34 Spleen ANATOMY AND PHYSIOLOGY
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34 Spleen ANATOMY AND PHYSIOLOGY

Test your knowledge on the anatomy and functions of the spleen with this quiz. Topics include the blood supply, ligaments, and roles in immune function and blood filtration.

Created by
@ExcitedChalcedony7132

Questions and Answers

Which artery supplies blood to the spleen?

Splenic artery

What is the function of the white pulp in the spleen?

Immunologic function

Which antibody is the largest producer in the spleen?

IgM

What is the role of the short gastrics and splenic artery in the spleen?

<p>Contain short gastric arteries</p> Signup and view all the answers

In the spleen, what occurs with the interaction between dendritic cells/macrophages and helper T cells?

<p>Antigen processing</p> Signup and view all the answers

What is the main function of the red pulp in the spleen?

<p>Filtering of aged/damaged RBCs</p> Signup and view all the answers

Which organ serves as a reservoir for platelets?

<p>Spleen</p> Signup and view all the answers

What is the most common congenital lack of ligaments holding the spleen in place?

<p>Wandering spleen</p> Signup and view all the answers

What is the primary treatment for idiopathic thrombocytopenic purpura (ITP)?

<p>Steroids</p> Signup and view all the answers

What is the cause of thrombotic thrombocytopenic purpura (TTP)?

<p>ADAMTS13 defect</p> Signup and view all the answers

Which condition is associated with a 0.1% risk of developing post-splenectomy sepsis syndrome (PSSS)?

<p>Hodgkin's disease</p> Signup and view all the answers

What is the treatment for warm antibody-type acquired immune hemolytic anemia?

<p>Splenectomy</p> Signup and view all the answers

What is the most common thalassemia, characterized by persistent HgbF?

<p>Beta-thalassemia</p> Signup and view all the answers

What type of cells are seen in Hodgkin's disease?

<p>Reed-Sternberg cells</p> Signup and view all the answers

'Spherocytosis' leads to less deformable RBCs and splenic culling/sequestration due to a deficit of which membrane protein?

<p>'A' band 3 protein</p> Signup and view all the answers

Which type of non-Hodgkin's lymphoma is generally associated with the worst prognosis?

<p>Lymphocyte depleted</p> Signup and view all the answers

What is the most common type of non-Hodgkin's lymphoma?

<p>Nodular sclerosing</p> Signup and view all the answers

What is the most common malignant splenic tumor?

<p>Angiosarcoma</p> Signup and view all the answers

Which condition is associated with Felty's syndrome?

<p>Sarcoidosis of spleen</p> Signup and view all the answers

What is the most common cause of chylous ascites?

<p>Non-Hodgkin's lymphoma</p> Signup and view all the answers

What is the recommended workup for lymphoma?

<p>Bone marrow biopsy and gallium MRI or PET scan of the liver and spleen</p> Signup and view all the answers

In which condition are Howell–Jolly bodies often seen?

<p>Hyposplenism</p> Signup and view all the answers

Which condition rarely requires splenectomy?

<p>Splenosis</p> Signup and view all the answers

Which condition manifests as anemia and decreased platelets due to splenomegaly?

<p>Sarcoidosis of spleen</p> Signup and view all the answers

Which is the #1 benign splenic tumor?

<p>Hemangioma</p> Signup and view all the answers

What is the most common cause of splenic artery or splenic vein thrombosis?

<p>Pancreatitis</p> Signup and view all the answers

What condition can lead to a low attenuation fluid collection in the lesser sac/postsplenectomy space?

<p>Echinococcal splenic cyst</p> Signup and view all the answers

Study Notes

  • The spleen receives blood supply from the splenic artery.
  • The white pulp in the spleen functions as a lymphoid tissue, producing immune cells.
  • IgM is the largest producer of antibodies in the spleen.
  • The short gastrics and splenic artery supply the spleen with oxygenated blood.

Immune Function in the Spleen

  • Dendritic cells/macrophages interact with helper T cells in the spleen, facilitating immune responses.

Red Pulp Function

  • The red pulp in the spleen filters the blood, removing old or damaged red blood cells and recycling iron.

Platelet Reservoir

  • The spleen serves as a reservoir for platelets.

Congenital Conditions

  • The most common congenital lack of ligaments holding the spleen in place is wandering spleen.

Idiopathic Thrombocytopenic Purpura (ITP)

  • The primary treatment for ITP is corticosteroids.

Thrombotic Thrombocytopenic Purpura (TTP)

  • TTP is caused by a deficiency of ADAMTS13, a metalloprotease.

Post-Splenectomy Sepsis Syndrome (PSSS)

  • Hereditary spherocytosis is associated with a 0.1% risk of developing PSSS.

Acquired Immune Hemolytic Anemia

  • The treatment for warm antibody-type acquired immune hemolytic anemia is corticosteroids and rituximab.

Thalassemia

  • The most common thalassemia is HbF-Bart's, characterized by persistent HgbF.

Hodgkin's Disease

  • Lymphocyte-predominant cells are seen in Hodgkin's disease.

Hereditary Spherocytosis

  • A deficit of spectrin, a membrane protein, leads to less deformable RBCs and splenic culling/sequestration.

Non-Hodgkin's Lymphoma

  • Mantle cell lymphoma is generally associated with the worst prognosis.
  • Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma.

Malignant Spleen Tumors

  • Lymphoma is the most common malignant splenic tumor.

Felty's Syndrome

  • Felty's syndrome is associated with rheumatoid arthritis, splenomegaly, and neutropenia.

Chylous Ascites

  • The most common cause of chylous ascites is trauma.

Lymphoma Workup

  • The recommended workup for lymphoma includes CT scans, PET scans, and bone marrow biopsies.

Howell-Jolly Bodies

  • Howell-Jolly bodies are often seen in hereditary spherocytosis.

Splenectomy

  • Hereditary spherocytosis rarely requires splenectomy.

Hemolytic Anemia

  • Hemolytic anemia and decreased platelets can occur due to splenomegaly.

Benign Spleen Tumors

  • Hemangioma is the most common benign splenic tumor.

Splenic Artery or Vein Thrombosis

  • The most common cause of splenic artery or splenic vein thrombosis is pancreatitis.

Low Attenuation Fluid Collection

  • A low attenuation fluid collection in the lesser sac/postsplenectomy space can occur due to a pseudocyst.

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