Podcast
Questions and Answers
Which route of administration is preferred for hospitalised patients?
Which route of administration is preferred for hospitalised patients?
Which opioid is known to cause significant histamine release when administered intravenously?
Which opioid is known to cause significant histamine release when administered intravenously?
Which opioid is considered to have a lower risk of hypoventilation compared to methadone?
Which opioid is considered to have a lower risk of hypoventilation compared to methadone?
Which type of analgesic is approved for chronic use in dogs?
Which type of analgesic is approved for chronic use in dogs?
Signup and view all the answers
Which drug is known to have an abuse potential when administered via a patch?
Which drug is known to have an abuse potential when administered via a patch?
Signup and view all the answers
Which opioid is highly potent and suitable for remote administration devices?
Which opioid is highly potent and suitable for remote administration devices?
Signup and view all the answers
Which NSAID tablet lasts for 2-4 weeks?
Which NSAID tablet lasts for 2-4 weeks?
Signup and view all the answers
Which opioid is known to have a rapid onset of action and short duration when administered intravenously?
Which opioid is known to have a rapid onset of action and short duration when administered intravenously?
Signup and view all the answers
Which opioid is highly potent and has a long duration of action when administered via a patch?
Which opioid is highly potent and has a long duration of action when administered via a patch?
Signup and view all the answers
Which type of drug is known to have a lower injection volume due to its potency?
Which type of drug is known to have a lower injection volume due to its potency?
Signup and view all the answers
Which class of drugs can be utilized for pain relief, sedation, reducing the required dose of general anesthetic, treating diarrhea, and controlling coughing?
Which class of drugs can be utilized for pain relief, sedation, reducing the required dose of general anesthetic, treating diarrhea, and controlling coughing?
Signup and view all the answers
What is the mechanism of action of NSAIDs?
What is the mechanism of action of NSAIDs?
Signup and view all the answers
What are the contraindications for opioid analgesics?
What are the contraindications for opioid analgesics?
Signup and view all the answers
What is the new development in analgesia acting as an antagonist of prostaglandin E2 at EP4 receptors while sparing the production of 'physiological' prostaglandins, leading to fewer adverse effects?
What is the new development in analgesia acting as an antagonist of prostaglandin E2 at EP4 receptors while sparing the production of 'physiological' prostaglandins, leading to fewer adverse effects?
Signup and view all the answers
What do local anesthetics block to provide analgesia and antidysrhythmic action?
What do local anesthetics block to provide analgesia and antidysrhythmic action?
Signup and view all the answers
Which class of drugs can lead to side effects such as dyspepsia, GIT ulceration, renal toxicity, and hepatic toxicity?
Which class of drugs can lead to side effects such as dyspepsia, GIT ulceration, renal toxicity, and hepatic toxicity?
Signup and view all the answers
What is the main effect of opioid analgesics on neuronal excitability?
What is the main effect of opioid analgesics on neuronal excitability?
Signup and view all the answers
What are the indications for NSAIDs?
What are the indications for NSAIDs?
Signup and view all the answers
What are the subclasses of NSAIDs?
What are the subclasses of NSAIDs?
Signup and view all the answers
How can local anesthetics be utilized?
How can local anesthetics be utilized?
Signup and view all the answers
What does the acronym NSAIDs stand for?
What does the acronym NSAIDs stand for?
Signup and view all the answers
What is the mechanism of action of local anesthetics for providing analgesia?
What is the mechanism of action of local anesthetics for providing analgesia?
Signup and view all the answers
Which subclass of NSAIDs includes drugs like aspirin?
Which subclass of NSAIDs includes drugs like aspirin?
Signup and view all the answers
Which effect is NOT associated with opioid analgesics?
Which effect is NOT associated with opioid analgesics?
Signup and view all the answers
What is the primary target of NSAIDs' inhibitory action?
What is the primary target of NSAIDs' inhibitory action?
Signup and view all the answers
Which receptor type do opioid analgesics activate to reduce neuronal excitability?
