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Questions and Answers
Which of the following is a characteristic feature of microangiopathic hemolytic anemia (MAHA)?
Which of the following is a characteristic feature of microangiopathic hemolytic anemia (MAHA)?
What is a potential cause of MAHA?
What is a potential cause of MAHA?
What is a potential cause of Heinz bodies?
What is a potential cause of Heinz bodies?
Which of the following is a potential cause of acute hemolytic anemia?
Which of the following is a potential cause of acute hemolytic anemia?
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Which of the following is NOT a characteristic feature of hemolytic anemia?
Which of the following is NOT a characteristic feature of hemolytic anemia?
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Which of the following is a potential cause of hemolytic anemia?
Which of the following is a potential cause of hemolytic anemia?
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Which of the following is associated with neonatal jaundice?
Which of the following is associated with neonatal jaundice?
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What is a potential cause of prolonged severity of hemolytic anemia?
What is a potential cause of prolonged severity of hemolytic anemia?
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What is the relationship between MAHA and TTP?
What is the relationship between MAHA and TTP?
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What is the mechanism of hemolysis in MAHA?
What is the mechanism of hemolysis in MAHA?
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Which of the following is NOT a type of red blood cell that can be seen in MAHA?
Which of the following is NOT a type of red blood cell that can be seen in MAHA?
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What is the most accurate description of the type of anemia observed in a patient presenting with hypochromic microcytic anemia?
What is the most accurate description of the type of anemia observed in a patient presenting with hypochromic microcytic anemia?
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Which of the following diagnostic tests is NOT typically used to assess for hypochromic microcytic anemia?
Which of the following diagnostic tests is NOT typically used to assess for hypochromic microcytic anemia?
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A patient with hypochromic microcytic anemia presents with a low serum iron level and an elevated TIBC. What is the most likely explanation for these findings?
A patient with hypochromic microcytic anemia presents with a low serum iron level and an elevated TIBC. What is the most likely explanation for these findings?
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What is a key feature of the red blood cells in hypochromic microcytic anemia, typically observed under a microscope?
What is a key feature of the red blood cells in hypochromic microcytic anemia, typically observed under a microscope?
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Which of the following is NOT a common symptom of hypochromic microcytic anemia?
Which of the following is NOT a common symptom of hypochromic microcytic anemia?
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What is the most likely cause of hypochromic microcytic anemia in a patient presenting with chronic kidney disease?
What is the most likely cause of hypochromic microcytic anemia in a patient presenting with chronic kidney disease?
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A patient diagnosed with hypochromic microcytic anemia presents with elevated serum ferritin levels and a normal TIBC. What is the most plausible explanation for these findings?
A patient diagnosed with hypochromic microcytic anemia presents with elevated serum ferritin levels and a normal TIBC. What is the most plausible explanation for these findings?
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What is a key difference between hypochromic microcytic anemia due to iron deficiency and that due to thalassemia?
What is a key difference between hypochromic microcytic anemia due to iron deficiency and that due to thalassemia?
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In hypochromic microcytic anemia, what is the primary mechanism that leads to the reduced red blood cell size (microcytosis)?
In hypochromic microcytic anemia, what is the primary mechanism that leads to the reduced red blood cell size (microcytosis)?
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Which of the following is NOT a common laboratory finding observed in a patient with hypochromic microcytic anemia?
Which of the following is NOT a common laboratory finding observed in a patient with hypochromic microcytic anemia?
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A patient presents with hypochromic microcytic anemia and elevated levels of HbF (fetal hemoglobin) and HbA2 (adult hemoglobin). What is the most likely diagnosis?
A patient presents with hypochromic microcytic anemia and elevated levels of HbF (fetal hemoglobin) and HbA2 (adult hemoglobin). What is the most likely diagnosis?
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A patient with hypochromic microcytic anemia undergoes a bone marrow aspiration. The examination reveals an increased number of sideroblasts (red blood cell precursors with iron granules). What is the most likely diagnosis?
A patient with hypochromic microcytic anemia undergoes a bone marrow aspiration. The examination reveals an increased number of sideroblasts (red blood cell precursors with iron granules). What is the most likely diagnosis?
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What is the most appropriate treatment for a patient diagnosed with hypochromic microcytic anemia due to iron deficiency?
What is the most appropriate treatment for a patient diagnosed with hypochromic microcytic anemia due to iron deficiency?
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A patient with hypochromic microcytic anemia is found to have a history of excessive alcohol consumption. What is the most likely cause of the anemia in this patient?
A patient with hypochromic microcytic anemia is found to have a history of excessive alcohol consumption. What is the most likely cause of the anemia in this patient?
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A patient with hypochromic microcytic anemia is diagnosed with a genetic mutation in the CAIAS2 gene. What is the most likely underlying cause of their anemia?
