Anatomy and Physiology: Renal System Specializations
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Questions and Answers

What is the main function of the Bowman’s capsule in the kidney?

  • Filtration of blood (correct)
  • Production of renin
  • Control of urine concentration
  • Reabsorption of electrolytes

In which part of the nephron is the majority of the filtrate bulk reabsorbed?

  • Distal tubule
  • Collecting duct
  • Loop of Henle
  • Proximal tubule (correct)

Which animal species has a kidney structure characterized by being multipapillate with no fusion between cortex and medulla?

  • Sheep (correct)
  • Horse
  • Cat
  • Dog

What is the role of the Juxta-glomerular apparatus in kidney function?

<p>Production of renin (D)</p> Signup and view all the answers

Which part of the kidney is responsible for setting up high osmolarity in the medulla?

<p>Loop of Henle (C)</p> Signup and view all the answers

What is the main driving force for filtration at the level of the glomerulus?

<p>Hydrostatic pressure of the blood in the glomerular capillary (B)</p> Signup and view all the answers

What is the function of the renal clearance measurement?

<p>To quantify the rate of waste product removal from the blood by the kidneys (D)</p> Signup and view all the answers

How is Glomerular Filtration Rate (GFR) defined?

<p>As a measure of kidney function (B)</p> Signup and view all the answers

What is Starling's Principle primarily concerned with in relation to glomerular filtration?

<p>Calculating net filtration pressure (C)</p> Signup and view all the answers

How is Filtration Fraction (FF) calculated?

<p>(GFR / RPF) (B)</p> Signup and view all the answers

How do changes in pressure within the afferent and efferent arterioles impact the glomerular filtration rate (GFR)?

<p>Afferent arteriolar vasoconstriction increases GFR, while efferent arteriolar vasodilation decreases GFR. (D)</p> Signup and view all the answers

What is the impact of vasodilation in the afferent arteriole and vasoconstriction in the efferent arteriole on glomerular filtration?

<p>Decreases GFR due to increased hydrostatic pressure but decreased blood flow in the glomerulus. (C)</p> Signup and view all the answers

How is renal blood flow regulated in terms of autoregulation mechanisms?

<p>Renal blood flow and GFR remain constant irrespective of blood pressure changes due to autoregulation mechanisms. (A)</p> Signup and view all the answers

What role does the autonomic nervous system play in regulating renal blood flow?

<p>It can increase or decrease renal blood flow by constricting or dilating renal arterioles. (D)</p> Signup and view all the answers

Which mechanism involves the movement of solutes across a membrane against a concentration gradient?

<p>Active transport (C)</p> Signup and view all the answers

What is the function of the Loop of Henle in establishing a concentration gradient?

<p>Maintaining medullary hypertonicity through countercurrent exchange (C)</p> Signup and view all the answers

Which segment of the nephron is impermeable to water and actively pumps out solutes like sodium and chloride?

<p>Thick ascending loop of Henle (TAL) (D)</p> Signup and view all the answers

How does the Vasa Recta contribute to maintaining concentration gradient in the medulla?

<p>Losing solutes as blood descends (A)</p> Signup and view all the answers

What role does the collecting duct play in the nephron?

<p>Facilitating urine transport to the ureters (C)</p> Signup and view all the answers

How does sodium reabsorption occur in the thick ascending limb of Loop of Henle?

<p>Through the NKCC2 transporter on the apical membrane (D)</p> Signup and view all the answers

What hormone is responsible for increasing red blood cell production in response to kidney damage?

<p>Erythropoietin (B)</p> Signup and view all the answers

How does chronic renal failure lead to secondary hyperparathyroidism according to the text?

<p>Decrease in Nephrons (D)</p> Signup and view all the answers

Which hormone is responsible for stimulating thirst when there is a decrease in fluid volume or an increase in blood osmolarity?

<p>Anti-diuretic hormone (ADH) (C)</p> Signup and view all the answers

What mechanism allows the kidney to conserve water by making more concentrated urine?

<p>Osmotic gradient in the medulla (B)</p> Signup and view all the answers

How does ADH act in the kidney to increase water reabsorption?

<p>Insertion of aquaporin channels in the apical membrane (D)</p> Signup and view all the answers

What is the primary role of antidiuretic hormone (ADH) in the kidney?

<p>Regulating the water permeability of the collecting duct (C)</p> Signup and view all the answers

How does aldosterone affect the collecting duct in the kidney?

<p>It modulates ion transport such as Na+ and K+ in the collecting duct (A)</p> Signup and view all the answers

What initiates the renin-angiotensin-aldosterone system (RAAS)?

<p>Decrease in renal blood pressure detected by baroreceptors (D)</p> Signup and view all the answers

How does an increase in osmolarity trigger the release of antidiuretic hormone (ADH)?

<p>By activating osmoreceptors in the hypothalamus (D)</p> Signup and view all the answers

What is a direct effect of angiotensin II in the renin-angiotensin-aldosterone system (RAAS)?

<p>Causes vasoconstriction of small arteries (arterioles) (B)</p> Signup and view all the answers

What is the primary metabolite derived from dietary protein and tissue protein turnover?