Which receptor type do opioid analgesics activate to reduce neuronal excitability?
Signup and view all the answers
Which condition is a contraindication for the use of opioid analgesics?
Which condition is a contraindication for the use of opioid analgesics?
Signup and view all the answers
What is the primary reason for the development of Grapiprant as a new analgesic?
What is the primary reason for the development of Grapiprant as a new analgesic?
Signup and view all the answers
Which effect is NOT a potential side effect of NSAIDs?
Which effect is NOT a potential side effect of NSAIDs?
Signup and view all the answers
What is the primary indication for the use of NSAIDs?
What is the primary indication for the use of NSAIDs?
Signup and view all the answers
Which opioid receptor type is associated with respiratory depression when activated?
Which opioid receptor type is associated with respiratory depression when activated?
Signup and view all the answers
Which class of drugs is most likely to have predictable differences in analgesic efficacy based on the type of receptor agonist?
Which class of drugs is most likely to have predictable differences in analgesic efficacy based on the type of receptor agonist?
Signup and view all the answers
Which opioid is considered to be more effective than buprenorphine?
Which opioid is considered to be more effective than buprenorphine?
Signup and view all the answers
Which type of NSAID is less likely to cause gastrointestinal ulceration than non-selective COX inhibitors?
Which type of NSAID is less likely to cause gastrointestinal ulceration than non-selective COX inhibitors?
Signup and view all the answers
Which opioid is included in Schedule 3 of controlled drugs?
Which opioid is included in Schedule 3 of controlled drugs?
Signup and view all the answers
Which route of administration is preferred for hospitalised patients requiring analgesics?
Which route of administration is preferred for hospitalised patients requiring analgesics?
Signup and view all the answers
Which opioid is well absorbed through feline buccal mucous membranes?
Which opioid is well absorbed through feline buccal mucous membranes?
Signup and view all the answers
Which opioid patch has a long duration of action but may have problems with adhesion and abuse potential?
Which opioid patch has a long duration of action but may have problems with adhesion and abuse potential?
Signup and view all the answers
Which NSAID is available as granules added to feed, oral pastes & suspensions, and palatable/chewable tablets?
Which NSAID is available as granules added to feed, oral pastes & suspensions, and palatable/chewable tablets?
Signup and view all the answers
Which opioid is known for its rapid onset of action and short duration when administered intravenously?
Which opioid is known for its rapid onset of action and short duration when administered intravenously?
Signup and view all the answers
Why is it important to consider the potency of opioids?
Why is it important to consider the potency of opioids?
Signup and view all the answers
Which type of drug is known to have a lower injection volume due to its potency?
Which type of drug is known to have a lower injection volume due to its potency?
Signup and view all the answers
What is the new development in analgesia acting as an antagonist of prostaglandin E2 at EP4 receptors while sparing the production of 'physiological' prostaglandins, leading to fewer adverse effects?
What is the new development in analgesia acting as an antagonist of prostaglandin E2 at EP4 receptors while sparing the production of 'physiological' prostaglandins, leading to fewer adverse effects?
Signup and view all the answers
Which class of drugs can be utilized for pain relief, sedation, reducing the required dose of general anesthetic, treating diarrhea, and controlling coughing?
Which class of drugs can be utilized for pain relief, sedation, reducing the required dose of general anesthetic, treating diarrhea, and controlling coughing?
Signup and view all the answers
What is the mechanism of action of NSAIDs?
What is the mechanism of action of NSAIDs?
Signup and view all the answers
Which opioid is known to have a rapid onset of action and short duration when administered intravenously?
Which opioid is known to have a rapid onset of action and short duration when administered intravenously?
Signup and view all the answers
What do local anesthetics block to provide analgesia and antidysrhythmic action?
What do local anesthetics block to provide analgesia and antidysrhythmic action?
Signup and view all the answers
Study Notes
Understanding Analgesia: Opioids, NSAIDs, and Local Anesthetics
- Analgesia is not just the absence of pain but also a reduction in perceived pain.
