Podcast
Questions and Answers
Which artery supplies blood to the spleen?
Which artery supplies blood to the spleen?
- Inferior mesenteric artery
- Superior mesenteric artery
- Left gastric artery
- Splenic artery (correct)
What is the function of the white pulp in the spleen?
What is the function of the white pulp in the spleen?
- Site of bacterial clearance
- Immunologic function (correct)
- Filtering of aged/damaged RBCs
- Antigen processing
Which antibody is the largest producer in the spleen?
Which antibody is the largest producer in the spleen?
- IgA
- IgG
- IgM (correct)
- IgE
What is the role of the short gastrics and splenic artery in the spleen?
What is the role of the short gastrics and splenic artery in the spleen?
In the spleen, what occurs with the interaction between dendritic cells/macrophages and helper T cells?
In the spleen, what occurs with the interaction between dendritic cells/macrophages and helper T cells?
What is the main function of the red pulp in the spleen?
What is the main function of the red pulp in the spleen?
Which organ serves as a reservoir for platelets?
Which organ serves as a reservoir for platelets?
What is the most common congenital lack of ligaments holding the spleen in place?
What is the most common congenital lack of ligaments holding the spleen in place?
What is the primary treatment for idiopathic thrombocytopenic purpura (ITP)?
What is the primary treatment for idiopathic thrombocytopenic purpura (ITP)?
What is the cause of thrombotic thrombocytopenic purpura (TTP)?
What is the cause of thrombotic thrombocytopenic purpura (TTP)?
Which condition is associated with a 0.1% risk of developing post-splenectomy sepsis syndrome (PSSS)?
Which condition is associated with a 0.1% risk of developing post-splenectomy sepsis syndrome (PSSS)?
What is the treatment for warm antibody-type acquired immune hemolytic anemia?
What is the treatment for warm antibody-type acquired immune hemolytic anemia?
What is the most common thalassemia, characterized by persistent HgbF?
What is the most common thalassemia, characterized by persistent HgbF?
What type of cells are seen in Hodgkin's disease?
What type of cells are seen in Hodgkin's disease?
'Spherocytosis' leads to less deformable RBCs and splenic culling/sequestration due to a deficit of which membrane protein?
'Spherocytosis' leads to less deformable RBCs and splenic culling/sequestration due to a deficit of which membrane protein?
Which type of non-Hodgkin's lymphoma is generally associated with the worst prognosis?
Which type of non-Hodgkin's lymphoma is generally associated with the worst prognosis?
What is the most common type of non-Hodgkin's lymphoma?
What is the most common type of non-Hodgkin's lymphoma?
What is the most common malignant splenic tumor?
What is the most common malignant splenic tumor?
Which condition is associated with Felty's syndrome?
Which condition is associated with Felty's syndrome?
What is the most common cause of chylous ascites?
What is the most common cause of chylous ascites?
What is the recommended workup for lymphoma?
What is the recommended workup for lymphoma?
In which condition are Howell–Jolly bodies often seen?
In which condition are Howell–Jolly bodies often seen?
Which condition rarely requires splenectomy?
Which condition rarely requires splenectomy?
Which condition manifests as anemia and decreased platelets due to splenomegaly?
Which condition manifests as anemia and decreased platelets due to splenomegaly?
Which is the #1 benign splenic tumor?
Which is the #1 benign splenic tumor?
What is the most common cause of splenic artery or splenic vein thrombosis?
What is the most common cause of splenic artery or splenic vein thrombosis?
What condition can lead to a low attenuation fluid collection in the lesser sac/postsplenectomy space?
What condition can lead to a low attenuation fluid collection in the lesser sac/postsplenectomy space?
Flashcards
Splenic Artery
Splenic Artery
The artery that supplies blood to the spleen.
White Pulp
White Pulp
Lymphoid tissue in the spleen responsible for immune cell production, primarily IgM.
Red Pulp
Red Pulp
The part of the spleen that filters the blood, removing old or damaged red blood cells and recycling iron.
