Analgesics and Pain Management
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Questions and Answers

What is the primary purpose of opioid analgesics?

  • Relieve mild to moderate pain
  • Relieve acute pain (correct)
  • Reduce inflammation
  • Relieve chronic pain

Which neurotransmitters do endogenous opioids act on in the central nervous system (CNS)?

  • Serotonin
  • Dopamine
  • Acetylcholine
  • Endorphins & enkephalins (correct)

How do opioid analgesics produce their analgesic effects?

  • By acting on GABA receptors
  • By impeding neuronal firing and transmitter release (correct)
  • By increasing presynaptic calcium influx
  • By reducing postsynaptic potassium efflux

Which opioid analgesic is primarily an agonist on the Mu receptor present in the central nervous system (CNS), gastrointestinal tract (GIT), and peripheral tissues?

<p>Codeine (B)</p> Signup and view all the answers

What is the main effect of morphine on the body?

<p>Relief of pain without loss of consciousness (D)</p> Signup and view all the answers

What is the primary mechanism of action for NSAIDs?

<p>Inhibition of cyclooxygenase (COX) enzymes, leading to decreased prostaglandin synthesis (B)</p> Signup and view all the answers

Which enzyme is inhibited by NSAIDs to reduce the synthesis of prostaglandins that cause pain and inflammation?

<p>Cyclooxygenase (COX) (A)</p> Signup and view all the answers

Which enzyme is responsible for the synthesis of housekeeping prostaglandins that protect the gastric mucosa and maintain normal kidney function?

<p>Cyclooxygenase (COX)-1 (B)</p> Signup and view all the answers

What is the primary difference between COX-1 and COX-2 enzymes?

<p>COX-1 synthesizes prostaglandins causing pain and inflammation, while COX-2 synthesizes housekeeping prostaglandins (C)</p> Signup and view all the answers

Which of the following are common side effects associated with NSAIDs?

<p>Gastric ulcer and renal failure (C)</p> Signup and view all the answers

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