Anemia Types and Characteristics
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Questions and Answers

Which of the following is a characteristic feature of microangiopathic hemolytic anemia (MAHA)?

  • Spherocytes
  • Prolonged severity
  • Presence of Heinz bodies
  • Schistocytes (correct)
  • What is a potential cause of MAHA?

  • Autoimmune hemolytic anemia (AIHA)
  • Neonatal jaundice
  • Disseminated intravascular coagulation (DIC) (correct)
  • Congenital Spherocytes
  • What is a potential cause of Heinz bodies?

  • Autoimmune hemolytic anemia (AIHA)
  • G6PD deficiency (correct)
  • Artificial heart valve
  • Thrombotic thrombocytopenic purpura (TTP)
  • Which of the following is a potential cause of acute hemolytic anemia?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic feature of hemolytic anemia?

    <p>Increased white blood cell count (B)</p> Signup and view all the answers

    Which of the following is a potential cause of hemolytic anemia?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is associated with neonatal jaundice?

    <p>All of the above (D)</p> Signup and view all the answers

    What is a potential cause of prolonged severity of hemolytic anemia?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the relationship between MAHA and TTP?

    <p>TTP is a rare cause of MAHA (C)</p> Signup and view all the answers

    What is the mechanism of hemolysis in MAHA?

    <p>Red blood cells are ripped apart by small blood clots (C)</p> Signup and view all the answers

    Which of the following is NOT a type of red blood cell that can be seen in MAHA?

    <p>Spherocyte (D)</p> Signup and view all the answers

    What is the most accurate description of the type of anemia observed in a patient presenting with hypochromic microcytic anemia?

    <p>Anemia characterized by small, pale red blood cells (C)</p> Signup and view all the answers

    Which of the following diagnostic tests is NOT typically used to assess for hypochromic microcytic anemia?

    <p>Complete Blood Count (CBC) with a reticulocyte count (B)</p> Signup and view all the answers

    A patient with hypochromic microcytic anemia presents with a low serum iron level and an elevated TIBC. What is the most likely explanation for these findings?

    <p>Iron deficiency due to insufficient dietary intake (A)</p> Signup and view all the answers

    What is a key feature of the red blood cells in hypochromic microcytic anemia, typically observed under a microscope?

    <p>Presence of target cells (A)</p> Signup and view all the answers

    Which of the following is NOT a common symptom of hypochromic microcytic anemia?

    <p>Headache (A)</p> Signup and view all the answers

    What is the most likely cause of hypochromic microcytic anemia in a patient presenting with chronic kidney disease?

    <p>Iron deficiency due to impaired erythropoietin production (A)</p> Signup and view all the answers

    A patient diagnosed with hypochromic microcytic anemia presents with elevated serum ferritin levels and a normal TIBC. What is the most plausible explanation for these findings?

    <p>Iron overload due to genetic mutations (A)</p> Signup and view all the answers

    What is a key difference between hypochromic microcytic anemia due to iron deficiency and that due to thalassemia?

    <p>Thalassemia is primarily a genetic disorder (A)</p> Signup and view all the answers

    In hypochromic microcytic anemia, what is the primary mechanism that leads to the reduced red blood cell size (microcytosis)?

    <p>Decreased hemoglobin synthesis (B)</p> Signup and view all the answers

    Which of the following is NOT a common laboratory finding observed in a patient with hypochromic microcytic anemia?

    <p>Elevated reticulocyte count (B)</p> Signup and view all the answers

    A patient presents with hypochromic microcytic anemia and elevated levels of HbF (fetal hemoglobin) and HbA2 (adult hemoglobin). What is the most likely diagnosis?

    <p>Thalassemia minor (D)</p> Signup and view all the answers

    A patient with hypochromic microcytic anemia undergoes a bone marrow aspiration. The examination reveals an increased number of sideroblasts (red blood cell precursors with iron granules). What is the most likely diagnosis?