<p>Urea (B)</p> Signup and view all the answers

Which hormone promotes sodium and water retention, leading to an increase in blood volume and blood pressure?

<p>Aldosterone (A)</p> Signup and view all the answers

What occurs when there is a decrease in blood flow to the kidneys or blood pressure?

<p>Release of renin (B)</p> Signup and view all the answers

What is the enzyme that converts angiotensin I to angiotensin II?

<p>ACE (Angiotensin-Converting Enzyme) (A)</p> Signup and view all the answers

Which neurotransmitter stimulates the heart to increase heart rate and contractility?

<p>Norepinephrine (B)</p> Signup and view all the answers

Why does chronic kidney disease commonly lead to hypertension in dogs and cats?

<p>Due to the kidneys receiving a large percentage of blood, leading to blood backing up into arteries and increasing blood pressure. (C)</p> Signup and view all the answers

What is the normal range for urine specific gravity in cats consuming a drier diet?

<p>1.001 - 1.080 (B)</p> Signup and view all the answers

What is the main difference between hyposthenuria and hypersthenuria?

<p>Hyposthenuria is a condition with neither concentrated nor dilute urine, while hypersthenuria is a condition with concentrated urine. (B)</p> Signup and view all the answers

What is the difference between azotaemia and uraemia?

<p>Azotaemia starts as a precursor to kidney failure, while uraemia indicates advanced kidney dysfunction with complications. (A)</p> Signup and view all the answers

What is the function of the IRIS scale in feline kidney disease?

<p>It classifies stages of kidney disease based on severity and provides treatment guidelines. (A)</p> Signup and view all the answers

Chronic kidney disease is a common cause of hypertension in ______ and cats

<p>dogs</p> Signup and view all the answers

Feline hypertension is commonly associated with chronic renal failure in ______ and cats

<p>dogs</p> Signup and view all the answers

Urine specific gravity measures the ratio of the urine density compared with ______ density

<p>water</p> Signup and view all the answers

Dogs have a normal urine specific gravity range of 1.001 - 1.060 with an average of ______

<p>1.025</p> Signup and view all the answers

Cats consuming dry foods have a urine specific gravity range of > 1.035, while cats consuming wet foods have a range of > ______

<p>1.025</p> Signup and view all the answers

Hyposthenuria is characterized by abnormally low urinary specific gravity and osmolarity, leading to ______ urine formation

<p>dilute</p> Signup and view all the answers

Isothenuria is a condition where urine is neither more nor less concentrated than the plasma and glomerular filtrate, resulting in urine that is not ______ or dilute

<p>concentrated</p> Signup and view all the answers

Uraemia specifically refers to the symptomatic and advanced stage of kidney failure characterized by elevated nitrogenous waste products along with associated ______

<p>symptoms</p> Signup and view all the answers

Azotemia indicates impaired kidney function and is often a precursor to ______

<p>uraemia</p> Signup and view all the answers

The IRIS scale plays a role in feline kidney disease and has four main ______

<p>classifications</p> Signup and view all the answers

Define hyposthenuria.

<p>Hyposthenuria is an abnormally low urinary specific gravity and osmolarity, leading to dilute urine formation.</p> Signup and view all the answers

Explain the difference between azotaemia and uraemia.

<p>Azotemia refers to increased blood concentrations of nitrogenous waste products, indicating kidney dysfunction without symptoms. Uraemia describes the symptomatic stage with high levels of waste products leading to complications.</p> Signup and view all the answers

What is the role of the IRIS scale in feline kidney disease?

<p>The IRIS scale categorizes the severity of chronic kidney disease in cats into four stages based on blood creatinine levels.</p> Signup and view all the answers

Define isosthenuria.

<p>Isosthenuria is a condition where urine is neither more nor less concentrated than the plasma and glomerular filtrate, resulting in urine that is not concentrated or dilute.</p> Signup and view all the answers

What is hypersthenuria?

<p>Hypersthenuria is urine with a high osmolarity and high urinary specific gravity compared to the plasma and glomerular filtrate, leading to concentrated urine.</p> Signup and view all the answers

State the target organs that can be damaged by hypertension.

<p>Hypertension can damage organs such as the heart, kidneys, brain, and eyes.</p> Signup and view all the answers

Identify breeds of cat at risk of inherited causes of chronic kidney disease.

<p>Breeds like Persians, Abyssinians, Siamese, and Russian Blues are at increased risk of inherited chronic kidney disease.</p> Signup and view all the answers

What is the significance of urine specific gravity in cats and dogs?

<p>Urine specific gravity indicates the kidney's ability to concentrate urine, providing insights into kidney function.</p> Signup and view all the answers

Explain the role of the Juxta-glomerular apparatus in kidney function.

<p>The Juxta-glomerular apparatus regulates blood pressure and filtration rate by secreting renin in response to changes in blood flow and pressure.</p> Signup and view all the answers

How does chronic renal failure lead to secondary hyperparathyroidism?

<p>Chronic renal failure causes decreased calcium excretion, leading to increased phosphate levels, stimulating parathyroid hormone release and resulting in secondary hyperparathyroidism.</p> Signup and view all the answers

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