup and view all the answers

Vesicular transport moves materials into or out of a cell. What process describes the release of neurotransmitters at a chemical synapse?

<p>Exocytosis (A)</p> Signup and view all the answers

Calcium ions play an important role in excitation-contraction coupling. Which protein can be activated by calcium ions?

<p>Troponin (D)</p> Signup and view all the answers

The core body temperature is normally maintained at a relatively constant level by the thermoregulatory centre. What body response occurs when the core body temperature is below the thermal set-point of the thermoregulatory centre?

<p>Shivering (C)</p> Signup and view all the answers

Dr. Kwong has invented a new blood test for the diagnosis of a disease. What is the false negative rate of this new diagnostic test equivalent to?

<p>1-sensitivity of the test (B)</p> Signup and view all the answers

A test is positive in 60 out of 100 patients and 60 out of 100 normal individuals. What is the positive predictive value of this new test?

<p>0.50 (C)</p> Signup and view all the answers

A key part of the United Nations (UN) Sustainable Development Goals (SDG3) is to achieve universal health coverage (UHC). What is the target goal for achieving universal health coverage other than access to essential health services and medicines for all?

<p>Financial risk protection (C)</p> Signup and view all the answers

Drugs can be administrated by different routes. Each route has its specific purposes, advantages and disadvantages. Which of the following is a characteristic of parenteral route of administration?

<p>Subcutaneous injection can be given by the patients themselves (B)</p> Signup and view all the answers

Malabsorption of fructose may occur after large consumption of fruit juice. How does fructose get into blood from the small intestine?

<p>By simple diffusion (B)</p> Signup and view all the answers

A single motor neuron and its innervated muscle fibres constitute a motor unit. What physiological response is triggered in muscle fibres when the motor neuron is stimulated by a threshold stimulus?

<p>Recruitment of one motor unit (A)</p> Signup and view all the answers

Mental activities impact on human health. According to the "Zang-Fu" theory in Chinese Medicine, which emotion condition would affect the function of "the Liver?"

<p>Anger (B)</p> Signup and view all the answers

The innate immune system consists of humoral and cellular components. Which of the following cell types are present in the innate immune system?

<p>Macrophages (A)</p> Signup and view all the answers

During infections, many soluble factors mediate innate immunity against invading pathogens. Which of the following soluble factors is directly involved in innate immune response?

<p>Complement (A)</p> Signup and view all the answers

An intravenous drug addict was diagnosed to have disseminated tuberculosis. Which of the following would be the characteristic cell type seen in the biopsies that would be diagnostic of his condition?

<p>Langhans giant cells (C)</p> Signup and view all the answers

The innate immune system provides first-line defence mechanisms and consists of humoral and cellular components. Which of the following cellular components does it include?

<p>Neutrophils (C)</p> Signup and view all the answers

Phenytoin is a drug for treating epilepsy, and it is highly lipophilic. What would be the concern for an obese patient to use phenytoin?

<p>A delayed onset of drug action (D)</p> Signup and view all the answers

During implantation, the blastocyst is embedded into the maternal endometrium. Which cell layer plays the MOST ACTIVE role in invading the endometrium?

<p>Syncytiotrophoblast (D)</p> Signup and view all the answers

What types of collagen fibres contribute to layer X?

<p>Type III and IV (B)</p> Signup and view all the answers

What are the arrowed structures that help anchor epithelial cells to the underlying basal lamina?

<p>Hemidesmosomes (D)</p> Signup and view all the answers

Which formed element of blood contains helminthotoxic granules?

<p>B (D)</p> Signup and view all the answers

Which type of tissue is shown in the picture (arrowed)?

<p>Skeletal muscle (C)</p> Signup and view all the answers

Which type of cells shown in the picture (arrowed) lines the inner surface of the central canal of the spinal cord?

<p>Ependymal cells (A)</p> Signup and view all the answers

The mesoderm germ layer differentiates to form different structures of our body. Which of the following is derived from the intermediate mesoderm layer?

<p>Kidney (D)</p> Signup and view all the answers

Given the unique features of the skin in this slide, identify the specific region of the body from which this skin sample was obtained.

<p>Palm of the hand (D)</p> Signup and view all the answers

What is the arrowed structure?

<p>Duct of a sweat gland (C)</p> Signup and view all the answers

What is the predominant cell type in the outlined area?