- Classes of analgesic drugs include opioids, NSAIDs, local anesthetics, alpha2-agonists, and ketamine.
- Opioid analgesics activate mu, delta, and kappa opioid receptors to reduce neuronal excitability, leading to effects such as analgesia, sedation, euphoria/dysphoria, respiratory depression, and reduced gut motility.
- Opioid analgesics are indicated for pain relief, sedation, reducing the required dose of general anesthetic, treating diarrhea, and controlling coughing.
- Contraindications for opioid analgesics include existing hypoventilation and elevated intracranial pressure.
- NSAIDs inhibit the production of prostaglandins and thromboxanes by cyclo-oxygenase enzymes, providing analgesic and anti-inflammatory effects but may lead to side effects such as dyspepsia, GIT ulceration, renal toxicity, and hepatic toxicity.
- NSAIDs are indicated for pain management, management of inflammatory disorders, antipyretic agents, management of endotoxemia, and management of pro-thrombotic states.
- Contraindications for NSAIDs include gastrointestinal tract disease, acute or chronic renal disease, impaired hepatic function, and haemostatic disorders.
- There are various subclasses of NSAIDs, including salicylic acids, para-aminophenol, pyrazolones, oxicams, and propionic acids.
- NSAIDs can be categorized according to their selectivity for COX-2, with non-selective COX inhibitors, preferential COX-2 inhibitors, and specific COX-2 inhibitors.
- Grapiprant is a new development in analgesia, acting as an antagonist of prostaglandin E2 at EP4 receptors while sparing the production of "physiological" prostaglandins, leading to fewer adverse effects.
- Local anesthetics block sodium channels, preventing the initiation and conduction of action potentials, providing analgesia and antidysrhythmic action, but may lead to CNS and CVS toxicity. They can be utilized through various techniques such as topical application, infiltration, and instillation into a cavity or wound.
Understanding Analgesia: Opioids, NSAIDs, and Local Anesthetics
- Analgesia is not just the absence of pain but also a reduction in perceived pain.
- Classes of analgesic drugs include opioids, NSAIDs, local anesthetics, alpha2-agonists, and ketamine.
- Opioid analgesics activate mu, delta, and kappa opioid receptors to reduce neuronal excitability, leading to effects such as analgesia, sedation, euphoria/dysphoria, respiratory depression, and reduced gut motility.
- Opioid analgesics are indicated for pain relief, sedation, reducing the required dose of general anesthetic, treating diarrhea, and controlling coughing.
- Contraindications for opioid analgesics include existing hypoventilation and elevated intracranial pressure.
- NSAIDs inhibit the production of prostaglandins and thromboxanes by cyclo-oxygenase enzymes, providing analgesic and anti-inflammatory effects but may lead to side effects such as dyspepsia, GIT ulceration, renal toxicity, and hepatic toxicity.
- NSAIDs are indicated for pain management, management of inflammatory disorders, antipyretic agents, management of endotoxemia, and management of pro-thrombotic states.
- Contraindications for NSAIDs include gastrointestinal tract disease, acute or chronic renal disease, impaired hepatic function, and haemostatic disorders.
- There are various subclasses of NSAIDs, including salicylic acids, para-aminophenol, pyrazolones, oxicams, and propionic acids.
- NSAIDs can be categorized according to their selectivity for COX-2, with non-selective COX inhibitors, preferential COX-2 inhibitors, and specific COX-2 inhibitors.
- Grapiprant is a new development in analgesia, acting as an antagonist of prostaglandin E2 at EP4 receptors while sparing the production of "physiological" prostaglandins, leading to fewer adverse effects.
- Local anesthetics block sodium channels, preventing the initiation and conduction of action potentials, providing analgesia and antidysrhythmic action, but may lead to CNS and CVS toxicity. They can be utilized through various techniques such as topical application, infiltration, and instillation into a cavity or wound.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your knowledge of analgesia with this quiz covering opioids, NSAIDs, and local anesthetics. Explore the mechanisms of action, indications, contraindications, and subclasses of these important classes of analgesic drugs.