    <p>Sideroblastic anemia (A)</p> Signup and view all the answers

    What is the most appropriate treatment for a patient diagnosed with hypochromic microcytic anemia due to iron deficiency?

    <p>Iron supplementation (D)</p> Signup and view all the answers

    A patient with hypochromic microcytic anemia is found to have a history of excessive alcohol consumption. What is the most likely cause of the anemia in this patient?

    <p>Sideroblastic anemia due to alcohol-induced toxicity (C)</p> Signup and view all the answers

    A patient with hypochromic microcytic anemia is diagnosed with a genetic mutation in the CAIAS2 gene. What is the most likely underlying cause of their anemia?

    <p>Sideroblastic anemia due to a genetic defect (B)</p> Signup and view all the answers

    In a patient with Warm AIHA, which of the following is NOT a likely laboratory finding?

    <p>Increased serum iron (D)</p> Signup and view all the answers

    Which of these is the MOST likely reason for spherocytes seen in Warm AIHA?

    <p>Immune-mediated destruction by antibodies (A)</p> Signup and view all the answers

    What is a distinguishing characteristic of Cold agglutinin disease (Cold AIHA) compared to Warm AIHA?

    <p>Positive DAT with IgM antibodies (C)</p> Signup and view all the answers

    In a patient with untreated Megaloblastic anemia, what is the primary cause of the macro-ovalocytes?

    <p>Defective DNA synthesis in red blood cells (A)</p> Signup and view all the answers

    What is the MOST likely reason for hypersegmented neutrophils seen in a patient with Megaloblastic anemia?

    <p>Impaired DNA synthesis in neutrophils (B)</p> Signup and view all the answers

    Which of these is a typical characteristic of Acute Leukemia that distinguishes it from Chronic Leukemia?

    <p>Presence of blasts (D)</p> Signup and view all the answers

    In a patient suspected of having Acute Lymphoblastic Leukemia, what are the MOST prominent characteristics of the lymphoblasts?

    <p>Small, condensed nuclear chromatin (D)</p> Signup and view all the answers

    What is the MOST accurate statement regarding the Peroxidase test in the differentiation of Leukemia?

    <p>Positive in myeloblastic leukemia, negative in lymphoblastic leukemia (C)</p> Signup and view all the answers

    Which of the following conditions is LEAST likely to present with splenomegaly?

    <p>Acute Lymphoblastic Leukemia (D)</p> Signup and view all the answers

    Which of the following is a CORRECT association between the specific type of antibody and the corresponding type of AIHA?

    <p>IgM antibodies - Cold AIHA (D)</p> Signup and view all the answers

    Which of the following is a defining characteristic of Erythroid Maturation in both acute and chronic leukemia?

    <p>Presence of blasts in the bone marrow (C)</p> Signup and view all the answers

    What statement CORRECTLY describes the relationship between antibody type and DAT findings in Warm AIHA?

    <p>IgG antibodies cause a positive DAT in Warm AIHA (B)</p> Signup and view all the answers

    Which of these BEST describes the role of the spleen in Warm AIHA?

    <p>The spleen destroys red blood cells that are coated with antibodies (A)</p> Signup and view all the answers

    Which of these LABORATORY findings is MOST characteristic of a patient with severe Megaloblastic anemia?

    <p>Decreased white blood cell count (WBC) (B)</p> Signup and view all the answers

    Which of these is NOT a common clinical feature of Warm AIHA?

    <p>Elevated liver enzymes (B)</p> Signup and view all the answers

    What is the MOST likely reason for the presence of basophilic stippling in red blood cells in Megaloblastic anemia?

    <p>Impaired DNA synthesis (A)</p> Signup and view all the answers

    Flashcards

    Hemolytic Anemia

    A condition where red blood cells are destroyed faster than they can be made.

    Heinz Bodies

    Aggregates of denatured hemoglobin found in red blood cells during hemolytic anemia.

    Microangiopathic Hemolytic Anemia

    A type of hemolytic anemia caused by small blood vessel damage.

    Thrombotic Thrombocytopenic Purpura (TTP)

    A rare blood disorder leading to the formation of small clots in blood vessels.