A patient with hypochromic microcytic anemia is diagnosed with a genetic mutation in the CAIAS2 gene. What is the most likely underlying cause of their anemia?
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In a patient with Warm AIHA, which of the following is NOT a likely laboratory finding?
In a patient with Warm AIHA, which of the following is NOT a likely laboratory finding?
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Which of these is the MOST likely reason for spherocytes seen in Warm AIHA?
Which of these is the MOST likely reason for spherocytes seen in Warm AIHA?
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What is a distinguishing characteristic of Cold agglutinin disease (Cold AIHA) compared to Warm AIHA?
What is a distinguishing characteristic of Cold agglutinin disease (Cold AIHA) compared to Warm AIHA?
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In a patient with untreated Megaloblastic anemia, what is the primary cause of the macro-ovalocytes?
In a patient with untreated Megaloblastic anemia, what is the primary cause of the macro-ovalocytes?
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What is the MOST likely reason for hypersegmented neutrophils seen in a patient with Megaloblastic anemia?
What is the MOST likely reason for hypersegmented neutrophils seen in a patient with Megaloblastic anemia?
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Which of these is a typical characteristic of Acute Leukemia that distinguishes it from Chronic Leukemia?
Which of these is a typical characteristic of Acute Leukemia that distinguishes it from Chronic Leukemia?
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In a patient suspected of having Acute Lymphoblastic Leukemia, what are the MOST prominent characteristics of the lymphoblasts?
In a patient suspected of having Acute Lymphoblastic Leukemia, what are the MOST prominent characteristics of the lymphoblasts?
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What is the MOST accurate statement regarding the Peroxidase test in the differentiation of Leukemia?
What is the MOST accurate statement regarding the Peroxidase test in the differentiation of Leukemia?
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Which of the following conditions is LEAST likely to present with splenomegaly?
Which of the following conditions is LEAST likely to present with splenomegaly?
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Which of the following is a CORRECT association between the specific type of antibody and the corresponding type of AIHA?
Which of the following is a CORRECT association between the specific type of antibody and the corresponding type of AIHA?
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Which of the following is a defining characteristic of Erythroid Maturation in both acute and chronic leukemia?
Which of the following is a defining characteristic of Erythroid Maturation in both acute and chronic leukemia?
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What statement CORRECTLY describes the relationship between antibody type and DAT findings in Warm AIHA?
What statement CORRECTLY describes the relationship between antibody type and DAT findings in Warm AIHA?
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Which of these BEST describes the role of the spleen in Warm AIHA?
Which of these BEST describes the role of the spleen in Warm AIHA?
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Which of these LABORATORY findings is MOST characteristic of a patient with severe Megaloblastic anemia?
Which of these LABORATORY findings is MOST characteristic of a patient with severe Megaloblastic anemia?
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Which of these is NOT a common clinical feature of Warm AIHA?
Which of these is NOT a common clinical feature of Warm AIHA?
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What is the MOST likely reason for the presence of basophilic stippling in red blood cells in Megaloblastic anemia?
What is the MOST likely reason for the presence of basophilic stippling in red blood cells in Megaloblastic anemia?
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Flashcards
Hemolytic Anemia
Hemolytic Anemia
A condition where red blood cells are destroyed faster than they can be made.
Heinz Bodies
Heinz Bodies
Aggregates of denatured hemoglobin found in red blood cells during hemolytic anemia.
Microangiopathic Hemolytic Anemia
Microangiopathic Hemolytic Anemia
A type of hemolytic anemia caused by small blood vessel damage.
Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic Thrombocytopenic Purpura (TTP)
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Disseminated Intravascular Coagulation (DIC)
Disseminated Intravascular Coagulation (DIC)
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Spherocytes
Spherocytes
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Acute Hemolytic Anemia
Acute Hemolytic Anemia
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Artificial Heart Valve
Artificial Heart Valve
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Schistocyte
Schistocyte
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Congenital Hemolytic Anemia
Congenital Hemolytic Anemia
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Warm AIHA
Warm AIHA
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Positive DAT
Positive DAT
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Cold AIHA
Cold AIHA
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Megaloblastic Anemia
Megaloblastic Anemia
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Macrocytic Anemia
Macrocytic Anemia
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Intrinsic Factor
Intrinsic Factor
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Reticulocytes
Reticulocytes
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Hypersegmented Neutrophils
Hypersegmented Neutrophils
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IDA
IDA
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Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia (AML)
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Lymphoblastic Leukemia
Lymphoblastic Leukemia
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Bone Marrow Hypercellularity
Bone Marrow Hypercellularity
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Anisocytosis
Anisocytosis
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Hypochromic Microcytic Anemia
Hypochromic Microcytic Anemia
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MCH
MCH
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MCV
MCV
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Serum Iron
Serum Iron
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Ferritin
Ferritin
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TIBC
TIBC
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Anemia of Chronic Disease
Anemia of Chronic Disease
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Sideroblastic Anemia
Sideroblastic Anemia
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Intrinsic Hemolytic Anemia
Intrinsic Hemolytic Anemia
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Sickle Cell Anemia
Sickle Cell Anemia
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Reticulocyte Count
Reticulocyte Count
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GGPD Deficiency
GGPD Deficiency
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Jaundice
Jaundice
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Splenomegaly
Splenomegaly
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Study Notes
Hypochromic Microcytic Anemia
- Key features:
- Mean corpuscular hemoglobin (MCH) is low (<32 g/dL)
- Mean corpuscular volume (MCV) is low (<80 fL)
Iron Deficiency Anemia
- Most common type of hypochromic microcytic anemia
- Symptoms: Fatigue, pallor, brittle nails, pica (craving non-food items like ice)
- Serum iron, ferritin, and transferrin receptor are affected
- Bone marrow iron stores are decreased
- Erythroblast iron is decreased
Anemia of Chronic Disorder
- Serum iron, ferritin and transferrin receptor are affected
- Bone Marrow iron stores are reduced/normal.
