10 Questions
In which mode are dialyzers typically operated today?
Countercurrent flow mode
What is the impact of cocurrent flow mode on the clearance of smaller molecules?
Decreases clearance by 10%
What is the Sieving coefficient for larger molecules in exemplary dialyzers?
10%
What does the sieving coefficient (S) represent?
The ratio of concentration in filtrate to concentration in plasma
What is the fractional excretion (FE) defined as?
The percentage of a substance's matter flow in the final urine compared to the matter flow in the primary urine
What does renal blood flow (RBF) represent?
Blood flow through the kidneys
What is the primary function of the cells in the proximal tubule in relation to the acid-base balance?
Reabsorbing bicarbonate (HCO3-) and excreting H+ protons
How does the kidney regulate the balance in case of alkalosis?
By decreasing the reabsorption of bicarbonate and increasing the excretion of bicarbonate
What is the role of the lungs in regulating the acid-base balance?
Excreting CO2 generated by cells
What is the primary function of renal blood flow (RBF) in relation to kidney parameters?
Maintaining glomerular filtration rate (GFR)
Study Notes
Dialyzer Operation
- Dialyzers are typically operated in countercurrent flow mode today.
Clearance of Small Molecules
- Cocurrent flow mode decreases the clearance of smaller molecules.
Sieving Coefficient
- The sieving coefficient (S) represents the ability of a dialyzer to remove molecules of a specific size.
- For larger molecules, the sieving coefficient (S) is typically lower in exemplary dialyzers.
Renal Function
- Renal blood flow (RBF) represents the amount of blood that flows through the kidneys.
- Primary function of RBF is to regulate kidney parameters such as filtration rate and waste removal.
Acid-Base Balance
- Cells in the proximal tubule play a crucial role in maintaining acid-base balance by reabsorbing bicarbonate and eliminating hydrogen ions.
- In cases of alkalosis, the kidney regulates the balance by increasing hydrogen ion excretion and decreasing bicarbonate reabsorption.
Respiratory Regulation
- Lungs play a vital role in regulating the acid-base balance by removing carbon dioxide through exhalation, which helps to reduce hydrogen ion concentration in the blood.
Test your knowledge of the regulatory effect on the acid-base balance, focusing on the role of the lungs and kidneys in managing CO2 and bicarbonate levels. Understand the processes of CO2 generation, excretion by the lungs, and H+ excretion and HCO3- reabsorption by the kidneys.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
