Analgesics Overview and Usage

Antipyretic, analgesic, antiplatelet drug. 81mg daily for cardiac issues, 325mg for acute MI. Enteric-coated to prevent stomach irritation.

Antipyretic and analgesic that blocks pain receptors, lacks anti-inflammatory properties. Liver damage risk with long-term use (especially with alcohol).

Less than 3000mg in 24 hours.

N-acetylcysteine (NAC/Mucomyst) administered orally or intravenously.

Antipyretic and anti-inflammatory drugs affecting steroidal function. Can increase bleeding time.

Monitor kidney function with long-term NSAID use due to potential for kidney problems.

High risk of severe allergic reactions (anaphylaxis).

Less than 3600mg per 24 hours.

IV NSAID, 15-30mg Q6; maximum of 120mg/day (30mg) or 60mg (15mg).

Affect opioid receptors in the brain. Slows HR, BP, RR, and causes GI effects like constipation.

Caution with hypovolemic or unstable patients, and check for allergies to ASA and APAP.

Heparin-Protamine Sulfate, Vitamin K

Lower blood pressure by inhibiting angiotensin and decreasing aldosterone, leading to sodium and water excretion.

Possible potassium retention, dry cough, metallic taste, dizziness, fatigue, and headache.

Combining ACE inhibitors with NSAIDs can reduce the effectiveness of ACE inhibitors.

Block beta-adrenergic receptors to slow heart rate and lower blood pressure by decreasing cardiac output and oxygen consumption.

Dilate arteries by preventing calcium from entering cells, reducing blood pressure and workload on the heart.

Regularly monitor blood pressure, heart rate, and electrolytes (especially potassium) when taking cardiac medications.

81mg daily for cardiac issues, 325mg for acute MI, antiplatelet, antipyretic, analgesic, enteric-coated to prevent stomach issues

Maximum dose: less than 3000mg/24 hrs

Liver damage with long-term use, especially with alcohol

N-acetylcysteine (NAC/Mucomyst), oral or IV

Anti-inflammatory, antipyretic, affect steroidal function. Monitor kidney function, high risk of anaphylaxis

Less than 3600 mg/24 hrs

15-30mg Q6hrs; IV, max 120mg/day (30mg dose) or 60mg/day (15mg dose)

Affect brain opioid receptors, slow HR, BP, RR, cause constipation, altered mental state

Avoid hypovolemic, unstable patients, and check for ASA/APAP allergy; monitor RR before administering

Treats blood clots or decreasing MI

Used to treat blood clots or prevent, or decrease MI (heart attack)

Rotate injection sites in abdomen, and keep seal on air bubble

Increased risk with ETOH abuse, liver failure, and certain medications

Limit green leafy vegetables to avoid decreasing vitamin k levels.