Platelet Reservoir
Platelet Reservoir
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Wandering Spleen
Wandering Spleen
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ITP
ITP
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TTP
TTP
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PSSS
PSSS
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Acquired Immune Hemolytic Anemia
Acquired Immune Hemolytic Anemia
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Thalassemia
Thalassemia
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Hodgkin's Disease
Hodgkin's Disease
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Hereditary Spherocytosis
Hereditary Spherocytosis
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Mantle Cell Lymphoma
Mantle Cell Lymphoma
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Diffuse Large B-cell Lymphoma
Diffuse Large B-cell Lymphoma
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Felty's Syndrome
Felty's Syndrome
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Chylous Ascites
Chylous Ascites
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Howell-Jolly Bodies
Howell-Jolly Bodies
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Hemolytic Anemia
Hemolytic Anemia
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Hemangioma
Hemangioma
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Splenic Artery or Vein Thrombosis
Splenic Artery or Vein Thrombosis
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Low Attenuation Fluid Collection
Low Attenuation Fluid Collection
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Dendritic Cells and Macrophages
Dendritic Cells and Macrophages
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Lymphoma
Lymphoma
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Corticosteroids
Corticosteroids
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CT Scan, PET Scan, Bone Marrow Biopsy
CT Scan, PET Scan, Bone Marrow Biopsy
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Pseudocyst
Pseudocyst
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Splenectomy
Splenectomy
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Splenomegaly
Splenomegaly
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Study Notes
Spleen and Related Conditions
- The spleen receives blood supply from the splenic artery.
- The white pulp in the spleen functions as a lymphoid tissue, producing immune cells.
- IgM is the largest producer of antibodies in the spleen.
- The short gastrics and splenic artery supply the spleen with oxygenated blood.
Immune Function in the Spleen
- Dendritic cells/macrophages interact with helper T cells in the spleen, facilitating immune responses.
Red Pulp Function
- The red pulp in the spleen filters the blood, removing old or damaged red blood cells and recycling iron.
Platelet Reservoir
- The spleen serves as a reservoir for platelets.
Congenital Conditions
- The most common congenital lack of ligaments holding the spleen in place is wandering spleen.
Idiopathic Thrombocytopenic Purpura (ITP)
- The primary treatment for ITP is corticosteroids.
Thrombotic Thrombocytopenic Purpura (TTP)
- TTP is caused by a deficiency of ADAMTS13, a metalloprotease.
Post-Splenectomy Sepsis Syndrome (PSSS)
- Hereditary spherocytosis is associated with a 0.1% risk of developing PSSS.
Acquired Immune Hemolytic Anemia
- The treatment for warm antibody-type acquired immune hemolytic anemia is corticosteroids and rituximab.
Thalassemia
- The most common thalassemia is HbF-Bart's, characterized by persistent HgbF.
Hodgkin's Disease
- Lymphocyte-predominant cells are seen in Hodgkin's disease.
Hereditary Spherocytosis
- A deficit of spectrin, a membrane protein, leads to less deformable RBCs and splenic culling/sequestration.
Non-Hodgkin's Lymphoma
- Mantle cell lymphoma is generally associated with the worst prognosis.
- Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma.
Malignant Spleen Tumors
- Lymphoma is the most common malignant splenic tumor.
Felty's Syndrome
- Felty's syndrome is associated with rheumatoid arthritis, splenomegaly, and neutropenia.
Chylous Ascites
- The most common cause of chylous ascites is trauma.
Lymphoma Workup
- The recommended workup for lymphoma includes CT scans, PET scans, and bone marrow biopsies.
Howell-Jolly Bodies
- Howell-Jolly bodies are often seen in hereditary spherocytosis.
Splenectomy
- Hereditary spherocytosis rarely requires splenectomy.
Hemolytic Anemia
- Hemolytic anemia and decreased platelets can occur due to splenomegaly.
Benign Spleen Tumors
- Hemangioma is the most common benign splenic tumor.
Splenic Artery or Vein Thrombosis
- The most common cause of splenic artery or splenic vein thrombosis is pancreatitis.
Low Attenuation Fluid Collection
- A low attenuation fluid collection in the lesser sac/postsplenectomy space can occur due to a pseudocyst.
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Description
Test your knowledge on the anatomy and functions of the spleen with this quiz. Topics include the blood supply, ligaments, and roles in immune function and blood filtration.