- Cause: chronic infection, inflammation, rheumatoid arthritis
Sideroblastic Anemia
- Serum iron and ferritin are elevated (iron overload)
- Transferrin is reduced
- % Transferrin saturation is elevated (body has too much iron)
- TIBC is normal
- Cause: genetic or acquired (alcoholism, pyridoxine deficiency, lead poisoning, isoniazid, chloramphenicol)
Thalassemia, Abnormal Hemoglobin
- Often have normal or slightly elevated serum iron and ferritin
- Low MCH, MCV
- Haemoglobin studies (HbF/HbA2) are abnormal
Thalassemia Minor
- Ferritin, Serum iron and transferrin are normal or elevated.
- TIBC normal
- Transferrin saturation slightly abnormal
Hemolytic Anemia
- Increased reticulocytes
- Intrinsic causes: defects in red blood cell membranes, enzymes
- Extrinsic causes: immune mechanisms, mechanical damage, infections
Non-Hemolytic Normochromic Normocytic Anemia
- Normal MCV (80-100 fL)
- Non-hemoglobinopathy anemias
- Causes: Iron deficiency, chronic disease, chronic kidney disease, aplastic anemia
Intrinsic Haemolytic Anemia
- Clinical Features: fluctuating jaundice, splenomegaly, pigment gallstones
- Cause: hereditary spherocytosis, hereditary elliptocytosis, G6PD deficiency
Microangiopathic Haemolytic Anemia (MAHA)
- Fragmented red blood cells (schistocytes, helmet cells)
- Cause: Disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), artificial heart valve
Autoimmune Haemolytic Anemia (AIHA)
- Warm AIHA: Splenomegaly, spherocytes increase MCHC.
- Cold AIHA: Skin manifestations, acrocyanosis
Megaloblastic Anemia
- MCV > 100 fL
- Insufficient nuclear DNA Synthesis (lack of vitamin B12/folate)
- Large RBC due to continued hemoglobin production.
- Oval morphology (macro-ovalocytes)
- Symptoms: Fatigue, headache, palpitations, dyspnea, gray hair
- Lab findings: increased LDH, indirect bilirubin, haptoglobin
- Causes: Lack of intrinsic factor, destruction of gastric parietal cells, anti-gastric parietal cell auto antibodies
Blast Cells
- Erythroid maturation: Proerythroblast, Basophilic erythroblast, polychromatophilic erythroblast, orthochromatic erythroblast, reticulocytes, erythrocyte
- Granulocytic maturation: Myeloblast, promyelocyte, myelocyte, metamyelocyte, neutrophil, band neutrophil
- Lymphocytic Leukemia/Lymphoma: Lymphoblasts, (small, condensed nuclear chromatin, small nucleoli, scant agranular cytoplasm)
- Acute myeloid leukaemia (AML): Myeloblasts, (delicate nuclear chromatin, prominent nucleoli, fine azurophilic cytoplasmic granules)
Leukemia
- Acute vs chronic: differing onset and dominance of cell types
- Myeloid vs lymphoid: affecting different hematopoietic cell lineages
- Acute myeloid leukemia (AML): immature myeloid blasts
- Chronic myeloid leukemia (CML): mature myeloid cells
- Acute lymphoblastic leukemia (ALL): immature lymphoid blasts
- Chronic lymphocytic leukemia (CLL): mature lymphoid cells
- Diagnostics include blood smears, bone marrow biopsies and immunologic tests
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Description
This quiz explores various types of anemia, including hypochromic microcytic anemia, iron deficiency anemia, anemia of chronic disorder, and sideroblastic anemia. Understand key features, symptoms, and underlying causes of each type to enhance your knowledge in hematology.