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    Disseminated Intravascular Coagulation (DIC)

    A serious disorder in which blood clots form throughout the body's small blood vessels.

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    Spherocytes

    Abnormally shaped red blood cells that are spherical instead of biconcave, often seen in hemolytic anemia.

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    Acute Hemolytic Anemia

    Rapid destruction of red blood cells leading to anemia, often following transfusion reactions.

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    Artificial Heart Valve

    A medical device used to replace a damaged heart valve which can cause red blood cell destruction.

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    Schistocyte

    A fragmented red blood cell, often seen in conditions like hemolytic anemia and DIC.

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    Congenital Hemolytic Anemia

    Inherited conditions that cause the premature destruction of red blood cells.

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    Warm AIHA

    Autoimmune hemolytic anemia occurring at body temperature.

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    Positive DAT

    Direct Antiglobulin Test, indicating antibodies attached to RBCs.

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    Cold AIHA

    Autoimmune hemolytic anemia that occurs at lower temperatures.

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    Megaloblastic Anemia

    Macrocytic anemia due to Vitamin B12 or folic acid deficiency.

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    Macrocytic Anemia

    Anemia characterized by larger than normal red blood cells.

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    Intrinsic Factor

    A protein necessary for Vitamin B12 absorption in the intestine.

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    Reticulocytes

    Immature red blood cells often elevated in anemia.

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    Hypersegmented Neutrophils

    Neutrophils with more than five nuclear lobes, seen in megaloblastic anemia.

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    IDA

    Iron Deficiency Anemia, a common type of microcytic anemia.

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    Acute Myeloid Leukemia (AML)

    A type of cancer that affects the blood and bone marrow, characterized by the rapid growth of myeloid cells.

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    Lymphoblastic Leukemia

    Cancer of the blood and bone marrow characterized by lymphoblasts.

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    Bone Marrow Hypercellularity

    An increase in cell numbers in the bone marrow, often seen in hematologic disorders.

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    Anisocytosis

    Presence of red blood cells of unequal size, often a sign of anemia.

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    Hypochromic Microcytic Anemia

    Anemia characterized by low MCH and MCV, often due to iron deficiency.

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    MCH

    Mean corpuscular hemoglobin; measures the average amount of hemoglobin per RBC.

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    MCV

    Mean corpuscular volume; indicates average size of red blood cells.

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    Serum Iron

    Measures the amount of circulating iron in the blood.

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    Ferritin

    A protein that stores iron; low levels indicate depleted iron stores.

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    TIBC

    Total iron-binding capacity; high levels indicate iron deficiency.

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    Anemia of Chronic Disease

    Anemia associated with chronic infections or inflammation.

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    Sideroblastic Anemia

    Anemia due to impaired heme synthesis, leading to iron overload.

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    Intrinsic Hemolytic Anemia

    Anemia due to defects within the red blood cells.

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    Sickle Cell Anemia

    Genetic disorder causing misshaped red blood cells, leading to blockage and pain.

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    Reticulocyte Count

    A measure of immature red blood cells; reflects bone marrow activity.

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    GGPD Deficiency

    An inherited condition where red blood cells break down prematurely due to enzyme lack.

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    Jaundice

    Yellowing of skin and eyes caused by high bilirubin due to hemolysis.

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    Splenomegaly

    Enlargement of the spleen; often due to increased RBC destruction.

