Analgesics and Pain Management

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RenownedCypress
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What is the primary purpose of opioid analgesics?

Relieve acute pain

Which neurotransmitters do endogenous opioids act on in the central nervous system (CNS)?

Endorphins & enkephalins

How do opioid analgesics produce their analgesic effects?

By impeding neuronal firing and transmitter release

Which opioid analgesic is primarily an agonist on the Mu receptor present in the central nervous system (CNS), gastrointestinal tract (GIT), and peripheral tissues?

<p>Codeine</p> Signup and view all the answers

What is the main effect of morphine on the body?

<p>Relief of pain without loss of consciousness</p> Signup and view all the answers

What is the primary mechanism of action for NSAIDs?

<p>Inhibition of cyclooxygenase (COX) enzymes, leading to decreased prostaglandin synthesis</p> Signup and view all the answers

Which enzyme is inhibited by NSAIDs to reduce the synthesis of prostaglandins that cause pain and inflammation?

<p>Cyclooxygenase (COX)</p> Signup and view all the answers

Which enzyme is responsible for the synthesis of housekeeping prostaglandins that protect the gastric mucosa and maintain normal kidney function?

<p>Cyclooxygenase (COX)-1</p> Signup and view all the answers

What is the primary difference between COX-1 and COX-2 enzymes?

<p>COX-1 synthesizes prostaglandins causing pain and inflammation, while COX-2 synthesizes housekeeping prostaglandins</p> Signup and view all the answers

Which of the following are common side effects associated with NSAIDs?

<p>Gastric ulcer and renal failure</p> Signup and view all the answers

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