Anesthesia: Pharmacology and Physiology
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Questions and Answers

What is a characteristic of the drug formulation mentioned in the passage?

  • Oil-based formulation
  • Fat-soluble formulation
  • Protein-bound formulation
  • Water-soluble formulation (correct)

Where does the drug enter the systemic circulation?

  • Systemic circulation
  • Pulmonary circulation
  • Left side of the heart (correct)
  • Right side of the heart

What determines the transfer of the drug from the blood to the brain?

  • Degree of unionization of the drug
  • Lipid insolubility of the drug
  • Arterial concentration of the free drug (correct)
  • Arterial concentration of bound drug

Why do highly lipid soluble drugs get initially distributed to organs with high blood flow?

<p>Because they have high blood flow (B)</p> Signup and view all the answers

What happens to the plasma concentration of the drug over time?

<p>It falls (B)</p> Signup and view all the answers

What is the result of redistribution on the action of the drug?

<p>It terminates the action of the drug (B)</p> Signup and view all the answers

What is a disadvantage of this anesthetic?

<p>Poor analgesic (D)</p> Signup and view all the answers

What is a benefit of using this anesthetic in patients with cerebral edema?

<p>It reduces intracranial tension (C)</p> Signup and view all the answers

Why must equipment for controlled ventilation be available when using this anesthetic?

<p>Pharyngeal and laryngeal reflexes persist (B)</p> Signup and view all the answers

What is a precaution that must be taken when administering this anesthetic?

<p>The patient should not be in a sitting position (D)</p> Signup and view all the answers

What is a possible complication of extravasation of this anesthetic?

<p>Nerve palsy and limb gangrene (B)</p> Signup and view all the answers

What is a benefit of using this anesthetic in patients with cerebral blood flow and metabolism?

<p>It reduces cerebral blood flow and metabolism (C)</p> Signup and view all the answers

What is the precaution to be taken when using propofol in patients with a history of egg allergy?

<p>History of egg allergy is not a contraindication (C)</p> Signup and view all the answers

In which age group is propofol infusion not recommended for long-term use?

<p>Children &lt; 16 years (A)</p> Signup and view all the answers

What is the advantage of etomidate in patients with cardiac disease?

<p>It is the most cardiovascular stable among all IV agents (D)</p> Signup and view all the answers

What is the most common adverse effect of etomidate?

<p>Nausea and vomiting (D)</p> Signup and view all the answers

What can be used to reduce the risk of adrenocortical suppression caused by etomidate?

<p>Vitamin C supplementation (D)</p> Signup and view all the answers

What is the unique feature of etomidate that makes it useful in patients with elevated ICT?

<p>It decreases ICT by almost 50% (C)</p> Signup and view all the answers

What can barbiturate poisoning lead to?

<p>Death (D)</p> Signup and view all the answers

Why are barbiturates contraindicated in patients with acute intermittent porphyria?

<p>They can induce the production of hepatic Aminolevulinic acid (ALA) synthase (C)</p> Signup and view all the answers

What is the purpose of forced diuresis and alkalinisation of the urine in treating barbiturate poisoning?

<p>To increase the excretion of phenobarbital (A)</p> Signup and view all the answers

What is a common problem associated with the injection of propofol?

<p>Pain on injection (A)</p> Signup and view all the answers

Why is it mandatory to discard the propofol vial within 6 hours after opening?

<p>To prevent bacterial contamination (B)</p> Signup and view all the answers

What is the concentration of propofol available as a milky white solution?

<p>1% and 2% (D)</p> Signup and view all the answers

What is a primary function of gamma-aminobutyric acid (GABA) in the central nervous system?

<p>To reduce neuronal excitability (B)</p> Signup and view all the answers

Which of the following is NOT a use of benzodiazepines in anesthesia?

<p>Analgesia (D)</p> Signup and view all the answers

What is the mechanism of action of benzodiazepines?

<p>Potentiation of GABA actions (B)</p> Signup and view all the answers

Which route of administration is NOT used for lorazepam?

<p>Topical (C)</p> Signup and view all the answers

What is the elimination half-life of midazolam?

<p>2-3 hours (A)</p> Signup and view all the answers

Why are benzodiazepines used to prevent hallucinations by ketamine?

<p>Because they have amnesic properties (A)</p> Signup and view all the answers

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