<p>Fibroblasts (D)</p> Signup and view all the answers

The diagram showed a specimen of the external muscle layers of the middle 1/3 of the oesophagus. Which type of tissue is found in the circled area?

<p>Skeletal muscle (B)</p> Signup and view all the answers

Flashcards

How do local anaesthetic drugs block pain?

Local anaesthetic drugs block pain signalling transmission by binding to and blocking voltage-gated sodium channels in the cell membrane of nerve fibres, preventing the generation and conduction of nerve impulses.

What organism is typically found in tinea infection?

Microsporum canis is a common cause of tinea infections, a fungal infection of the skin, hair, and nails. It is usually transmitted through contact with infected animals, especially cats and dogs.

What is commonly used for diagnosing Treponema pallidum infection?

Treponema pallidum, the causative agent of syphilis, is a bacteria that is very difficult to grow in culture. Therefore, diagnosis relies on serological tests that detect antibodies produced by the body in response to the infection.

What parasite has a segmented appearance?

Cestodes, a type of parasitic flatworm, are characterized by their long, segmented bodies. These segments, known as proglottids, contain reproductive organs and are responsible for the transmission of the parasite's eggs.

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Most likely pathogen in purulent urethral discharge?

Neisseria gonorrhoeae, the bacteria that causes gonorrhea, is a common cause of purulent urethral discharge in males. This bacteria is typically transmitted through sexual contact and can cause infections in the urethra, cervix, rectum, throat, and eyes.

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Immune defect leading to tuberculosis?

A deficiency in T-lymphocyte production weakens the immune system's ability to control Mycobacterium tuberculosis, increasing the risk of developing tuberculosis.

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Major protein in the dermis?

Collagen is the main structural protein found in the dermis, providing strength and support to the skin. It forms a network of fibers that gives skin its elasticity and resilience.

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Average length of the anagen phase in hair growth?

The anagen phase of hair growth, also known as the growth phase, is typically very long, lasting for several years. During this phase, hair grows continuously.

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What gland is involved in apocrine secretion?

Mammary glands secrete milk through the process of apocrine secretion, which involves the release of a portion of the cell membrane along with the secreted product.

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Which epithelium withstands wear and tear?

Stratified squamous epithelium, found in the oral cavity, is well suited for withstanding wear and tear forces due to its multiple layers of cells and the presence of keratin in its surface layers.

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What stage of meiosis is the oocyte at ovulation?

At ovulation, the oocyte is released from the ovary in metaphase II of meiosis. It is arrested at this stage until fertilization occurs, when the second meiotic division is completed.

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What precursor cell gives rise to formed elements involved in haemostasis?

Megakaryocytes are large, multinucleated cells responsible for producing platelets, which are crucial for haemostasis (blood clotting) by forming a plug at the site of injury.

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What cell type has dysfunctional cilia in hydrocephalus?

Ependymal cells, which line the ventricles of the brain and the central canal of the spinal cord, have cilia that assist in the flow of cerebrospinal fluid (CSF). Dysfunctional cilia can lead to hydrocephalus, a build-up of CSF in the brain.

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What organ is lined with transitional epithelium?

The epithelium lining the urinary bladder is transitional epithelium, also known as urothelium. It can stretch and change shape, allowing the bladder to expand and contract as it fills with urine.

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Most plausible inheritance pattern in a family with two affected siblings?

Autosomal recessive inheritance pattern is the most plausible when both affected individuals share the same recessive allele from both parents. This pattern explains how two unaffected parents can have multiple affected children due to inheriting the recessive alleles.

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What is required in converting pyruvate to lactate?

NADH, which is a reduced form of nicotinamide adenine dinucleotide, is required for the conversion of pyruvate to lactate in anaerobic cellular respiration. This conversion regenerates NAD+ needed for glycolysis to continue in the absence of oxygen.

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Reproductive technology that uses genetic material from three individuals?

Mitochondrial replacement therapy (MRT), a reproductive technology, involves transferring the nuclear DNA of a fertilized egg into a donor egg that has normal mitochondria. This results in a baby with genetic material from three individuals.

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What is vitamin C required for?

Vitamin C is a coenzyme required for the hydroxylation of proline residues in collagen synthesis. This modification is essential for the strength and stability of collagen fibers.

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What checkpoint is activated when DNA replication is incomplete?