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    Study Notes

    Hypochromic Microcytic Anemia

    • Key features:
      • Mean corpuscular hemoglobin (MCH) is low (<32 g/dL)
      • Mean corpuscular volume (MCV) is low (<80 fL)

    Iron Deficiency Anemia

    • Most common type of hypochromic microcytic anemia
    • Symptoms: Fatigue, pallor, brittle nails, pica (craving non-food items like ice)
    • Serum iron, ferritin, and transferrin receptor are affected
    • Bone marrow iron stores are decreased
    • Erythroblast iron is decreased

    Anemia of Chronic Disorder

    • Serum iron, ferritin and transferrin receptor are affected
    • Bone Marrow iron stores are reduced/normal.
    • Cause: chronic infection, inflammation, rheumatoid arthritis

    Sideroblastic Anemia

    • Serum iron and ferritin are elevated (iron overload)
    • Transferrin is reduced
    • % Transferrin saturation is elevated (body has too much iron)
    • TIBC is normal
    • Cause: genetic or acquired (alcoholism, pyridoxine deficiency, lead poisoning, isoniazid, chloramphenicol)

    Thalassemia, Abnormal Hemoglobin

    • Often have normal or slightly elevated serum iron and ferritin
    • Low MCH, MCV
    • Haemoglobin studies (HbF/HbA2) are abnormal

    Thalassemia Minor

    • Ferritin, Serum iron and transferrin are normal or elevated.
    • TIBC normal
    • Transferrin saturation slightly abnormal

    Hemolytic Anemia

    • Increased reticulocytes
    • Intrinsic causes: defects in red blood cell membranes, enzymes
    • Extrinsic causes: immune mechanisms, mechanical damage, infections

    Non-Hemolytic Normochromic Normocytic Anemia

    • Normal MCV (80-100 fL)
    • Non-hemoglobinopathy anemias
    • Causes: Iron deficiency, chronic disease, chronic kidney disease, aplastic anemia

    Intrinsic Haemolytic Anemia

    • Clinical Features: fluctuating jaundice, splenomegaly, pigment gallstones
    • Cause: hereditary spherocytosis, hereditary elliptocytosis, G6PD deficiency

    Microangiopathic Haemolytic Anemia (MAHA)

    • Fragmented red blood cells (schistocytes, helmet cells)
    • Cause: Disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), artificial heart valve

    Autoimmune Haemolytic Anemia (AIHA)

    • Warm AIHA: Splenomegaly, spherocytes increase MCHC.
    • Cold AIHA: Skin manifestations, acrocyanosis

    Megaloblastic Anemia

    • MCV > 100 fL
    • Insufficient nuclear DNA Synthesis (lack of vitamin B12/folate)
    • Large RBC due to continued hemoglobin production.
    • Oval morphology (macro-ovalocytes)
    • Symptoms: Fatigue, headache, palpitations, dyspnea, gray hair
    • Lab findings: increased LDH, indirect bilirubin, haptoglobin
    • Causes: Lack of intrinsic factor, destruction of gastric parietal cells, anti-gastric parietal cell auto antibodies

    Blast Cells

    • Erythroid maturation: Proerythroblast, Basophilic erythroblast, polychromatophilic erythroblast, orthochromatic erythroblast, reticulocytes, erythrocyte
    • Granulocytic maturation: Myeloblast, promyelocyte, myelocyte, metamyelocyte, neutrophil, band neutrophil
    • Lymphocytic Leukemia/Lymphoma: Lymphoblasts, (small, condensed nuclear chromatin, small nucleoli, scant agranular cytoplasm)
    • Acute myeloid leukaemia (AML): Myeloblasts, (delicate nuclear chromatin, prominent nucleoli, fine azurophilic cytoplasmic granules)

    Leukemia

    • Acute vs chronic: differing onset and dominance of cell types
    • Myeloid vs lymphoid: affecting different hematopoietic cell lineages
      • Acute myeloid leukemia (AML): immature myeloid blasts
      • Chronic myeloid leukemia (CML): mature myeloid cells
      • Acute lymphoblastic leukemia (ALL): immature lymphoid blasts
      • Chronic lymphocytic leukemia (CLL): mature lymphoid cells
    • Diagnostics include blood smears, bone marrow biopsies and immunologic tests

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    Anemia & Leukemia PDF

    Description

    This quiz explores various types of anemia, including hypochromic microcytic anemia, iron deficiency anemia, anemia of chronic disorder, and sideroblastic anemia. Understand key features, symptoms, and underlying causes of each type to enhance your knowledge in hematology.

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