The G2 checkpoint ensures that DNA replication is complete and the cell is ready for mitosis. If DNA replication is incomplete, the cell cycle will be arrested at this checkpoint to prevent errors in chromosome segregation.

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What is required in the oxidation of pyruvate to acetyl-CoA?

NAD+, which is an oxidized form of nicotinamide adenine dinucleotide, is required in the oxidation of pyruvate to form acetyl-CoA. This reaction is a key step in aerobic cellular respiration, where pyruvate is converted into a form that can enter the citric acid cycle.

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Where does RNA processing occur?

RNA processing, which includes capping, splicing, and polyadenylation, mainly takes place in the nucleus of the cell. This ensures that the mRNA transcript is properly modified and prepared for translation.

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Inheritance pattern with affected individuals in all generations?

Autosomal dominant inheritance pattern is characterized by affected individuals in all generations of a family. Affected individuals usually have at least one affected parent.

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Key cellular mediator in long-lasting immune protection?

Memory lymphocytes, also known as memory B cells and memory T cells, are responsible for long-lasting antigen-specific immune protection after vaccination. These cells can quickly recognize and mount an immune response against the same pathogen in the future.

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How to calculate intracellular fluid volume?

Intracellular fluid volume (ICF) is calculated by subtracting the total volume of extracellular fluid (ECF) from the total body fluid volume (TBFV). This formula considers that the total body fluid is divided into ICF and ECF components.

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What process describes neurotransmitter release at a chemical synapse?

Exocytosis is the process by which neurotransmitters are released from the presynaptic neuron into the synaptic cleft. This release of neurotransmitters allows communication between neurons across synapses.

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What protein is activated by calcium ions in muscle contraction?

Troponin, a protein complex found in skeletal and cardiac muscle, is activated by calcium ions. This activation triggers the movement of tropomyosin, allowing myosin to bind to actin and initiate muscle contraction.

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What body response occurs when core body temperature is below the set-point?

Shivering, a mechanism to increase heat production in response to a drop in core body temperature, involves involuntary muscle contractions that generate heat. This response helps restore the body's core temperature to the set-point.

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False negative rate of a diagnostic test?

The false negative rate of a diagnostic test is equal to 1 - sensitivity of the test. Sensitivity indicates the test's ability to correctly identify individuals with the disease.

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What is positive predictive value?

The positive predictive value (PPV) is the probability that a positive test result accurately indicates the presence of the disease. In this scenario, PPV is 0.50, meaning 50% of individuals with a positive test actually have the disease.

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Target goal for achieving universal health coverage?

Financial risk protection, a key aspect of universal health coverage, ensures that people can access healthcare without facing financial hardship. This includes protecting individuals from catastrophic health expenses and promoting equitable access to healthcare.

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What is a characteristic of parenteral drug administration?

The parenteral route of administration involves injecting drugs directly into the body, bypassing the gastrointestinal tract. Subcutaneous injections are given under the skin and can be self-administered by patients.

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How does fructose get into blood from the small intestine?

Fructose enters the blood from the small intestine through the action of glucose transporters. These transporters facilitate the movement of fructose across the cell membrane and into the bloodstream.

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What physiological response is triggered in a muscle fibre when a motor neuron is stimulated?

When a motor neuron is stimulated with a threshold stimulus, it triggers the contraction of a single motor unit, which consists of a single motor neuron and its innervated muscle fibres. This contraction is a basic unit of muscle activity.

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What emotion is associated with the Liver in Chinese medicine?

In Chinese medicine, the Liver is associated with the emotion of anger. According to the

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What cell type is part of the innate immune system?

Macrophages are phagocytic cells that are part of the innate immune system. They recognize and engulf pathogens, presenting their antigens to T cells to initiate adaptive immune responses.

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What soluble factor is directly involved in innate immune response?

Complement is a group of proteins that acts as a part of the innate immune system. Upon activation, they trigger a cascade of events leading to pathogen lysis, inflammation, and opsonization.

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What cell type is diagnostic of tuberculosis?

Langhans giant cells, which are multinucleated cells, are characteristically found in granulomas associated with Mycobacterium tuberculosis infections. These cells are formed by the fusion of macrophages.

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What cellular component of the innate immune system is involved in pathogen destruction?

Neutrophils, which are phagocytic cells, are also part of the innate immune system. They are the first responders to infection and actively engulf and destroy pathogens.

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Study Notes

Table of Contents

  • Section A: Multiple Choice Questions (3 pages)
  • Section A: Extended Matching Questions (3 pages)
  • Section A: Structured Answer Questions (3 pages)
  • Section B: Multiple Choice Questions (3 pages)
  • Section B: Extended Matching Questions (3 pages)
  • Section B: Structured Answer Questions (3 pages)

Multiple Choice Questions (Section A)

  • Levobupivicaine, a local anesthetic, blocks pain signaling by blocking sodium channels.
  • A skin scraping for tinea infection typically reveals dermatophytes such as Microsporum canis.
  • Cestodes have an elongated and segmented appearance.
  • Neisseria gonorrhoeae is the most likely pathogen for purulent urethral discharge in a 24-year-old male.
  • Defective T-lymphocyte production is a host immune defect that predisposes to tuberculosis.
  • Collagen is the major protein fiber in the dermis of the skin.
  • The anagen phase of hair growth lasts approximately 3 years.
  • Apocrine secretion is associated with mammary glands.
  • Stratified squamous epithelium is well suited for the oral cavity due to its strength and resilience to wear and tear, and its resistance to moisture damage.
  • Oocytes are ovulated in metaphase II of meiosis.
  • Haemostasis is triggered by megakaryocytes, precursors to platelets.
  • Ependymal cells within the nervous system have apical cilia, whose dysfunction may lead to hydrocephalus.
  • Urinary bladder epithelium is stratified.
  • Autosomal recessive inheritance is the most likely pattern for a family with a rare neurological disorder where two siblings are affected while their parents and other siblings are healthy.
  • Pyruvate is converted to lactate in anaerobic respiration, requiring $NAD^+$.
  • In-vitro fertilization using mitochondrial replacement technology involves using genetic material from three individuals.
  • Vitamin C deficiency leads to scurvy, because vitamin C is required for the post-translational modification of proline hydroxylation, which is vital for the production of collagen.
  • The cell cycle stops at the G2 checkpoint when DNA replication is incomplete.
  • Electron transport chain occurs in the mitochondrion, needing $NAD^+$ for conversion of pyruvate to acetyl CoA.
  • Single-gene disorders follow a predictable Mendelian inheritance pattern.
  • The key cellular component for long-lasting antigen-specific immune protection from vaccines is memory lymphocytes.
  • Extracellular fluid and interstitial fluid make up total body fluid. To find intracellular fluid, deduct plasma and interstitial fluid volumes from total body fluid.
  • Exocytosis is the process where neurotransmitters are released.
  • Calcium ions activate troponin, a protein involved in excitation-contraction coupling.
  • A false negative rate is equivalent to 1 minus the sensitivity of the test.
  • A positive test in 60 of 100 patients and 60 of 100 normal individuals has a positive predictive value of 0.50.
  • Universal health coverage in the UN's sustainable development goals focuses on health system improvements and financial risk protection besides access to essential healthcare services.
  • Intramuscular and intravenous administrations (parenteral routes) are not self-administerable, whereas subcutaneous administrations are.
  • The anagen phase of hair growth lasts approximately 3 months, not 3 years.
  • Glucose transport in the small intestine is typically facilitated by glucose transporters (not simple diffusion).
  • A threshold stimulus in a motor unit triggers recruitment of one motor unit—not all.
  • Mental activities impact human health. According to the "Zang-Fu" theory in Chinese Medicine, anger affects the Liver.
  • Complement is part of the innate immune system, and are the soluble factors involved in innate immune responses.
  • The innate immune system involves neutrophils, macrophages, and natural killer cells.
  • Lipophilic drugs (like phenytoin) may have to be administered with caution to obese patients to prevent accumulation and toxicity due to their high rate of fat storage.
  • Cytotrophoblast layer is the most active in invading the endometrium during implantation.
  • Type III and IV collagen contribute to layer X in the tracheal epithelium.
  • Hemidesmosomes anchor epithelial cells to the underlying basal lamina.
  • The formed element of blood containing helminthotoxic granules is eosinophils.
  • The tissue in the circled area of a middle-1/3 oesophagus specimen is skeletal muscle tissue.
  • Bipolar, multipolar, pseudounipolar neurons are present in cerebral cortex specimen.
  • Satellite glial cells are present in sympathetic ganglion specimens.
  • Intermediate mesoderm gives rise to the kidneys.

Multiple Choice Questions (Section B)

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